Abstract
Which genes are of interest in the study of inherited factors that predispose an individual to develop hyperlipidaemia? Table I shows a list of candidate genes that are known to be involved in the metabolism of cholesterol and triglycerides. Even though the list is not comprehensive, there is clearly a problem of how to decide which genes to study first. Some of the candidates, such as the LDL receptor, are already clearly implicated and warrant a detailed study, which would involve the isolation of the gene from patients for sequencing, and the identification of the defect at the DNA level.
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Humphries, S.E., Talmud, P.J., Williamson, R. (1986). DNA Polymorphisms and Analysis of Hyperlipidaemia. In: Sirtori, C.R., Nichols, A.V., Franceschini, G. (eds) Human Apolipoprotein Mutants. NATO ASI Series, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9474-1_2
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