Abstract
Although normal mitosis is characterized by the regular alternation of chromosome reproduction and segregation of daughter chromosomes, the two processes are not necessarily correlated, and their relationship can be changed in different ways (cf. Oksala, 1954). As a rule, such modifications lead to a chromosome constitution differing from the basic complement of the individual (Fig. XII.1). Apart from multipolar mitoses, all other mitotic modifications are characterized by an absent or defective spindle, and in most cases these result in the duplication of the chromosome number (Fig. XII.2). Nagl (1978) has united the most important of these mechanisms, endoreduplication and endomitosis, under the term endocycles. The terminology referring to mitotic modifications has been the subject of considerable dispute. I shall use that proposed by Levan and Hauschka (1953), since it is established in the literature.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beerman W (1962) Riesenchromosomen. In: Protoplasmatologia, Handbuch der Protoplasmaforschung, Vol VI, D. Springer, Vienna
D’Amato F (1952) Polyploidy in the differentiation and function of tissues and cells in plants. Caryologia 4: 311–358
Geitler L (1939) Die Entstehung der polyploiden Somakerne der Heteropteren durch Chromosomenteilung ohne Kernteilung. Chromosoma 1: 1–22
Geitler L (1953) Endomitose und endomitotische Polyploidisierung. In: Protoplasmatologia, Handbuch der Protoplasmaforschung, Vol VI, C. Springer, Vienna
Heitz E (1953) Über intraindividuale Polyploidie. Arch Julius Klaus- Stiftung 28: 260–271
Kiknadze II, Istomina A G (1980) Endomitosis in grasshoppers. I. Nuclear morphology and synthesis of DNA and RNA in the endopolyploid cells of the inner parietal layer of the testicular follicle. Eur J Cell Biol 21: 122–133
Levan A, Hauschka S T (1953) Endomitotic reduplication mechanism in ascites tumors of the mouse. J Nat Cancer Inst 14: 1–46
Nagl W (1976) Nuclear organization. Annu Rev Plant Physiol 27: 39–69
Nagl W (1978) Endopolyploidy and polyteny in differentiation and evolution. Elsevier/North-Holland, Amsterdam
Nagl W (1981) Polytene chromosomes of plants. Int Rev Cytol 73: 21–53
Oksala T (1954) Timing relationships in mitosis and meiosis. Caryologia (Suppl) 6: 272–281
Oksala T, Therman E (1974) Mitotic abnormalities and cancer. In: German J (ed) Chromosomes and cancer. Wiley, New York, pp 239–263
Oksala T, Therman E (1977) Endomitosis in tapetal cells of Eremurus (Liliaceae). Am J Bot 64: 866–872
Sarto G E, Stubblefield P A, Therman E (1982) Endomitosis in human trophoblast. Hum Genet 62: 228–232
Therman E, Murashige T (1984) Polytene chromosomes in cultured pea roots (Pisum, Fabaceae). Pl Syst Evol 148: 25–33
Therman E, Sarto G E, Buchler D A (1983a) The structure and origin of giant nuclei in human cancer cells. Cancer Genet Cytogenet 9: 9–18
Therman E, Sarto G E, Kuhn E M (1985) The course of endomitosis in human cells. Cancer Genet Cytogenet (in press)
Therman E, Sarto G E, Stubblefield, P A (1983b) Endomitosis: a reappraisal. Human Genet 63: 13–18
Therman E, Timonen S (1950) Multipolar spindles in human cancer cells. Hereditas 36: 393–405
Tschermak-Woess E (1956) Karyologische Pflanzenanatomie. Protoplasma 46: 798–834
Zybina E V, Kudryavtseva M V, Kudryavtsev B N (1975) Polyploidization and endomitosis in giant cells of rabbit trophoblast. Cell Tiss Res 160: 525–537
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Therman, E. (1986). Modifications of Mitosis. In: Human Chromosomes. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0269-8_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0269-8_12
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-96173-6
Online ISBN: 978-1-4684-0269-8
eBook Packages: Springer Book Archive