Abstract
An increased understanding of receptor mediated processes of species specific pathogens can be obtained by creating novel animal models which possess distinctive features that differ fundamentally from those biological properties displayed naturally by the unaltered animal species. For example, the pathogenesis of certain infectious diseases of importance to human and veterinary medicine is initiated by the binding of the etiological agents directly to host or tissue specific microbial receptors located on cell surfaces. Therefore, biologically relevant animal models for these particular infectious diseases could theoretically be established by transferring cells that contain the appropriate microbial attachment receptors to selected tissues of common laboratory animals. The histologically modified animals should now become susceptible to infection by those host and tissue restricted microbial pathogens to which the unaltered animals are naturally resistant.
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© 1992 Birkhäuser Boston
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Heller, R., Gilbert, R. (1992). Model System for the Study of Gonorrhea Created by Cell-Tissue Electrofusion. In: Allen, M.J., Cleary, S.F., Sowers, A.E., Shillady, D.D. (eds) Charge and Field Effects in Biosystems—3. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9837-4_33
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DOI: https://doi.org/10.1007/978-1-4615-9837-4_33
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