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Direct Nutrient Loss and Diarrhea

  • M. Mujibur Rahaman
  • M. A. Wahed

Abstract

The pathogenesis of malnutrition in diarrheal diseases is the principal theme of this volume. A meeting held in 1976 summarized the literature and drew renewed attention to the infection-nutrition relationship.1 New information on the specific interactions of diarrhea and nutrition is presented in this volume. Reduced dietary intake resulting from partial loss of appetite, lower digestive and absorptive capacity of the gastrointestinal tract caused by enzymatic deficiencies, short transit-time, and morphological changes in the intestinal villi, induced by repeated attacks of diarrheal diseases, are considered to be some of the main causes of malnutrition in tropical developing countries. Catabolic breakdown of body protein because of inflammation also contributes to malnutrition in some invasive diarrheas. There is, however, another cause of malnutrition, brought about by direct loss of nutrients into the gut, that has not so far been investigated adequately, mainly because of technical difficulties involved in its measurement. Loss of protein or other nutrients into the gut in a healthy individual is extremely small; whatever is secreted into the intestine undergoes breakdown and reabsorption. The major protein in the feces is in mucous secretions, undigested food material, and bacteria. Loss from the gastrointestinal tract becomes obvious when the quantity secreted exceeds the capacity of the intestine to reabsorb.

Keywords

Celiac Disease Absorptive Capacity Diarrheal Disease Protein Loss Inflame Colonic Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Proceedings of a symposium: Impact of infection on nutritional status of the host. Am. J. Clin. Nutr. 30: 1203–1369, 1977.Google Scholar
  2. 2.
    Waldman, T. A. Protein-losing enteropathy. In: Modern Trends in Gastroenterology, W. I. Card and B. Creamer (Eds.), pp. 125–142, Butterworths, London, 1970.Google Scholar
  3. 3.
    Rotem, Y, and Czerniak, P. Gastrointestinal protein leakage in celiac disease as studied by labeled PVP. Am. J. Dis. Child. 107:58–66, 1964.Google Scholar
  4. 4.
    Axton, J. H. M. Measles: A protein-losing enteropathy. Br. Med. J. 3:79–80, 1975.CrossRefGoogle Scholar
  5. 5.
    Cohen, H., Metz, J., and Hart, D. Protein-losing gastroenteropathy in kwashiorkor. Lancet i:52, 1962.CrossRefGoogle Scholar
  6. 6.
    Rahaman, M. M., Alam, A. K. M. J., and Islam, M. R. Leukaemoid reaction, haemolytic anaemia, and hypoproteinaemia in severe Shigella dysenteriae type-1 infection. Lancet i:1004, 1974.CrossRefGoogle Scholar
  7. 7.
    Crossley, J. R., and Elliott, R. B. Simple method for diagnosing protein-losing enteropathies. Br. Med. J. 1:428–429, 1977.CrossRefGoogle Scholar
  8. 8.
    Bernier, J. J., Florent, C., Desmazures, C., Aymes, C., and L’Hirondel, C. Diagnosis of protein-losing enteropathy by gastrointestinal clearance of alpha 1-antitrypsin. Lancet ii:763–764, 1978.CrossRefGoogle Scholar
  9. 9.
    Koster, F., Levin, J., Walker, L., Tung, K. S. K., Gilman, R. H., Rahaman, M. M., Majid, M. A., Islam S., and Williams, R. C., Jr. Hemolytic-uremic syndrome after shigellosis. N. Engl. J. Med. 298:927–933, 1978.CrossRefGoogle Scholar
  10. 10.
    Davidson, G. P., Gall, D. G., Petric, M., Butler, D. G., and Hamilton, J. R. Human rotavirus enteritis induced in conventional piglets: Intestinal structure and transport. J. Clin. Invest. 60:1402–1409, 1977.CrossRefGoogle Scholar

Copyright information

© The United Nations University 1983

Authors and Affiliations

  • M. Mujibur Rahaman
    • 1
  • M. A. Wahed
    • 1
  1. 1.International Centre for Diarrhoeal ResearchDaccaBangladesh

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