Skip to main content

Inhibitory Effects of Chlorogenic Acid, Reserpine, Polyprenoic Acid (E-5166), or Coffee on Hepatocarcinogenesis in Rats and Hamsters

  • Chapter
Antimutagenesis and Anticarcinogenesis Mechanisms II

Abstract

Four different experiments were performed in order to examine the modifying effects of chlorogenic acid (CA), reserpine, polyprenoic acid (E-5166), and coffee on chemical carcinogenesis in rats or hamsters. Experiment 1: The numbers of hyperplastic liver cell foci and the incidence of colon tumors in male and female Syrian golden hamsters given a single intraveneous injection of methylazoxymethanol (MAM) acetate and then fed the diet containing 0.025% CA for 24 wk were significantly lower than those of hamsters given MAM acetate alone. Experiment 2: The incidence of altered hepatocellular foci in female ACI/N rats given N-2-fluorenylacetamide (FAA, 0.02% in diet) for 10 wk and reserpine (weekly subcutaneous injections, 1 μg/g body weight) during or after (17 wk) FAA exposure was significantly lower than that of rats given FAA alone. Experiment 3: The number of hepatocellular foci in male ACI/N rats given 0.02% FAA diet for 13 wk and E-5166 by gavage (40 mg/kg body weight, 3 times/wk) for 16 wk after the end of FAA exposure was significantly smaller than that in rats given FAA diet alone. Experiment 4: Incidences of liver tumors and hepatocellular foci of rats given concurrent dietary administration of aminopyrine (0.01%) and sodium nitrite (0.1%) and coffee solution as a drinking water for 630 da were significantly lower than those of rats given aminopyrine and sodium nitrite. Thus, the tested compounds had inhibitory effects on chemical carcinogenesis in liver or colon.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Birnbaum, L., T. Sapp, and J. Moore (1976) Effects of reserpine, epidermal growth factor, and cyclic nucleotide modulator on epidermal mitosis. J. Invest. Dermatol. 66:313–318.

    Article  PubMed  CAS  Google Scholar 

  2. Bollag, W. (1974) Therapeutic effect of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur. J. Cancer 10:731–737.

    PubMed  CAS  Google Scholar 

  3. Challis, B.C., and C.D. Bartlett (1975) Possible cocarcinogenic effects of coffee constituents. Nature 254:532–533.

    Article  PubMed  CAS  Google Scholar 

  4. Das, M., D.R. Bickers, and H. Mukhtar (1984) Plant phenols as in vitro inhibition of glutathione S-transferase(s). Biochem. Biophys. Res. Commun. 127:427–433.

    Article  Google Scholar 

  5. Emminger, A., and U. Mohr (1982) Tumours of the oral cavity, cheek pouch, salivary glands, oesophagus, stomach and intestines. In Pathology of Tumours in Laboratory Animals. Vol. III: Tumours of the Hamster, V.S. Turusov, ed. IARC, Lyon, pp. 45–68.

    Google Scholar 

  6. Hayase, F., and H. Kato (1984) Antioxidative compounds of sweet potatoes. J. Nutri. Sci. Vitaminol. 30:37–46.

    Article  CAS  Google Scholar 

  7. Heinonen, O.P., S. Shapiro, L. Touminen, and M.I. Turunen (1974) Reserpine use in relation to breast cancer. Lancet 2:675–677.

    Article  PubMed  CAS  Google Scholar 

  8. Lam, L.K.T., V.L. Sparnins, and L.W. Wattenberg (1982) Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activitj’^ in the mouse. Cancer Res. 42:1193–1198.

    PubMed  CAS  Google Scholar 

  9. Lasca, P. (1983) Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced neoplasia in mice. Carcinogenesis 4:1651–1653.

    Article  Google Scholar 

  10. Lewis, P.D., A.J. Patel, G. Bendek, and R. Balasz (1977) Effect of reserpine on cell proliferation in the developing rat brain: A quantitative histological study. Brain Res. 129:1229–1308.

    Article  Google Scholar 

  11. Login, I.S., A.M. Judd, M.J. Cronin, T. Yamamoto, and R.M. Macleod (1985) Reserpine is a calcium channel antagonist in normal and GH3 rat pituitary cells. Am. J. Physiol. 252:E15–19.

