Abstract
Recently, considerable attention has been given to platelet membrane phospholipids that are rich in arachidonic acid. One reason for this is that the liberation of this fatty acid following stimulation of the cell is followed by its rapid conversion into oxygenated products such as prostaglandin endoperoxides and thromboxane A2, which both induce platelet aggregation and constrict arterial blood vessels. Besides this, however, membrane phospholipids that are rich in arachidonic acid also may be converted into other secondary messengers such as diacylglycerol and platelet activating factor (PAF, l-0-alkyl-2-acetyl-sn-glycerophosphocholine (GPC)). In this presentation our recent studies on the nature of the phospholipid precursors of arachidonate and diacylglycerol will be discussed.
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© 1985 Plenum Press, New York
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Smith, J.B., Dangelmaier, C., Purdon, A.D., Mauco, G. (1985). Regulation of Platelet Phospholipid Metabolism. In: Westwick, J., Scully, M.F., MacIntyre, D.E., Kakkar, V.V. (eds) Mechanisms of Stimulus—Response Coupling in Platelets. Advances in Experimental Medicine and Biology, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9442-0_20
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DOI: https://doi.org/10.1007/978-1-4615-9442-0_20
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