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The Possible Role of Aspartame in Seizure Induction

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Dietary Phenylalanine and Brain Function

Abstract

Although aspartame is widely used, and generally considered safe, there is evidence that it has an effect on monoamine metabolism which could theoretically lower seizure threshold. Eight cases are presented in whom it would appear likely that seizures were induced by ingestion of this artificial sweetener. Clinicians are urged to take into account the possible role of aspartame when evaluating patients with seizures, or with disorders in which alterations in catecholamine and indolea-mine metabolism have been implicated.

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References

  • Blundell, J.E., and Hill, A.J. (1986). Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet i: 1092–1093.

    Article  Google Scholar 

  • Bradstock, M.K., Serdula, M.K., Marks, J.S., Barnard, R.J., Crane, N.T., Remington, P.L., and Trowbridge, F. (1986). Evaluation of reactions to food additives: the aspartame experience. Am. J. Clin. Nutr. 43:464–469.

    PubMed  CAS  Google Scholar 

  • Council on Scientific Affairs (1985). Aspartame: review of safety issues. J. Am. Med. Assoc. 254:400–402.

    Article  Google Scholar 

  • Drake, M.E. (1986). Panic attacks and excessive aspartame ingestion. Lancet ii:631.

    Article  Google Scholar 

  • Horwitz, D.L., and Bauer-Nehrling, J.K. (1983). Can aspartame meet our expectations? J. Am. Diet Assoc. 83:142–146.

    PubMed  CAS  Google Scholar 

  • Walton, R.G. (1986). Seizure and mania after high intake of aspartame. Psycho-somatics 27:218–220.

    CAS  Google Scholar 

  • Wurtman, R.J. (1983). Neurochemical changes following high-dose aspartame with dietary carbohydrates. N. Engl. J. Med. 309:429–430.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman, R.J. (1985): Aspartame: possible effects on seizure susceptibility. Lancet ii: 1060.

    Article  Google Scholar 

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© 1988 Birkhäuser Boston

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Walton, R.G. (1988). The Possible Role of Aspartame in Seizure Induction. In: Wurtman, R.J., Ritter-Walker, E. (eds) Dietary Phenylalanine and Brain Function. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9821-3_18

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  • DOI: https://doi.org/10.1007/978-1-4615-9821-3_18

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9823-7

  • Online ISBN: 978-1-4615-9821-3

  • eBook Packages: Springer Book Archive

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