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Normolipidemic Dyslipoproteinemia in Patients with Coronary Artery Disease

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Book cover Human Apolipoprotein Mutants 2

Abstract

Evidence has been accumulated in the past years that there is a significant relationship between the concentration of circulating plasma cholesterol and the development of atherosclerosis. The results of three large prospective studies namely, the Framingham Heart Study (1), the Pooling Project (2), and the Multiple Risk Factor Intervention Trial (3), show that the relationship between plasma cholesterol and Coronary Artery Disease (CAD) is continuous and the risk of premature atherosclerosis rise dramatically with plasma cholesterol concentration above 250 mg/dl. Furthermore the recently concluded Lipid Research Clinic Primary Intervention Trial (4), The Helsinki Heart Study (5) and the Cholesterol-Lowering Atherosclerosis Study (6), all show benefit in terms of mortality by myocardial infarction resulting from reduction with hypolipidemic agents of the plasma concentration of cholesterol.

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Author information

Authors and Affiliations

  1. Department of Medicine and The Veteran Administration Hospital, Baylor College of Medicine and The Methodist Hospital, Houston, TX, USA

    Giancarlo Ghiselli, Ellison Wittels, Jacques Heibig & Antonio M. Gotto Jr.

Authors
  1. Giancarlo Ghiselli
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  2. Ellison Wittels
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  3. Jacques Heibig
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  4. Antonio M. Gotto Jr.
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Editor information

Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    C. R. Sirtori  & G. Franceschini  & 

  2. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

    H. B. Brewer Jr.

  3. University of Münster, Münster, Federal Republic of Germany

    G. Assmann

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© 1989 Plenum Press, New York

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Ghiselli, G., Wittels, E., Heibig, J., Gotto, A.M. (1989). Normolipidemic Dyslipoproteinemia in Patients with Coronary Artery Disease. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_24

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  • DOI: https://doi.org/10.1007/978-1-4615-9549-6_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9551-9

  • Online ISBN: 978-1-4615-9549-6

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