Skip to main content

Effects of Trace Elements on Immunoregulation

  • Chapter
Pharmacology
  • 191 Accesses

Abstract

In the past several decades there has been an increased awareness of the effects of “heavy” metals that act as pollutants of our environment. As greater technological advances in chemical detection and analysis of trace elements have been made, the more widespread has become the concern over exposure to these apparently ubiquitous metals (Chisolm, 1980). Since all elements are potentially toxic according to dose, almost all physiological systems are affected by pharmacological doses of trace elements, including the reticuloendothelial system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adkirts, B., Jr., Luginbuhl, G. H., Miller, F. J., and Gardner, D. E., 1980, Increased pulmonary susceptibility to streptococcal infection following inhalation of manganese oxide, Environ. Res. 23:110.

    Google Scholar 

  • Anonymous, 1972, Lead, airborne lead, in: National Academy of Sciences Perspective p. 330.

    Google Scholar 

  • Badenoch-Jones, P., 1978, Metal activation of macrophages, Ann. Rev. R. Coll. Surgeons 60:211.

    CAS  Google Scholar 

  • Badenoch-Jones, P., Turk, J. L., and Parker, D., 1978, The effects of some aluminum and zirconium compounds on guinea pig peritoneal macrophages and skin fibroblasts in culture, J. Pathol. 124:51.

    PubMed  CAS  Google Scholar 

  • Bakir, F., 1973, Methylmercury poisoning in Iraq: An interuniversity report, Science 181:230.

    PubMed  CAS  Google Scholar 

  • Baiter, N. H., Matarazzo, W. J., Gallagher, K., Monos, D., Strasburg, S., and Gary, I., 1980, Modulation of human lymphocyte transformation by cadmium and lead, in: Trace Substances in Environmental Health (D. D. Hemphill, ed.), pp. 167–174, University of Missouri Press, Columbia.

    Google Scholar 

  • Barltrop, D., Barrett, J. A., and Dingle, J. T., 1971, Subcellular distribution of lead in the rat, J. Lab. Clin. Med. 77:705.

    PubMed  CAS  Google Scholar 

  • Berger, N. A., and Skinner, A. M., 1974, Characterization of lymphocyte transformation induced by zinc ions, J. Cell Biol. 61:45.

    PubMed  CAS  Google Scholar 

  • Bowen, H. J. M., 1979, Environmental Chemistry of the Elements ,Academic Press, New York.

    Google Scholar 

  • Braude, R., Mitchell, K. G., and Pittman, R. J., 1973, A note on cuprous chloride as a feed additive for growing pigs, Anim. Prod. 17:321.

    CAS  Google Scholar 

  • Camakaris, J., Danks, M., Phillips, M., Herd, S., and Mann, J. R., 1982, Copper metabolism in Menke’s syndrome and mottled mouse mutant, in: Inflammatory Diseases and Copper Q. R. J. Sorenson, ed.), pp. 85–96, Humana Press, Clifton, N.J.

    Google Scholar 

  • Caron, G. A., Poutala, S., and Provost, T. T., 1970, Lymphocyte transformation induced by inorganic and organic mercury, Int. Arch. Allergy Appl. Immunol. 37:76.

    PubMed  CAS  Google Scholar 

  • Chisolm, J. J., Jr., 1980, Poisoning from heavy metals (mercury, lead and cadmium), Pediatr. Ann. 9:28.

    Google Scholar 

  • Chvapil, M., 1976, Effects of zinc on cells on biomembranes, Med. Clin. North Am. 60:799.

    PubMed  CAS  Google Scholar 

  • Clarkson, T. W., 1972, Recent advances in the toxicology of mercury with emphasis on alkylmercurials. CRC Cut. Rev. Toxicol. 1:203.

    Google Scholar 

  • Cunningham-Rundles, S., Cunningham-Rundles, C., Dupont, B., and Good, R. A., 1980, Zinc induced activation of human B lymphocytes, Clin. Immunol. Immunopathol. 16:115.

