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Local Modulation of Noradrenergic Neurotransmission in Blood Vessels of Normotensive and Hypertensive Animals

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Book cover Central and Peripheral Mechanisms of Cardiovascular Regulation

Part of the book series: NATO ASI Series ((NSSA,volume 109))

Abstract

Our concepts of adrenoceptors and their anatomical location has progressively changed since the initial classification by Ahlquist (1948) (see Table 1). Since that time evidence has been provided for the concept of subtypes of and ß1- and ß2 -adrenoceptorss Lands et al. (1967a,b); the discovery of presynaptic α - and ß-adrenoceptors, Farnebo and Hamberger (1971); Kirpekar and Puig (1971); Langer et al. (1971); Starke (1971); Adler-Graschinsky and Langer (1975); Westfall et al. (1979), with the presynaptic α-adrenoceptor given the designation of α2 and the postsynaptic adrenoceptor α1, Langer (1974), the discovery of postsynaptic α2-adrenoceptors, Drew and Whiting (1979); Docherty et al. (1979) and Langer and Hicks (1984) and finally evidence for presynaptic α1-adrenoceptors, Docherty (1984).

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Authors and Affiliations

  1. Department of Pharmacology, St. Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO, 63104, USA

    Thomas C. Westfall, Shi-Qing Zhang, Suzanne Carpentier, Linda Naes & Michael J. Meldrum

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  2. Shi-Qing Zhang
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  1. Wadsworth Center for Laboratories and Research, Albany, New York, USA

    A. Magro

  2. University of Porto, Porto, Portugal

    W. Osswald

  3. Cornell University Medical College, New York, New York, USA

    D. Reis

  4. Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    P. Vanhoutte

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Westfall, T.C., Zhang, SQ., Carpentier, S., Naes, L., Meldrum, M.J. (1986). Local Modulation of Noradrenergic Neurotransmission in Blood Vessels of Normotensive and Hypertensive Animals. In: Magro, A., Osswald, W., Reis, D., Vanhoutte, P. (eds) Central and Peripheral Mechanisms of Cardiovascular Regulation. NATO ASI Series, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9471-0_5

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