Skip to main content
SpringerLink
Log in

Animal Experimentation

  • Chapter
Principles and Practice of Research

Abstract

Animal experimentation and research with animals is an integral part of clinical research, including surgery. The goal is to solve problems encountered in clinical practice and develop new methods and approaches to the cure and alleviation of disease and disability. Animal experimentation is to be understood as research that will benefit both man and animals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. American Association of Pathologists: A workshop on needs for new animal models of human disease. Am J Pathol December 1980 (Suppl); 101(35).

    Google Scholar 

  2. Tierexperimentelle Forschung und Tierschutz/Dt. Forschungsgemeinschaft, Mitteilung III, Boldt Verlag, Boppard, 1981.

    Google Scholar 

  3. Gartner K, Hackbarth H, Stolte H. eds. Symposium on research animals and concepts of applicability to clinical medicine. Hannover FRG, 1981, Exp Biol Med Vol. 7. Basel: Karger, 1982.

    Google Scholar 

  4. Hoel DG. Animal experimentation and its relevance to man. Environ Health Perspect 1980; 32: 25–30.

    Article  Google Scholar 

  5. Hoff, C. Immoral and moral uses of animals. N Engl J Med 1980; 302: 115–18.

    Article  PubMed  CAS  Google Scholar 

  6. IABS 16th Congress for Biological Standardization, San Antonio, 1979: The standardization of animals to improve biomedical research. Basel: Production and Control S. Karger, 1980.

    Google Scholar 

  7. ILAR Symposium. The Future of Animals, Cells, Models and Systems in Research, Development, Education, and Testing. Washington, DC: National Academy of Sciences, 1977.

    Google Scholar 

  8. Kubler K, ed. Der Tierversuch in der Arzneimittelforschung (interdisziplinäres Fachgesprach im Bundesgesundheitsant) bga-Berichte 1980; 1:1–111. Dietrich Reimer Verlag, Berlin.

    Google Scholar 

  9. McDaniel CG. Animal rights or human health? Med J Aust1984; 141: 855–57.

    Google Scholar 

  10. Merkenschlager M, Wilk W. Gutachten über tierschutzgerechte Haltung von Versuchstieren. Gutachten über Tierversuche, Möglichkeiten ihrer Einschraenkung und Ersetzbarkeit. Recommendations for the keeping of laboratory animals in accordance with animal protection principles. Verlag Paul, Parey, Berlin-Hamburg: 1979.

    Google Scholar 

  11. Riecker G. Aerztliche Ethik und Tierversuche Arzt und Krankenhaus 1984; 11: 306–12.

    Google Scholar 

  12. Sechzer JA, ed. The role of animals in biomedical research. Ann NY Acad Sci 1983; 406.

    Google Scholar 

  13. Smyth HD. Alternatives to Animal Experimentation. London: Scolar Press, 1978.

    Google Scholar 

  14. Sontag KH. Der Tierversuch nach dem Stand der wissenschaftlichen Kenntnis, Pharm Ind 1982; 44: 4.

    Google Scholar 

  15. Weihe WH. Das Problem der Alternativen zum wissenschaftlichen Tierversuch. Fortschr Med 1982; 100: 2162–66.

    PubMed  CAS  Google Scholar 

  16. Ullrich KJ, Creutzfeldt OD (Ed). Gesundheit und Tierschutz. Wissenschaftler melden sich zu Wort ECON Verlag, Düsseldorf-Wien (1985).

    Google Scholar 

  17. Sedlacek H. Tierschutz: Güterabwägung oder Gleichheitsprinzip Klinikarzt 1986; 15: 508–10.

    Google Scholar 

  18. The Ethics of Animal Experimentation: Proceedings of the Second CFN Symposium Acta Physiol Scand 1986; 128 (Suppl. 554): 4–250.

    Google Scholar 

  19. Rowan AN. The concept of the three R’s, and introduction. 16th IABS Congress: the standardization of animals to improve biomedical research, production and control, San Antonio, 1979. In: Develop Biol Standard. Vol. 45, Basel: Karger, Basel: 1980; 45: 175–180.

    Google Scholar 

  20. Russell, WMS, Burch RL. The Principle of Humane Experimental Technique. London: Methuen, 1959.

    Google Scholar 

  21. Stiller H, Stiller M. Tierversuch and Tierexperimentator. F. Hirthammer Verlag, München. 1977.

    Google Scholar 

  22. Kirsch U. Untersuchungen zum Eintritt der Totenstarre an ischamischen Meerschweinchenherzen in Normothermie. Arzneim Forsch 1970; 20: 1071–74.

    CAS  Google Scholar 

  23. Carrentier S, Murawsky M, Carpentier A. Cytotoxicity of cardioplegic solutions: evaluation by tissue culture. Circulation 1981;64 (Suppl. II),II:90-II-95.

    Google Scholar 

  24. Isselhard W, Schorn B, Huegel W, Uekermann U Comparison of three methods of myocardial protection. Thorac Cardiovasc Surgeon 1980; 28: 329–126.

    Article  CAS  Google Scholar 

  25. Hügel W, Lübbing H, Isselhard W, et al. Hemodynamics and metabolic status of the human heart after application of different forms of cardioplegic solutions. In: Myocardial Protection for Cardiovascular Surgery, Isselhard W, ed. München Pharmazeutische Verlagsgesellschaft, 1981.

    Google Scholar 

  26. Rowan AN. Laboratory animals and alternatives in the 80s. Int J Study Anim Probl 1980; 1: 162–69.

    Google Scholar 

  27. Wessler S. Introduction: what is a model? In: Animal Models of Thrombosis and Hemorrhagic Diseases. Bethesda, MD: National Institutes of Health, 1976: XI-XVI.

