Hypogonadism and Osteoporosis
Hypogonadism has been a recognized major feature of Prader-Willi syndrome (PWS) since it was first described (Prader, Labhart, & Willi, 1956). It has been shown to be hypogonadotropic in origin, and is manifested initially by small or poorly developed external genitalia and later by deficiencies of pubertal development, short stature, and infertility (Table 3.1). Osteoporosis is a recently described finding in PWS that is likely to be an additional consequence of hypogonadism, at least in part. There is presently no standard approach to the management of the hypogonadism, although recent reports suggest that treatment may have beneficial results.
KeywordsShort Stature Pubertal Development Undescended Testicle Testosterone Therapy Pubertal Growth Spurt
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