The Pathophysiological Role of Kinin and Chemical Mediators on Experimental Allergic Rhinitis
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Summary
In order to clarify the pathophysiological role of the chemical mediators, the releases of kinins, histamine and leukotriene C4(LTC4) into the nasal cavity were measured following nasal allergic challenge in ovalbumin(0A)-sensitized guinea pigs, or following nasal stimulation with one of these chemical mediators in OA-non-sensitized animals. In sensitized animals, an increased vascular permeability of nasal mucosa was recognized immediately after antigenic stimulation and lasted for 60-90 minutes. Releases of kinins and LTC4 into the nasal lavage fluid augmented not only immediately after the antigenic challenge, but also during 60 to 90 minutes after the stimulation. Release of histamine into the nasal lavage fluid was observed only immediately after the antigenic stimulat-tion. In non-sensitized guinea pigs, nasal stimulation with bradykinin accelerated nasal vascular permeability. Nasal stimulation with histamine or LTC4 resulted in increase of nasal vascular permeability and of kinins concentration in the nasal lavage fluid.
These results suggest that kinins might be concerned with the immediate and later vascular permeability during the allergic response.
Keywords
Allergic Rhinitis Vascular Permeability Allergic Response Antigenic Stimulation Pathophysiological RolePreview
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References
- 1.J.T. O’Flaherty, and R.L. Wykle, Mediators of anaphylaxis, Clin Lab. Med., 3: 619–643 (1983)PubMedGoogle Scholar
- 2.P.S. Creticos, S.P. Peters, N.F. Adkinson, R.M. Naclerio, E.C. Hayes, P.S. Norman and L.M. Lichtenstein, Peptide leukotriene release after antigen challenge in patients sensitive to ragweed, New.Engl.J.Med., 310: 1626–1630 (1984)PubMedCrossRefGoogle Scholar
- 3.R.M. Naclerio, D. Proud, A.G. Togias, N.F. Adkinson, D.A. Meyers, A. Kagey-Sobotka, M. Plaut, P.S. Norman, and L.M. Lichtenstein, Inflammatory mediators in late antigen-induced rhinitis, New Engl. J. Med.,313: 65–69 (1985)PubMedCrossRefGoogle Scholar
- 4.M. Kojima, N. Tsutsumi, M. Abe, H. Komatsu, A. Ujiie, J. Naito, and M. Nakazawa, Experimental allergic rhinitis in rats and the influence of tranilast and antihistaminics on it, JapaneseJ.Allergology.,35: 180–187 (1986)Google Scholar
- 5.K. Shimamoto, T. Ando, S. Tanaka, and O. Iimura, The determination of kinin and glandular kallikrein in human biological fluids, Allergologie (In Press)Google Scholar
- 6.H. Ishida, K. Shimamoto, T. Nishitani, S. Hosoda, T. Yokoyama, Y. Nakahashi, T. Ando, S. Tanaka, and O. Iimura, Interrelation between the renin-angiotenshin system and kallikrein kinin system in patients with essential hypertension, KININ V.,:329–336, Plenum PressGoogle Scholar
- 7.A. Ueno, K. Tanaka, M. Kotori, M. Hayashi, and Y. Arai, Species difference in increased vascular permeability by synthetic leukotriene C4 and D4, Prostaglandins., 21: 637–648 (1981)PubMedCrossRefGoogle Scholar
- 8.D. Proud, A. Togias, R.M. Naclerio, S.A. Crush, P.S. Norman, and L.M. Lichtenstein, Kinins are generated in vivo following nasal airway challenge of allergic individuals with allergen, JClin.Invest.,72: 1678–1685 (1985)CrossRefGoogle Scholar
- 9.C.R. Baumgarten, A.G. Togias, R.M. Naclerio, L.M. Lichtenstein, P.S. Norman, and D. Proud, Influx of kininogens into nasal secretions after antigen challenge of allergic individuals, JClin.Invest.,76: 191–197 (1985)CrossRefGoogle Scholar
- 10.C.R. Baumgarten, R.C. Nichols, R.M. Naclerio, L.M. Lichtenstein, P.S. Norman, and D. Proud, Plasma kallikrein during experimentally induced allergic rhinitis:role in kinin formation and contribution to TAME-esterase activity in nasal secretions, J. Immunol.,137: 977–982 (1986)PubMedGoogle Scholar
- 11.C.R. Baumgarten, R.C. Nichols, R.M. Naclerio, and D. Proud, Concentrations of glandular kallikrein in human nasal secretions increase during experimentally induced allergic rhinitis, J. Immunol.,137: 1323–1328 (1986)PubMedGoogle Scholar
- 12.H.H. Newball, R.W. Berninger, R.C. Talamo, and L.M. Lichtenstein, Anaphylactic release of a basophil kallikrein-like activity, J. Clin.Invest., 64: 457–465 (1979)PubMedCrossRefGoogle Scholar