    PubMed  CAS  Google Scholar 

  • Davies, N. T., 1974, Recent studies of antagonistic interactions in the aetiology of trace element deficiency and excess, Proc. Nutr. Soc. 33:293.

    PubMed  CAS  Google Scholar 

  • Debold, H. J., and Elvehjem, C. A., 1953, The effect of feeding high amounts of soluble iron and aluminum salts, Am. J. Physiol. 111:118.

    Google Scholar 

  • Evans, G. W., 1973, Copper homeostasis in the mammalian system, Physiol. Rev. 53:535.

    PubMed  CAS  Google Scholar 

  • Fernandes, G., Nair, M., Onone, K., Tanada, T., Floyd, R., and Good, R. A., 1979, Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice, Proc. Natl. Acad. Sci. USA 76:457.

    PubMed  CAS  Google Scholar 

  • Flink, E. B., 1971, Heavy metal poisoning, in: Cecil-Loeb Textbook of Medicine (C. B. Beeson and W. McDermott, eds.), 13th ed., p. 63, Saunders, Philadelphia.

    Google Scholar 

  • Flynn, A., and Yen, B. R., 1981, Mineral deficiency effects on the generation of cytotoxic T-cells and T-helper cell factors in vitro, J. Nutr. 111:907.

    PubMed  CAS  Google Scholar 

  • Flynn, A., Finke, J. H., and Hilfiker, M. L., 1982, Placental mononuclear phagocytes as a source of interleukin-1, Science 218:475.

    PubMed  CAS  Google Scholar 

  • Fox, M. R., 1976, Protective effects of ascorbic acid against toxicity of heavy metals, Ann. N.Y. Acad. Sci. 258:144.

    Google Scholar 

  • Fraker, P. H., Hass, S. M., and Leucke, R. W., 1977, Effects of zinc deficiency on the immune response of the young adult A/J mouse, J. Nutr. 107:1889.

    PubMed  CAS  Google Scholar 

  • Friberg, L., Piscator, M., Nordberg, G. F., and Kjellstrom, T., 1974, Cadmium in the Environment ,2nd ed., CRC Press, Cleveland, Ohio.

    Google Scholar 

  • Frieden, E., 1978, Modes of metal metabolism in mammals, in: Trace Element Metabolism in Animals (M. Kirchgessner, ed.), pp. 8–14, ATW Freising-Weihenstephan.

    Google Scholar 

  • Frieden, E., 1980, Ceruloplasmin: A multi-functional metaUoprotein of vertebrate plasma, in: Roles of Copper (R. G. Feldman, R. R. Young, and W. P. KoeUa, eds.), pp. 93–124, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Frommer, D. J., 1974, Defective biliary excretion of copper in Wilson’s disease, Gut 15:125.

    PubMed  CAS  Google Scholar 

  • Gallagher, K., Matarazzo, W. J., and Gray, I., 1979, Trace metal modification of immunocompetence. II. Effect of Pb, Cd and Cr on RNA turnover, hemoxolkinase and blastogenesis during B lymphocyte transformation in vitro, Clin. Immunol. Immunopathol. 13:369.

    PubMed  CAS  Google Scholar 

  • Gately, M. K., and Martz, E., 1981, Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. V. Evidence that manganese inhibits a calcium dependent step in programming lysis, Cell. Immunol. 61:78.

    PubMed  CAS  Google Scholar 

  • Graham, J. A., Gardner, D. E., Waters, M. D., and Coffin, D. L., 1975, Effect of trace metals on phagocytosis by alveolar macrophages, Infect. Immun. 11:1278.

    PubMed  CAS  Google Scholar 

  • Graham, J. A., Miller, F. J., Daniels, M. J., Payne, E. A., and Gardner, D. E., 1978, Influence of cadmium, nickel and chromium on primary immunity in mice, Environ. Res. 16:77.

    PubMed  CAS  Google Scholar 

  • Gross, R. L., Osdin, N., Fong, L., and Newberne, P. M., 1979, Depressed immunological function in zinc deprived rats as measured by mitogen response of spleen, thymus and peripheral blood, Am. J. Clin. Nutr. 32:1260.

    PubMed  CAS  Google Scholar 

  • Gunn, S. A., Gould, T. C., and Anderson, W. A. D., 1963, The selective injurious response of testicular and epididymal blood vessels to cadmium and its prevention by zinc, Am. J. Pathol. 42:685.

    PubMed  CAS  Google Scholar 

  • Halsted, J. A., Smith, J. C., Jr., Irwin, M. J., 1974, A conspectus of research on zinc requirements of man, J. Nutr. 104:345.

    PubMed  CAS  Google Scholar 

  • Hart, B. A., 1978, Transport of cadmium by the alveolar macrophage, J. Reticuloendothel. Soc. 24:363.

    PubMed  CAS  Google Scholar 

  • Hart, E. B., Steenbock, H., Waddell, J., and Elvehjem, C. A., 1928, Iron in nutrition. VII. Copper as asupplement to iron for hemoglobin building in the rat, J. Biol. Chem. 77:797.

    CAS  Google Scholar 

  • Hemphill, F. E., Kaeberle, M. L., and Buck, W. B., 1971, Lead suppression of mouse resistance to Salmonella typhimurium, Science 172:1031.

    PubMed  CAS  Google Scholar 

  • Hughes, M. H., 1972, The Inorganic Chemistry of Biological Processes ,Wiley, New York.

    Google Scholar 

  • Kang, K. Y., and Salvaggio, J., 1978, Effects of zirconium and aluminum salts on the alveolar macrophages, Tohoku J. Exp. Med. 126:317.

    PubMed  CAS  Google Scholar 

  • Kang, K. Y., Bice, D., D’Amato, A., Ziskind, N., and Salvaggio, J., 1979, Effects of asbestos and beryllium on release of alveolar macrophage enzymes, Arch. Environ. Health 34:133.

    PubMed  CAS  Google Scholar 

  • Katz, D. H., 1979, Adaptive differentiation of murine lymphocytes: Implications of mechanisms of cell-cell recognition and the regulation of immune responses, Fed. Proc. 38:2065.

    PubMed  CAS  Google Scholar 

  • Kirchner, H., and Ruhl, H., 1970, Stimulation of human peripheral lymphocytes by Zn2+ in vitro, Exp. Cell Res. 61:229.

    PubMed  CAS  Google Scholar 

  • KoUer, L. D., 1979, Some immunological effects of lead, cadmium and methylmercury, Drug Chem. Toxicol. 2:99.

    Google Scholar 

  • KoUer, L. D., and Kovacic, S., 1974, Decreased antibody formation in mice exposed to lead, Nature (London) 150:148.

    Google Scholar 

  • Koller, L. D., and Roan, J. G., 1977, Effects of lead and cadmium on mouse peritoneal macrophages, J. Reticuloendothel. Soc. 21:7.

    PubMed  CAS  Google Scholar 

  • KoUer, L. D., and Roan, J. G., 1980, Response of lymphocytes from lead, cadmium and methylmercury exposed mice in the mixed lymphocyte culture, J. Environ. Pathol. Toxicol. 4:393.

    Google Scholar 

  • KoUer, L. D., Exon, J. H., and Roan, J. G., 1976, Humoral antibody response in mice after single dose exposure to lead or cadmium, Proc. Soc. Exp. Biol. Med. 151:339.

    Google Scholar 

  • KoUer, L. D., Exon, J. H., and Roan, J. G., 1975, Antibody suppression by cadmium, Arch. Environ. Health 30:598.

    Google Scholar 

  • Koller, L. D., Roan, J. G., Brauner, J. A., and Exon, J. H., 1977, Immune response in aged mice exposed to lead, J. Toxicol. Environ. Health 3:535.