    Google Scholar 

  28. ILAR National Research Council Committee on Animal Models for Research on Aging. Mammalian Models for Research on Aging. Washington, DC: National Academy Press, 1981.

    Google Scholar 

  29. Held JR. Appropriate animal models. In: The Role of Animals in Biomedical Research, Sechzer, JA, ed. Ann NY Acad Sci 1983; 406: 13–19.

    Google Scholar 

  30. Gill THJ. The use of randomly bred and genetically defined animals in biomedical research. Am J Pathol 1981; 100: 21–32.

    Google Scholar 

  31. Jones TC. The value of animal models. Am J Pathol 1981; 101: 3–9.

    Google Scholar 

  32. Leader RW, Padgett GA: The genesis and validation of animal models. Am J Pathol 1981; 101: 11–17.

    Google Scholar 

  33. Festing FW. Inbred Strains in Biochemical Research. London and Basingstoke: Macmillan, 1979.

    Google Scholar 

  34. Jay GE. Genetic strains and stocks. In: Durdette WJ, ed. Methodology in mammalian genetics. Holden-Day, San Francisco, 1963: 83–126.

    Google Scholar 

  35. Bustad LK, Hegreberg GA, Padgett GA. Animal models. In: The future of animals, cells, models and systems in research development, education and testing. Nat Acad of Sci, 1977.

    Google Scholar 

  36. Andrews EJ, Ward BC, Altman NH, eds. Spontaneous models of human diseases. Academic Press, 1979.

    Google Scholar 

  37. Szabo S. Animal model of human disease: duodenal ulcer disease. Animal model: cysteamine-induced acute and chronic duodenal ulcer in the rat. Amer J Pathol. 1978; 93: 273–76.

    CAS  Google Scholar 

  38. Szabo S, Haith LR Jr, Reynolds ES. Pathogenesis of duodenal ulceration produced by cysteamine or proprionitrile: influence of vagotomy, sympathectomy, histamine depletion. H2 - receptor antagonists and hormones. Am J Dig Dis 1979; 24: 471–74.

    Article  CAS  Google Scholar 

  39. Brady JV. Ulcers in “Executive” Monkeys. Sci Am 1958; 199: 99–100.

    Article  Google Scholar 

  40. Szabo S. Discussion. Am J Pathol 1980; 100: 78–82.

    Google Scholar 

  41. Cornelius CE. Animal models: a neglected medical resource. N Engl J Med 1969; 281: 933–944.

    Article  Google Scholar 

  42. McPeek B. Darstellung von Elementen des Designs und derer Analyse in klinischen Studien. In: Rohde H, Troidl H, eds. Das Margenkarzinom, Thieme Verlag, Stuttgart, 1984; 35–9.

    Google Scholar 

  43. Pollock AV. Design and interpretation of clinical trials Br Med J 1985; 290: 243.

    CAS  Google Scholar 

  44. Juhr NC. Die Optimierung des Tierversuchs — Aufgabe einer Tierversuchskunde. In: Kübler K ed. Der Tierversuch in der Arzneimittelforschung bgaBerichte. Dietrich Reimer-Verlag, Berlin, 1980; 1: 57–62.

    Google Scholar 

  45. Held JR. Mühlbock memorial lecture: consideration in the provision and characterization of animal models. In: Spiegel A, Erichsen S, Solleveld HA, eds Animal quality and models in biomedical research. Stuttgart, New York: G. Fischer Verlag, 1980; 9–16.

    Google Scholar 

  46. Immich H. Medizinische Statistik. Stuttgart, New York: Schattauer Verlag, 1974.

    Google Scholar 

  47. Dixon WJ. The up-and-down method for small samples Am. Statis. Assoc., 1965; 60: 967–978.

    Article  Google Scholar 

  48. Hsu CK, New AE, Mayo JG. Quality assurance of rodent models. 7th ICLAS Symp., Utrecht 1979 G. Fischer, Stuttgart, New York: 1980; 17–28.

    Google Scholar 

  49. Bonnod J. Principles of ethics in animal experimentation. 16th IABS Congress: the standardization of animals to improve biomedical research, production and control. San Antonio 1979, Developments in Biological Standardization. S. Karger, Basel. 1980; 45: 185–187.

    CAS  Google Scholar 

  50. Rowsell HC. The ethics of biomedical experimentation. In: the future of animals, cells, models and systems in research, development, education, and testing. Washington, D.C.: Nat Acad of Sci, 1977.

    Google Scholar 

Download references

Authors
  1. W. H. Isselhard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Kusche
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Cologne, Surgical Clinic Merheim, D-5000, Cologne 91, Federal Republic of Germany

    Hans Troidl

  2. Department of Epidemiology and Biostatistics, McGill University, H3A 1A2, Montreal, Quebec, Canada

    Walter O. Spitzer

  3. Department of Anaesthesia, Harvard University, Massachusetts General Hospital, 02114-2696, Boston, Massachusetts, USA

    Bucknam McPeek

  4. Department of Surgery, McGill University, Montreal General Hospital, H3G 1A4, Montreal, Quebec, Canada

    David S. Mulder

  5. Division of Thoracic Surgery, Toronto General Hospital, Eaton North 10-226, M5G2C4, Toronto, Ontario, Canada

    Martin F. McKneally

  6. Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, 23298-0645, Richmond, Virginia, USA

    Andrew S. Wechsler

  7. Department of General Surgery, MD Anderson Cancer Center, 77030, Houston, Texas, USA

    Charles M. Balch

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Isselhard, W.H., Kusche, J. (1991). Animal Experimentation. In: Troidl, H., et al. Principles and Practice of Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0371-8_35

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-0371-8_35

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-0373-2

  • Online ISBN: 978-1-4684-0371-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation