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DNA-to-Protein Crosslinks and Backbone Breaks caused by Far- and Near-Ultraviolet, and Visible Light Radiations in Mammalian Cells

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Mechanisms of DNA Damage and Repair

Part of the book series: Basic Life Sciences ((BLSC,volume 189))

Abstract

The cytotoxic, mutagenic and carcinogenic potential of germicidal far-UV* radiation has been known for decades. This radiation is not a major component of the solar radiations that reach the surface of the earth, unlike the abundant near-UV and visible radiations present in the solar spectrum. Although it has been recognized for decades that the mixture of mid-UV, near-UV, and visible radiation (wavelengths longer than 290 nm) that comprise sunlight is cytotoxic, mutagenic, and carcinogenic,1 surprisingly little attention has been paid to the specific DNA damages that may be caused in cells by these particular wavelengths of nonionizing radiation—even though these radiations are environmentally abundant, penetrate deeply through skin, and are increasingly used for cosmetic purposes (natural and artificial solar exposure of human skin).

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Author information

Authors and Affiliations

  1. Photobiology Group, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, 60439, USA

    Meyrick J. Peak & Jennifer G. Peak

Authors
  1. Meyrick J. Peak
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  2. Jennifer G. Peak
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. Chemistry Department, American University, Washington, D.C., USA

    Michael G. Simic

  3. Johns Hopkins University, Baltimore, Maryland, USA

    Lawrence Grossman

  4. New York University Medical Center, New York, New York, USA

    Arthur C. Upton

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© 1986 Plenum Press, New York

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Peak, M.J., Peak, J.G. (1986). DNA-to-Protein Crosslinks and Backbone Breaks caused by Far- and Near-Ultraviolet, and Visible Light Radiations in Mammalian Cells. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_20

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  • DOI: https://doi.org/10.1007/978-1-4615-9462-8_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9464-2

  • Online ISBN: 978-1-4615-9462-8

  • eBook Packages: Springer Book Archive

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