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Surfactant Lipids and Proteins in the Perinatal and Adult Lung

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Book cover Endocrine and Biochemical Development of the Fetus and Neonate

Part of the book series: Reproductive Biology ((RBIO))

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Abstract

The alveolar surfaces of the lungs are coated with a highly surface-active material. This material, pulmonary surfactant, consists for approx. 90% of lipids and contains, in addition, several specific proteins (1). Pulmonary surfactant is manufactured in the type II pneumocytes (2), one of the epithelial cell types in the alveolar walls. The type II pneumocytes secrete the surfactant into the fluid layer that covers the alveolar epithelium. The surfactant lipids can subsequently spread as a monolayer at the air-liquid interface and, by decreasing surface tension, protect the alveoli against collapse at end-expiration. By reducing the contractile force in the curved air-liquid interface, pulmonary surfactant also precludes alveolar edema (3). Although the major physiologic function of pulmonary surfactant is undoubtedly to confer mechanical stability to the alveoli, there are important suggestions that the surfactant system also plays a role in several pulmonary defense mechanisms (for review see ref.4).

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Authors and Affiliations

  1. Laboratory of Veterinary Biochemistry, Spain

    Henk P. Haagsman, Joseph J. Batenburg, Cecile Clercx, Math J. H. Geelen & Lambert M. G. van Golde

  2. Small Animal Clinic, University of Utrecht, Utrecht, The Netherlands

    Cecile Clercx

Authors
  1. Henk P. Haagsman
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  2. Joseph J. Batenburg
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  3. Cecile Clercx
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  4. Math J. H. Geelen
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  5. Lambert M. G. van Golde
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Editors and Affiliations

  1. Universidad Autonoma de Madrid, Madrid, Spain

    José M. Cuezva

  2. C.S.I.C. Universidad Complutense de Madrid, Madrid, Spain

    Ana M. Pascual-Leone

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Mulchand S. Patel

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Haagsman, H.P., Batenburg, J.J., Clercx, C., Geelen, M.J.H., van Golde, L.M.G. (1990). Surfactant Lipids and Proteins in the Perinatal and Adult Lung. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_24

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