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Bile Acids and Intestinal Pathophysiology

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Liver, Nutrition, and Bile Acids

Part of the book series: NATO ASI Series ((NSSA,volume 90))

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Abstract

Despite our increased knowledge of the synthesis, secretion and enterohepatic circulation of bile salts, several aspects of the effects of these sterol metabolites on the physiology of the intestine itself have not been emphasized and are poorly understood. This becomes of greater significance when we consider that bile acids, particularly chenodeoxycholic acid and ursodeoxycholic acids, are employed for gallstone therapy; there are several dietary influences on the enterohepatic circulation of bile acids and on bile acid excretion (e.g. fats and dietary fibers); increased colonic bile acid concentrations have been implicated in the promotion of colorectal cancer; and there appears to be an inverse relationship between cholesterolemia and colon cancer.

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Authors and Affiliations

  1. Departments of Biochemistry and Physiology, The George Washington University School of Medicine and Health Sciences, Washington DC, 20037, USA

    George V. Vahouny & Marie M. Cassidy

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  1. George V. Vahouny
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  2. Marie M. Cassidy
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  1. Institute of Pharmacology and Pharmacognosy, Milan, Italy

    G. Galli  & E. Bosisio  & 

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© 1985 Plenum Press, New York

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Vahouny, G.V., Cassidy, M.M. (1985). Bile Acids and Intestinal Pathophysiology. In: Galli, G., Bosisio, E. (eds) Liver, Nutrition, and Bile Acids. NATO ASI Series, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9427-7_10

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  • DOI: https://doi.org/10.1007/978-1-4615-9427-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9429-1

  • Online ISBN: 978-1-4615-9427-7

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