    PubMed  CAS  Google Scholar 

  • Koller, L. D., Roan, J. G., and KerkvUet, N. I., 1979, Mitogen stimulation of lymphocytes in CBA mice exposed to lead and cadmium, Environ. Res. 19:177.

    PubMed  CAS  Google Scholar 

  • Lafferty, K. J., Andras, L., and Prowse, S. J., 1980, Role of lymphokine and antigen in the control of specific T-cell response, Immunol. Rev. 51:279.

    PubMed  CAS  Google Scholar 

  • Leach, R. M., Jr., 1976, Metabolism and function of manganese, in: Trace Elements in Human Health and Disease II (A. S. Prasad, ed.), pp. 235–247, Academic Press, New York.

    Google Scholar 

  • Lewis, G. P., Jusko, W. J., and Coughlin, H., 1972, Cadmium accumulation in men: Influence of smoking, occupation, alcoholic habit and disease, J. Chronic Dis. 25:717.

    PubMed  CAS  Google Scholar 

  • Lieben, J., and Williams, R. R., 1969, Respiratory disease associated with beryllium refining and alloy fabrication, . J. Occup. Med. 11:480.

    PubMed  CAS  Google Scholar 

  • Loose, L. D., Silkworth, J. B., and Warrington, D., 1977, Cadmium induced depression of the respiratory burst in mouse pulmonary macrophages, peritoneal macrophages and polymorphonuclear neutrophils, Biochem. Biophys. Res. Commun. 79:326.

    PubMed  CAS  Google Scholar 

  • Loose, L. D., Silkworth, J. B., and Simpson, D. W., 1978, Influence of cadmium on the phagocytic and microbicial activity of murine peritoneal macrophages, pulmonary alveolar macrophages and polymorphonuclear neutrophils, Infect. Immun. 22:378.

    PubMed  CAS  Google Scholar 

  • Lukasewycz, O. A., Prohaska, J. R., Schmidtke, J. R., Hatfield, S. M., Marder, P., and Meyer, S. B., 1982, Alterations in lymphoid subpopulations and mitogen reactivity in copper deficient mice, Fed. Proc. 41:341.

    Google Scholar 

  • Luster, M. I., Faith, R. E., and Kimmel, C. A., 1978, Depression of humoral immunity in rats following chronic developmental lead exposure, J. Environ. Pathol. Toxicol. 1:397.

    PubMed  CAS  Google Scholar 

  • McLaughlin, S. G. A., Szabo, G., and Eisenman, G., 1971, Divalent ions and surface potential of charged phospholipid membranes, J. Gen. Physiol. 58:667.

    PubMed  CAS  Google Scholar 

  • Makker, S. P., and Aikawa, M., 1979, Mesangial glomerulonephropathy with deposition of IgG, IgM and C3 induced by mercuric chloride, Lab. Invest. 41:45.

    PubMed  CAS  Google Scholar 

  • Mapes, C. A., Bailey, P. T., Matson, C. F., Hauer, E. C., and Sobocinski, P. Z., 1978, In vitro and in vivo actions of zinc ion affecting cellular substances which influence host metabolic responses to inflammation, J. Cell Physiol. 95:115.

    PubMed  CAS  Google Scholar 

  • Matrone, G., 1974, Chemical parameters in trace element antagonisms, in: Trace Element Metabolism in Animals II (W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds.), pp. 91–104, University Park Press, Baltimore.

    Google Scholar 

  • Matrone, G., Harman, R. H., and Clawson, A. J., 1959, Studies of manganese iron antagonism in the nutrition of rabbits and baby pigs, J. Nutr. 67:309.

    PubMed  CAS  Google Scholar 

  • Muller, S., Gillert, K. E., Krause, C., Jautzke, G., Gross, U., and Diamantstein, T., 1979, Effects of cadmium on the immune system of mice, Experientia 35:909.

    PubMed  CAS  Google Scholar 

  • Needleman, H. L., Gunnoe, C., Leviton, A., Reed, R., Peresie, H., Mober, C., and Barrett, P., 1979, Psychological performance of children with elevated lead levels, N. Engt. J. Med. 300:689.

