The Epidemiology and Pathophysiology of Invasive Bacterial Diarrheas

With a Note on Biological Considerations in Control Strategies
  • Gerald T. Keusch


A fundamental distinction among enteric bacterial pathogens involves the capacity of some, but not all, to invade intestinal epithelial cells and multiply within the gut mucosa.1 This property not only affects the epidemiology of these infections and their clinical presentation but also imposes biological constraints on attempts to control their spread among susceptible populations. This paper will consider the epidemiology, pathogenesis, clinical manifestations, and potential nutritional consequences of four distinctive invasive bacterial agents of gastroenteritis, the shigellas, the salmonellas (including the causative agents of the enteric fever syndrome), Yersinia enterocolitica, and Campylobacter jejuni, and will attempt to evaluate control strategies based on the biological attributes of the organisms.


Phage Type Yersinia Enterocolitica Shigella Flexneri Chocolate Milk Shigella Dysenteriae 
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Copyright information

© The United Nations University 1983

Authors and Affiliations

  • Gerald T. Keusch
    • 1
  1. 1.Division of Geographic MedicineTufts University School of MedicineBostonUSA

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