Abstract
This subject includes platelet interaction with the normal vessel wall, injured normal vessels, and injured diseased vessels. Platelets are important in hemostasis; thrombocytopenic animals or patients bleed extensively from injured vessels. Platelets are also involved in the development of thrombi, particularly in the arterial circulation, but to some extent in the venous circulation. In addition, platelets contribute to the vessel wall changes associated with injury. Materials from platelets can increase permeability, or contribute to the repair that involves smooth muscle cell migration and proliferation. In all of these interactions the platelets adhere to surfaces, become adhesive and stick to each other, discharge their granule contents, and synthesize products from arachidonic acid freed from membrane phospholipids.
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© 1985 Plenum Press, New York
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Mustard, J.F. (1985). Platelets, Endothelium and Vessel Injury. In: Cajozzo, A., Perricone, R., Di Marco, P., Palazzolo, P. (eds) Advances in Hemostasis and Thrombosis. Ettore Majorana International Science Series, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9424-6_2
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DOI: https://doi.org/10.1007/978-1-4615-9424-6_2
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