Abstract
There is a considerable degree of allelic variation in human populations. Some variants have deleterious consequences for the individual possessing them, and selective forces strongly oppose their spread in populations. Other genetic variants may have been of selective advantage in the past and consequently their frequencies have increased in the population. However, due to possible changes in environment, these variants may now be neutral or slightly disadvantageous for the individual. Such variants may provide the genetic basis for the common metabolic diseases such as type II diabetes mellitus and the hyperlipidaemias. They would be expected to occur at the same frequency as the disease (at frequencies greater than 1–2% in the population) and would therefore fall within the definition of a genetic polymorphism.1
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© 1986 Springer Science+Business Media New York
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Ferns, G.A.A., Shelley, S.C., Rees, A., Stocks, J., Galton, D.J. (1986). An Apoprotein AII Gene Polymorphism and Hyperlipidaemia. In: Sirtori, C.R., Nichols, A.V., Franceschini, G. (eds) Human Apolipoprotein Mutants. NATO ASI Series, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9474-1_16
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DOI: https://doi.org/10.1007/978-1-4615-9474-1_16
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