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Apolipoprotein AI-Milano: Mechanisms for the Antiatherogenic Potential

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Human Apolipoprotein Mutants 2

Abstract

The apolipoprotein AI-Milano (AI-M) has been the first described molecular variant of human apolipoproteins (1,2). It is characterized by a cysteine for arginine substitution at the position 173 in the primary sequence of apo AI (3), leading to the formation of disulphide bonded homodimers AI-M/AI-M and heterodimers with apolipoprotein AII (AI-M/AII) (2).

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© 1989 Plenum Press, New York

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Franceschini, G., Calabresi, L., Baio, M., Nichols, A.V., Sirtori, C.R. (1989). Apolipoprotein AI-Milano: Mechanisms for the Antiatherogenic Potential. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_6

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  • DOI: https://doi.org/10.1007/978-1-4615-9549-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9551-9

  • Online ISBN: 978-1-4615-9549-6

  • eBook Packages: Springer Book Archive

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