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Characterisation of ADP Receptors

  • Chapter
Mechanisms of Stimulus—Response Coupling in Platelets

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 192))

Abstract

Adenosine 5′-diphosphate (ADP) stimulates platelets to change shape, to develop an adhesiveness that is associated with the exposure of receptors for fibrinogen and, in the presence of sufficient calcium, to aggregate and release the contents of storage granules. These effects of ADP are competitively inhibited by the related nucleotides adenosine 5′-triphosphate (ATP) and adenosine 5′-monophosphate (AMP) which interact with the ADP receptor.1,2

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Authors and Affiliations

  1. Department of Pharmacology, University of London King’s College, Strand, London, WC2R 2LS, UK

    Noel J. Cusack, Susanna M. O. Hourani & Laurence A. Welford

Authors
  1. Noel J. Cusack
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  2. Susanna M. O. Hourani
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  3. Laurence A. Welford
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, London, England

    J. Westwick

  2. Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

    M. F. Scully  & V. V. Kakkar  & 

  3. Department of Pharmacology, University of Glasgow, Glasgow, Scotland

    D. E. MacIntyre

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© 1985 Plenum Press, New York

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Cusack, N.J., Hourani, S.M.O., Welford, L.A. (1985). Characterisation of ADP Receptors. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_3

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  • DOI: https://doi.org/10.1007/978-1-4615-9442-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9444-4

  • Online ISBN: 978-1-4615-9442-0

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