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Bile Acids and Cholesterol Absorption

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Liver, Nutrition, and Bile Acids

Part of the book series: NATO ASI Series ((NSSA,volume 90))

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Abstract

The obligatory role of bile acids in the overall efficiency of cholesterol absorption from the intestine has been extensively documented. Prior to 1920, it had already been demonstrated that bile duct ligation[l] or bile diversion[2] in dogs, markedly diminished the capacity of the intestine to absorb cholesterol. In the 1950–s several laboratories reported that interruption of the normal entero-hepatic circulation of bile and its contained bile salts, resulted in a decrease in lipids in the thoracic duct lymph of experimental animals[3,4], a marked reduction in the absorbability of oleic acid and of corn oil fatty acids[4], and a complete cessation of cholesterol absorption into lymph[5-7]. Complimentary data has been reported by others in humans with complete biliary obstruction[8], and in animals and humans using bile acid-sequestering anion exchange resins, such as cholestyramine[9,10].

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  1. School of Medicine and Health Sciences, The George Washington University, Washington, DC, 20037, USA

    George V. Vahouny & Linda L. Gallo

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  1. George V. Vahouny
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  1. Institute of Pharmacology and Pharmacognosy, Milan, Italy

    G. Galli  & E. Bosisio  & 

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Vahouny, G.V., Gallo, L.L. (1985). Bile Acids and Cholesterol Absorption. In: Galli, G., Bosisio, E. (eds) Liver, Nutrition, and Bile Acids. NATO ASI Series, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9427-7_3

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  • DOI: https://doi.org/10.1007/978-1-4615-9427-7_3

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