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The Contribution of the Serotonergic Innervation of the Hippocampus to the Effects of Combined Cholinergic/Serotonergic Deficits

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Neurotransmitter Interactions and Cognitive Function

Abstract

A most disturbing aspect of aging is the reduction in cognitive abilities (Bartus et al., 1982; Weingartner et al., 1987). Although acetylcholine (ACh) is suggested to have a prime role in memory processes (Bartus et al., 1982; Kesner, 1988; Lebrun et al., 1990; Toumane et al., 1988), it is now widely accepted that other neuromodulatory systems participate, probably interactively, in these processes (Baker and Reynolds, 1989; Decker and McGaugh, 1991; Rossor and Iversen, 1986; Segal, 1982) and that a reduction in the functioning of these systems may underlie some aspects of memory deficits associated with aging (Allain et al., 1989; Steinbusch et al., 1989).

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Authors
  1. Gal Richter-Levin
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  2. Menahem Segal
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, Duke University Medical Center, 27710, Durham, NC, USA

    Edward D. Levin

  2. Abbott Laboratories, Abbott Park, IL, 60064, USA

    Michael W. Decker

  3. Laboratory of Chemical Neuroanatomy, Department of Psychology, University of California, Los Angeles, CA, 90024-1563, USA

    Larry L. Butcher

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© 1992 Birkhäuser Boston

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Richter-Levin, G., Segal, M. (1992). The Contribution of the Serotonergic Innervation of the Hippocampus to the Effects of Combined Cholinergic/Serotonergic Deficits. In: Levin, E.D., Decker, M.W., Butcher, L.L. (eds) Neurotransmitter Interactions and Cognitive Function. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9843-5_14

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  • DOI: https://doi.org/10.1007/978-1-4615-9843-5_14

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9845-9

  • Online ISBN: 978-1-4615-9843-5

  • eBook Packages: Springer Book Archive

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