Summary
Infusion of saline in healthy volunteers produced a significant rise in plasma atrial natriuretic peptide, which was accompanied by the urinary excretion of cyclic GMP and sodium. Although the time-course of cyclic GMP excretion almost mirrored that of plasma ANP, that of sodium showed sustained phase, indicating involvement of additional humoral regulators. ANP did not stimulate the excretion of enzymic or immunoreactive tissue kallikrein.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.J. de Bold, Tissue fractionation studies on the relationship between an atrial natriuretic factor and specific granules, Can J. Physiol. Pharmacol. 60: 324 (1982).
N.D. Millar, A.C. Williams, J.P. O’Hare, J.V. Anderson, K.D. Bhoola, S.R. Bloom and R.J.M. Corrall, Urinary cyclic nucleotides and atrial atriuretic peptide during water immersion, J. Endocr. 108: 156 Supplement (1986).
J.V. Anderson, N.D. Millar, J.P. O’Hare, J.C. Mackenzie, R.J.M. Corrall and S.R. Bloom, Atrial natriuretic peptide: physiological release associated with natriuresis during water immersion in man, Clin Sci. 71: 319 (1986).
J.V. Anderson, N.D. Millar, I. Birch, J.C. Mackenzie, S.R. Bloom and K.D. Bhoola, Relationship between circulating atrial natriuretic peptide and the urinary excretion of tissue kallikrein during water immersion, in: “Renal Function, Hypertension and Kallikrein-Kinin System”, H.S. Margolius and O. Iimura, ed., Tokyo University Press, In Press.
D.R. Singer, A.C. Shore, N.D. Markandu, M.G. Buckley, G.A. Sagnella and G.A. MacGregor, Dissociation between plasma atrial natriuretic peptide levels and urinary sodium excretion after intravenous saline infusion in normal man, Clin Sci. 73: 285 (1987).
R. Gerzer, J. Tremblay, S.C. Pang, P. Vinay, A. Delean and P. Hamet, Atrial natriuretic factor activates mammalina particulate guanylate cyclase, Fed Proc. 44: 698 (1985).
T. Kuno, J.W. Andresen, Y. Kamisuki, S.A. Waldman, L.Y. Chang, S. Saheki, D.C. Leitman, M. Nakane and F. Murad, Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung, J. Biol. Chem. 261: 5817 (1986).
A.A. Brownlee, G. Lee, I.H. Mills, F. Spinelli and Y. Wakabayashi, Stimulation of kallikrein excretion by infusion of atrial natriuretic I peptide (ANP) in rats: correlation with urine flow, sodium and I potassium excretion, J. Physiol. 377: 52P (1986).
M.R. Wilkins, J.A. Wood, D. Adu, C.J. Lote, M.J. Kendall and J. Michael, Change in plasma immunoreactive atrial natriuretic peptide during sequential ultrafiltration and haemodialysis, Clin Sci. 71: 157 (1986).
Namir Làuar, Mary Shacklady and K.D. Bhoola, Factors influencing the in vitro release of renal kallikrein, In: Recent Progress on Kinins, H. Fritz, G. Dietze, F. Fiedler and G.L. Haberland, eds., Birkhäuser, Agents nd Actions Suppl. 9: 545 (1982).
C.P. Vio and C.D. Figueroa, Evidence for a stimulatory effect of high potassium diet on renal kallikrein, Kidneynt. 31: 1327 (1987).
C.P. Vio, C.D. Figueroa and I. Coarsi, Immunocytochemical localization of kallikrein in human kidney. Relation to components of juxtaglomerular apparatus, Histochemistry (In Press).
C.D. Figueroa, A.G. Maclver, J.C Mackenzie and K.D. Bhoola, Relationship between the immunocytochemical localization of low molecular weight kininogen and tissue kallikrein in the human kidney, in: “Renal Function, Hypertension and Kallikrein-Kinin System”, H.S. Margolius and O. Iimura, eds., University of Tokyo Press, (In Press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Selwyn, B., Yelland, U., Bhoola, K.D., Lewis, H., Wilkins, M., Griffith, M. (1989). Relationship Between anp, Cyclic GMP and Tissue Kallikrein Following Saline Infusion in Healthy Volunteers. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_41
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9543-4_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9545-8
Online ISBN: 978-1-4615-9543-4
eBook Packages: Springer Book Archive