Abstract
The basic theory of using genetic markers to manipulate the loci controlling a trait of interest to plant geneticists was introduced by Sax (1923) over 70 years ago. The application of this theory since that time has been limited by the lack of available segregating genetic markers. Recent advances in methods for assaying DNA polymorphisms have produced hundreds of segregating genetic markers in many species. These advances have allowed the application and further development of the theory of Sax. The genetic markers have been used: (1) as X variables in linear and nonlinear models to determine which markers are near (with reference to genetic recombination) loci controlling a trait of interest; (2) as indirect selection criteria; and (3) in traditional linkage analysis to arrange them into dense genetic linkage maps. Information from the map can be used further to map genetically the trait loci and to determine starting points for finding the trait loci using physical mapping.
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© 1996 Birkhäuser Boston
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Bridges, W.C., Sobral, B.W.S. (1996). Validation Strategies for Analysis of Quantitative Trait Loci Using Markers. In: Sobral, B.W.S. (eds) The Impact of Plant Molecular Genetics. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9855-8_2
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DOI: https://doi.org/10.1007/978-1-4615-9855-8_2
Publisher Name: Birkhäuser Boston
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