Abstract
In experimental studies with animals, cancer generally results only after multiple treatments with carcinogenic chemicals or radiation over an extended period of time. Analysis of such data has led to the conclusion that cancer results from a multi-stepped process (Peto, 1977). Similar conclusions have been arrived at in regard to human cancer, using epidemiological approaches (Peto, 1977). It should be noted, however, that there are a number of well-studied model tumor systems in which only a single high dose of the carcinogenic agent induces tumors in a majority of the animals. Examples of these include induction of rat mammary tumors by ethylnitrosourea (Stoica et al., 1984) and induction of rat brain tumors by this agent (Druckrey et al., 1966). Such experiments seem to indicate that carcinogenesis is not multi-stepped. However, they may actually represent a cryptic multi-stepped process in which the carcinogen causes the cells to advance only a single step through the transformation sequence and other steps occur spontaneously.
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McCormick, J.J., Maher, V.M. (1985). In Vitro Malignant Transformation — A Multi-Stepped Process. In: Castellani, A. (eds) Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents. NATO ASI Series, vol 96. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9445-1_10
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DOI: https://doi.org/10.1007/978-1-4615-9445-1_10
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