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Development and Molecular Biology of Mammalian Pyruvate Dehydrogenase Complex

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Endocrine and Biochemical Development of the Fetus and Neonate

Part of the book series: Reproductive Biology ((RBIO))

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Abstract

Glucose is the major fuel for oxidative metabolism in the developing fetus. A continuous supply of glucose and other nutrients from the maternal circulation to the fetus via the placenta is essential for normal fetal development. The initial metabolism of glucose to pyruvate occurs by the glycolytic pathway; further oxidation of pyruvate to C02 takes place through the tricarboxylic acid cycle in mitochondria. These two pathways are functionally linked by the pyruvate dehydrogenase complex (PDC) in the mitochondria. The level of oxidative metabolism of pyruvate continually increases in different tissues beginning in the early postnatal period, and gradually reaches the maximal levels observed in tissues from adults. In this chapter, we will discuss the structure, function and regulation of mammalian PDC with special emphasis on recent advances in the cloning of several components of the complex. Additionally, the expression of PDC activity in differentiating cultured cells and developing animals will be discussed. The importance of normal pyruvate oxidation during early mammalian development will be underlined by discussing the effects of inborn errors of PDC.

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Authors and Affiliations

  1. Departments of Biochemistry and Nutrition and Pew Center for Molecular Nutrition Case, Western Reserve University School of Medicine Cleveland, Ohio, 44106, USA

    Mulchand S. Patel, Lap Ho & Donna J. Carothers

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  1. Mulchand S. Patel
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  2. Lap Ho
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  3. Donna J. Carothers
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Editors and Affiliations

  1. Universidad Autonoma de Madrid, Madrid, Spain

    José M. Cuezva

  2. C.S.I.C. Universidad Complutense de Madrid, Madrid, Spain

    Ana M. Pascual-Leone

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Mulchand S. Patel

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Patel, M.S., Ho, L., Carothers, D.J. (1990). Development and Molecular Biology of Mammalian Pyruvate Dehydrogenase Complex. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_18

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  • DOI: https://doi.org/10.1007/978-1-4615-9567-0_18

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