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Mechanisms of DNA Damage and Repair pp 119–125Cite as

DNA Modification by Sulfur Mustards and Nitrosoureas and Repair of these Lesions

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Part of the book series: Basic Life Sciences ((BLSC,volume 189))

Abstract

In this chapter, the nature and significance of DNA modifications caused by a particular mutagenic agent, chloroethyl ethyl sulfide (CEES), will be compared with those produced by a therapeutic agent, chloroethyl cyclohexyl nitrosourea (CCNU). This comparison illustrates the differences in the kind of biological response which can arise from DNA modification by different agents and the role of DNA repair in determining this response. In particular, the ability of tumor cells to become resistant to therapeutic agents has some important implications for the ability of cells in general to tolerate environmental mutagens.

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Author information

Authors and Affiliations

  1. Division of Oncology, Department of Medicine, Albany Medical College, Albany, NY, 12208, USA

    David B. Ludlum

  2. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 21010, USA

    Bruno Papirmeister

Authors
  1. David B. Ludlum
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  2. Bruno Papirmeister
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. Chemistry Department, American University, Washington, D.C., USA

    Michael G. Simic

  3. Johns Hopkins University, Baltimore, Maryland, USA

    Lawrence Grossman

  4. New York University Medical Center, New York, New York, USA

    Arthur C. Upton

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© 1986 Plenum Press, New York

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Ludlum, D.B., Papirmeister, B. (1986). DNA Modification by Sulfur Mustards and Nitrosoureas and Repair of these Lesions. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_12

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  • DOI: https://doi.org/10.1007/978-1-4615-9462-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9464-2

  • Online ISBN: 978-1-4615-9462-8

  • eBook Packages: Springer Book Archive

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