    CAS  Google Scholar 

  • Nielsen, F. H., 1974, Essentiality and function of nickel, in: Trace Element Metabolism in Animals II (W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds.), pp. 381–396, University Park Press, Baltimore.

    Google Scholar 

  • North American Contact Dermatitis Group, 1973, Epidemiology of contact dermatitis in North America (1972), Arch. Dermatol. 108:537.

    Google Scholar 

  • North, B. B., Leichseuring, J. M., and Voris, L. M., 1960, Manganese metabolism in college women, J. Nutr. 72:217.

    PubMed  CAS  Google Scholar 

  • Parizek, J., 1964, Vascular changes at sites of oestrogen biosynthesis produced by parenteral injections of cadmium salts: The destruction of placenta by cadmium salts, J. Reprod. Fertil. 7:263.

    PubMed  CAS  Google Scholar 

  • Parizek, J., and Zahor, Z., 1956, Effect of cadmium salts on testicular tissue, Nature (London) 177:1036.

    CAS  Google Scholar 

  • Pedroni, E., Bianchi, E., Ugazio, A. G., and Burgio, G. R., 1975, Immunodeficiency and steely hair, Lancet 1:1303.

    PubMed  CAS  Google Scholar 

  • Perry, H. M., Jr., 1968, Hypertension and trace metals, particularly cadmium, in: Trace Elements in Environmental Health II (D. D. Hemphill, ed.), pp. 101–125, University of Missouri Press, Columbia.

    Google Scholar 

  • Powell, A. L., Joshi, B., Dwivedi, C., and Green, L., 1979, Immunopathological changes in cadmium treated rats, Vet. Pathol. 16:116.

    PubMed  CAS  Google Scholar 

  • Price, C. D., Williams, W. J., Pugh, A., and Joynson, D. H., 1977, Role of in vitro and in vivo tests of hypersensitivity in beryllium workers, J. Clin. Pathol. 30:24.

    PubMed  CAS  Google Scholar 

  • Prohaska, J. R., and Lukasewycz, O. A., 1981, Copper deficiency suppresses the immune response of mice, Science 213:559.

    PubMed  CAS  Google Scholar 

  • Prourost-Danon, A., Abadie, A., Sapin, C., Bazin, H., and Druet, P., 1981, Induction of IgE syn thesis and potentiation of anti-ovalbumin IgE antibody response by HgCl2 in the rat, J. Immunol 126:699.

    Google Scholar 

  • Reeves, A. L., 1976, BeryUiosis as an autoimmune disorder, Ann. din. Lab. Sci. 6:256.

    CAS  Google Scholar 

  • Reigart, J. R., and Graber, C. D., 1976, Evaluation of the humoral immune response of children with low level lead exposure, Bull. Environ. Contam. Toxicol. 16:112.

    PubMed  CAS  Google Scholar 

  • Resnick, H., Roche, M., and Morgan, W. K. C., 1970, Immunoglobulin concentrations in berylliosis, Am. Rev. Respir. Dis. 101:504.

    PubMed  CAS  Google Scholar 

  • Sandstead, H. H., 1973, Zinc nutrition in the United States, Am. J. Clin. Nutr. 26:1251.

    PubMed  CAS  Google Scholar 

  • Sandstead, H. H., and Rinaldi, R. S., 1969, Impairment of deoxyribonucleic acid synthesis by dietary zinc deficiency in the rat, J. Cell. Physiol. 73:81.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A., 1965, Cadmium as a factor in hypertension, J. Chronic Dis. 18:647.

    CAS  Google Scholar 

  • Schroeder, H. A., and Mitchener, MI., 1975, Life-term studies in rats: Effects of aluminum, barium, beryllium and tungsten, J. Nutr. 105:421.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A., and Vinton, W. H., Jr., 1962, Hypertension induced in rats by small doses of cadmium, Am. J. Physiol. 202:515.

    PubMed  CAS  Google Scholar 

  • Schwartz, K., 1974, New essential trace elements (Su, V, F, Si): Progress report and outlook, in: Trace Element Metabolism in Animals II (W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds.), pp. 355–380, University Park Press, Baltimore.

    Google Scholar 

  • Smith, D. W., and Williams, R. J. P., 1970, Structure and Bonding ,Volume 7, Springer-Verlag, Berlin.

    Google Scholar 

  • Smith, K. A., 1980, T-cell growth factor, Immunol. Rev. 51:337.

    PubMed  CAS  Google Scholar 

  • Smith, P. F., 1962, Animal intake of essential elements for various dietary sources, Annu. Rev. Plant Physiol. 13:81.

    CAS  Google Scholar 

  • Smith, T. J., Temple, A. R., and Reading, J. C., 1976, Cadmium, lead and copper blood levels in normal children, Clin. Toxicol. 9:75.

    PubMed  CAS  Google Scholar 

  • Smith, W. E., and Smith, A. M., 1975, Minamata ,Holt, Rinehart & Winston, New York.

    Google Scholar 

  • Sorenson, J. R. J., Campbell, I. R., Tepper, L. B., and Lingg, R. D., 1974, Aluminum in the environment and human health, Environ. Health Perspect. 8:3.

    PubMed  CAS  Google Scholar 

  • Steitz, T. A., Wiley, D. C., and Lipscomb, W. N., 1967, The structure of aspartate transcarbamylase. I. A molecular twofold axis in the complex with cytidine triphosphate, Proc. Natl. Acad. Sci. USA 64:1859.

    Google Scholar 

  • Sterrúieb, I., 1982, Wilson’s disease, in: Inflammatory Diseases and Copper (J. R. J. Sorenson, ed.), pp. 75–84, Humana Press, Oifton, N.J.

    Google Scholar 

  • Sullivan, J. L., and Ochs, H. D., 1978, Copper deficiency and the immune system, Lancet 2:686.

    PubMed  CAS  Google Scholar 

  • Underwood, E. J., 1977, Trace Elements in Human and Animal Nutrition ,4th ed., Academic Press, New York.

    Google Scholar 

  • Utter, M. F., 1976, Biochemistry of manganese, Med. Clin. North Am. 60:713.

    PubMed  CAS  Google Scholar 

  • Vallee, B. L., Riordan, J. F., Johansen, J. T., and Livingston, D. M., 1971, Spectro-chemical probes for protein conformation and function, Cold Spring Harbor Symp. Quant. Biol. 36:517.

    CAS  Google Scholar 

  • Spivey-Fox, M. R., 1978, Nutritional considerations in designing animal models of metal toxicity in man, Environ. Health Physiol. 25:137.

    Google Scholar 

  • Vijay, H. M., Lavergne, G., Huang, H., and Bernstein, I. L., 1979, Preferential synthesis of IgE reaginic antibodies in rats immunized with alum-absorbed antigens, Int. Arch. Allergy Appl. Immunol. 59:227.

    PubMed  CAS  Google Scholar 

  • Williams, H., 1933, Lead poisoning from the burning of battery casings, Am. Med. Assoc. 100:1485.

    CAS  Google Scholar 

  • Witham, I. J., 1963, Depression of cytochrome oxidase activities in livers of zinc intoxicated rats, Biochim. Biophys. Acta 73:509.

    CAS  Google Scholar 

  • Wood, J. M., 1974, Biological cycles for toxic elements in the environment, Science 183:1049.

    PubMed  CAS  Google Scholar 

  • Wu, S., Bach, F. H., and Auerbach, R., 1975, Cell-mediated immunity: Differential maturation of mixed lymphocyte reaction and cell-mediated lympholysis, J. Exp. Med. 142:1301.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Flynn, A. (1985). Effects of Trace Elements on Immunoregulation. In: Hadden, J.W., Szentivanyi, A. (eds) Pharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9406-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9406-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9408-6

  • Online ISBN: 978-1-4615-9406-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics