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Chromosome Structural Aberrations

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Human Chromosomes

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Abstract

Chromosomes sometimes break spontaneously, or breakage may be caused by a mutagenic agent, such as ionizing radiation or a chemical compound. Unlike normal chromosome ends, broken ends tend to join each other. Usually the broken ends rejoin; in other words, the break heals. However, a break may lead to a deletion or, if more than one break has occurred in a cell, to structural rearrangements of chromosomes. At least three different DNA repair systems may be involved in the joining of broken chromosome ends (cf. Bartram, 1980).

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Authors and Affiliations

  1. Laboratory of Genetics, University of Wisconsin, 53706, Madison, WI, USA

    Eeva Therman

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  1. Eeva Therman
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© 1986 Springer-Verlag New York Inc.

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Therman, E. (1986). Chromosome Structural Aberrations. In: Human Chromosomes. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0269-8_7

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  • DOI: https://doi.org/10.1007/978-1-4684-0269-8_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96173-6

  • Online ISBN: 978-1-4684-0269-8

  • eBook Packages: Springer Book Archive

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