Abstract
Resumption of meiosis (oocyte maturation) is normally triggered by the preovulatory LH surge, and the first meiotic division is completed at the time of follicle rupture. The mature follicle has receptors for LH both in the theca and granulosa cells but no specific LH receptors have been demonstrated on the oocyte itself. Therefore, the triggering effect of LH on meiosis is likely to be mediated indirectly by an effect on the somatic cell types, probably the granulosa cells. We have studied the mechanism of LH action on meiosis with particular emphasis on the relation to the cumulus cells. In this review we will summarize some of our previous findings as well as report on some new results. We focus on studies where oocyte and cumulus maturation have been studied in relation to metabolic changes (1) of the whole isolated follicle and (2) of the isolated oocyte-cumulus complex.
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© 1982 Plenum Press, New York
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Hillensjö, T., Magnusson, C., Ekholm, C., Billig, H., Hedin, L. (1982). Role of Cumulus Cells in Oocyte Maturation. In: Channing, C.P., Segal, S.J. (eds) Intraovarian Control Mechanisms. Advances in Experimental Medicine and Biology, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9278-5_11
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DOI: https://doi.org/10.1007/978-1-4615-9278-5_11
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