    Google Scholar 

  12. Lupulescu, A. (1984) Reserpine and carcinogenesis: Inhibition of carcinoma formation in mice. J. Natl. Cancer Inst. 71:57–62.

    Google Scholar 

  13. Mori, H., and I. Hirono (1977) Effect of coffee on carcinogenicity of cycasin. Br. J. Cancer 35:369–371.

    Article  PubMed  CAS  Google Scholar 

  14. Muto, Y., and H. Moriwaki (1984) Antitumor activity of vitamin A and its derivatives. J. Natl. Cancer Inst. 73:1389–1393.

    PubMed  CAS  Google Scholar 

  15. Muto, Y., H. Moriwaki, and M. Omori (1981) In vitro binding affinity of novel synthetic polyprenoid (polyprenoic acids) to cellular retinoid-binding proteins. Gann 72:974–977.

    PubMed  CAS  Google Scholar 

  16. Ross, R.K., A. Paganini-Hill, M.D. Krilo, V.R. Gerkins, B.E. Henderson, and M.C. Pike (1984) Effects of reserpine on prolactin levels and incidence of breast cancer in postmenopausal women. Cancer Res. 44:3106–3108.

    PubMed  CAS  Google Scholar 

  17. Schroder, E.W., and P.H. Black (1980) Retinoids: Tumor preventers or tumor enhancers? J. Natl. Cancer Inst. 65:671–674.

    PubMed  CAS  Google Scholar 

  18. Snowdon, D.A., and R.L. Phillips (1984) Coffee consumption and risk of fatal cancers. Am. J. Publ. Health 74:820–823.

    Article  CAS  Google Scholar 

  19. Sondenheimer, E. (1964) Chlorogenic acids and related depsides. Bot. Rev. 30:677–712.

    Google Scholar 

  20. Sporn, M.B., and D.L. Newton (1979) Chemoprevention of cancer with retinoids. Fed. Proc. 38:2528–2534.

    PubMed  CAS  Google Scholar 

  21. Stewart, H.L., G.M. Williams, C.H. Keysser, L.S. Lombard, and R.J. Montali (1980) Histologie typing of liver tumors of the rat. J. Natl. Cancer Inst. 64:177–206.

    Google Scholar 

  22. Stich, H.F., M.P. Rosin, C.H. Wu, and W.D. Powrie (1981) A comparative genotoxicity study of chlorogenic acid (3-O-caffeloquinic acid). Mutat. Res. 90:201–212.

    Article  PubMed  CAS  Google Scholar 

  23. Stizel, R.E. (1977) The biological fate of reserpine. Pharmacol. Rev. 28:179–205.

    Google Scholar 

  24. Ward, J.M. (1982) Background data and variations in tumor rates of control in rats and mice. Prog. Exp. Tumor Res. 26:241–258.

    Google Scholar 

  25. Wattenberg, L. (1981) Inhibition of chemical carcinogenesis. In Cancer: Achievements, Challenges, and Prospects for the 1980’s, J.H. Burchenal, ed. Grune and Stratton, New York, pp. 517–539.

    Google Scholar 

  26. Wattenberg, L.W. (1985) Chemoprevention of cancer. Cancer Res. 45:1–8.

    Article  PubMed  CAS  Google Scholar 

  27. Welch, C.W., and J. Meites (1970) Effects of reserpine on development of 7,12-dimethylbenzanthracene-induced mammary tumors in female rats. Experientia 26:1133–1134.

    Article  Google Scholar 

  28. Wu, J.M. (1982) The influence of reserpine on nitrogen metabolizing enzymes in chick liver. Biochim. Biophys. Acta 715:57–62.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Tanaka, T. et al. (1990). Inhibitory Effects of Chlorogenic Acid, Reserpine, Polyprenoic Acid (E-5166), or Coffee on Hepatocarcinogenesis in Rats and Hamsters. In: Kuroda, Y., Shankel, D.M., Waters, M.D. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms II. Basic Life Sciences, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9561-8_45

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9561-8_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9563-2

  • Online ISBN: 978-1-4615-9561-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics