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On the Multiplicity of Cellular Elastases and their Inefficient Control by Natural Inhibitors

  • Chapter
Proteases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 167))

Abstract

Several elastic tissue diseases are mainly characterized by the conspicuous fragmentation and loss of orientation of the elastic fibers and it is now generally accepted that the degradation of elastin plays a primordial role in the development of human diseases as emphysema and arteriosclerosis1,2. This generalized age-dependent lysis of elastin, which is accelerated under pathological circumstances, has been attributed to the proteolytic action of endopeptidases designated as elastases3. Such an example is the specific degradation of elastin in lung tissue which is considered as a necessary requirement for the experimental induction of emphysema. The severity of the induced lesion is directly related to the elastolytic efficiency of the intratracheally infused protease4.

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Authors and Affiliations

  1. Faculté de Médecine, Labo. de Biochimie du Tissu Conjonctif, GR CNRS n° 40, 8 rue du Gen. Sarrail, 94010, Creteil, France

    W. Hornebeck, D. Brechemier, M. P. Jacob, C. Frances & L. Robert

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  1. W. Hornebeck
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  2. D. Brechemier
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  3. M. P. Jacob
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  4. C. Frances
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  5. L. Robert
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Editors and Affiliations

  1. University of Würzburg, Würzburg, Federal Republic of Germany

    Walter H. Hörl  & August Heidland  & 

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© 1984 Plenum Press, New York

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Hornebeck, W., Brechemier, D., Jacob, M.P., Frances, C., Robert, L. (1984). On the Multiplicity of Cellular Elastases and their Inefficient Control by Natural Inhibitors. In: Hörl, W.H., Heidland, A. (eds) Proteases. Advances in Experimental Medicine and Biology, vol 167. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9355-3_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9355-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9357-7

  • Online ISBN: 978-1-4615-9355-3

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