Skip to main content

Immunopathology of Malignant Disease in Mice Leukemias and Lymphomas, Stalking-Horses for Human Counterparts

  • Chapter
  • 38 Accesses

Abstract

The last 20 years have seen a veritable explosion in our knowledge about both animal and human tumors of the lymphoid and hemopoietic systems. Today, a bewildering amount of detailed information is available about the causes, varieties, and therapies of these tumors. The challenge for us all is to obtain a coherent overview of this forest of information, which will allow us to recognize individual trees as members of a particular grove, and to know the location of the empty tracts in which future generations may plant their trees.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ades, E. W., Zwerner, R. K., Acton, R. T., and Balch, C. M., 1980, Isolation and partial characterization of the human homologue of Thy-1, J. Exp. Med. 151:400.

    Article  PubMed  CAS  Google Scholar 

  • Argyris, B. F., 1978, Activation of suppressor cells by syngeneic tumor transplants in mice. Cancer Res. 38:1269.

    PubMed  CAS  Google Scholar 

  • Argyris, T. S., and Slaga, T. J., 1981, Promotion of carcinomas by repeated abrasion in initiated skin of mice, Cancer Res. 41:5193.

    PubMed  CAS  Google Scholar 

  • Baird, S. M., Beattie, G. M., Lannom, R. A., Lipsick, J. S., Jensen, F. C., and Kaplan, N. O., 1982, Induction of lymphoma in antigenically stimulated athymic mice, Cancer Res. 42:198.

    PubMed  CAS  Google Scholar 

  • Baltimore, D., 1980, “Viruses and Cancer,” Weinstein Lectureship, Tufts Medical School, April 15.

    Google Scholar 

  • Bekesi, J. G., Roboz, J. P., Zimmerman, E., and Holland, J. F., 1976, Treatment of spontaneous leukemia in AKR mice with chemotherapy, immunotherapy, or interferon, Cancer Res. 36:631–639.

    PubMed  CAS  Google Scholar 

  • Benacerraf, B., 1981, Role of MHC gene products in immune regulation, Science 212:1229.

    Article  PubMed  CAS  Google Scholar 

  • Benacerraf, B., and Germain, R. N., 1978, The immune response genes of the major histocompatibility complex, Immunol. Rev. 38:70.

    Article  PubMed  CAS  Google Scholar 

  • Bloomfield, C. D., Gajl-Peczalska, K. J., Frizzera, G., Kersey, J. H., and Goldman, A. I., 1979, Clinical utility of surface markers combined with the Lukes-Collins histologic classification in adult lymphoma, N. Engl. J. Med. 301:512.

    Article  PubMed  CAS  Google Scholar 

  • Boyd, A. W., Goding, J. W., and Schrader, J. W., 1981, The regulation of growth and differentiation of a murine B cell lymphoma. I. Lipopolysaccharide-induced differentiation, J. Immunol. 126:1261.

    Google Scholar 

  • Broder, S., and Waldmann, T. A., 1978a, The suppressor-cell network in cancer, N. Engl. J. Med. 299:1281.

    Article  PubMed  CAS  Google Scholar 

  • Broder, S., and Waldmann, T. A., 1978b, The suppressor-cell network in cancer, N. Engl. J. Med. 299:1335.

    Article  PubMed  CAS  Google Scholar 

  • Broder, S., Muul, L., and Waldmann, T. A., 1978, Suppressor cells in neoplastic disease, J. Natl. Cancer Inst. 61:5.

    PubMed  CAS  Google Scholar 

  • Burnet, F. M., 1970, Immunological Surveillance, Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Clapp, N. K., 1973, An Atlas of RF Mouse Pathology: Disease Description and Incidences, Atomic Energy Commission Report UC-48, Springfield, Va.

    Google Scholar 

  • Davey, G. C., Currie, G. A., and Alexander, P., 1979, A serologically detected tumour-specific membrane antigen of murine lymphomas which is not the target for syngeneic graft rejection, Br. J. Cancer 40:168.

    Article  PubMed  CAS  Google Scholar 

  • De Noronha, F., Schäfer, W., Essex, M., and Bolognesi, D. P., 1978, Influence of antisera to oncornavirus glycoprotein (gp71) on infections of cats with feline leukemia virus, Virology 85:617.

    Article  PubMed  Google Scholar 

  • Dent, P. B., 1972, Immunodepression by oncogenic viruses, Prog. Med. Virol. 14:1.

    PubMed  CAS  Google Scholar 

  • DiStefano, J. F., Beck, G., Lane, B., and Zucker, S., 1982, Role of tumor cell membrane-bound serine proteases in tumor-induced target cytolysis, Cancer Res. 42:207.

    PubMed  CAS  Google Scholar 

  • Dunn, T. B., 1954, Normal and pathological anatomy of the reticular tissue in laboratory mice, J. Natl. Cancer Inst. 14:1281.

    PubMed  CAS  Google Scholar 

  • Dunn, T. B., 1963, Histology of some neoplasms and non-neoplastic lesions found in wild mice maintained under laboratory conditions, J. Natl. Cancer Inst. 31:873.

    PubMed  CAS  Google Scholar 

  • Essex, M., Klein, G., Snyder, S. P., and Harrold, J. B., 1971, Correlation between humoral antibody and regression of tumours induced by feline sarcoma virus, Nature (London) 233:195.

    Article  CAS  Google Scholar 

  • Essex, M., Grant, C. K., Sliski, S. M., and Hardy, W. D., Jr., 1979, Leukemia specific antigens: FOCMA and immune surveillance, in: Modern Trends in Leukemia III (N. Neth, R. C. Gallo, P.-H. Hofschneider, and K. Mannweiler, eds.), pp. 454–467, Springer-Verlag, Berlin.

    Google Scholar 

  • Evans, R., and Alexander, P., 1970, Cooperation of immune lymphoid cells with macrophages in tumor immunity, Eur. J. Cancer 6:620.

    Google Scholar 

  • Evans, R., and Alexander, P., 1976, Mechanisms of extracellular killing of nucleated mammaliancells by macrophages, in: Immunology of the Macrophage (D. S. Nelson, ed.), pp. 535–576, Academic Press, New York.

    Google Scholar 

  • Feeney, M., Knapp, R. C., Greenberger, J. S., and Bast, R. C., Jr., 1981, Elimination of leukemic cells from rat bone marrow using antibody and complement, Cancer Res. 41:3331.

    PubMed  CAS  Google Scholar 

  • Fish, D. C., Gilden, R. V., Bare, R. M., Trimmer, R. M., and Huebner, R. J., 1979, Prevention of spontaneous leukemia in AKR mice by passive immunization and type specificity of this protection, J. Natl. Cancer Inst. 62:943.

    PubMed  CAS  Google Scholar 

  • Frei, E., III, 1972, Combination cancer therapy: Presidential address, Cancer Res. 32:2593.

    PubMed  Google Scholar 

  • Friedman, H., 1975a, Immunosuppression by murine leukemia viruses, in: Viruses and Immunity (C. Koprowski and H. Koprowski, eds.), pp. 17–47, Academic Press, New York.

    Google Scholar 

  • Friedman, H. (ed.), 1975b, Thymus Factors in Immunity, Ann. N.Y. Acad. Sci. 249:1.

    Google Scholar 

  • Friedman, H. (ed.), 1979, Conference on Subcellular Factors in Immunity, Ann. N.Y. Acad. Sci. 332:1.

    Google Scholar 

  • Furth, J., 1946, Prolongation of life with prevention of leukemia by thymectomy in mice, J. Gerontol. 1:46.

    Article  PubMed  CAS  Google Scholar 

  • Furth, J., Okano, H., and Kunii, A., 1964, Role of the thymus in leukemogenesis, in: The Thymus in Immunobiology (R. A. Good and A. E. Gabrielson, eds.), pp. 595–622, Harper & Row, New York.

    Google Scholar 

  • Geering, C., Old, L. J., and Boyse, E. A., 1966, Antigens of leukemias induced by naturally occurring murine leukemia virus: Their relation to antigens of Gross virus and other murine leukemia viruses, J. Exp. Med. 124:753.

    Article  PubMed  CAS  Google Scholar 

  • George, S. L., Aur, R. J. A., Mauer, A. M., and Simone, J. V., 1979, A reappraisal of the results of stopping therapy in childhood leukemia, N. Engl. J. Med. 300:269.

    Article  PubMed  CAS  Google Scholar 

  • Gershwin, M. E., Castles, J. J., Ahmed, A., and Makishima, R., 1978, The influence of α-fetoprotein on Moloney sarcoma virus oncogenesis: Evidence for generation of antigen nonspecific suppressor T cells, J. Immunol. 121:2292.

    PubMed  CAS  Google Scholar 

  • Goldfeder, A., Kauffman, S. L., and Ghosh, A. K., 1966, Carcinogenesis in naturally tumour-resistant mice: X-Irradiation versus urethane as a carcinogenic agent, Br. J. Cancer 20:361.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, G., Scheid, M. P., Boyse, E. A., Schlesinger, D. H., and Wauwe, J. V., 1979. A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin, Science 204:1309.

    Article  PubMed  CAS  Google Scholar 

  • Good, R. A., 1975, Clinical implications of the data base concerning the tumor-host relationship, in: Immunobiology of the Tumor-Host Relationship (R. T. Smith and M. Landy, eds.), pp. 277–301, Academic Press, New York.

    Google Scholar 

  • Greaves, M. F., 1981, Monoclonal antibodies as probes for leukaemic heterogeneity and haemopoietic differentiation, in: Leukemia Markers (W. Knapp, ed.), pp. 19–32, Academic Press, New York.

    Google Scholar 

  • Greene, M. I., Dorf, M. E., Pierres, M., and Benacerraf, B., 1977, Reduction of syngeneic tumor growth by an anti-I-J alloantiserum, Proc. Natl. Acad. Sci. USA 74:5118.

    Article  PubMed  CAS  Google Scholar 

  • Gross, L., 1951, Pathogenic properties, and “vertical transmission” of the mouse leukemia agent, Proc. Soc. Exp. Biol. Med. 78:342.

    PubMed  CAS  Google Scholar 

  • Gross, L., 1959, Effect of thymectomy on development of leukemia in C3H mice inoculated with leukemia “passage” virus, Proc. Soc. Exp. Biol. Med. 100:325.

    PubMed  CAS  Google Scholar 

  • Gross, L., 1970, Oncogenic Viruses, 2nd ed., Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Gross, L., 1974, The role of viruses in the etiology of cancer and leukemia, J. Am. Med. Assoc. 230:1029.

    Article  CAS  Google Scholar 

  • Hassan, Z. M., and Reese, R. C., 1980, Natural cytotoxicity towards tumor cells: Killing by adherent phagocytic lymph node cells of C57B1 mice, Prepr. Br. Soc. Immunol, Spring, p. 33.

    Google Scholar 

  • Henney, C. S., 1977, Mechanism of tumor cell destruction, in: Mechanisms of Tumor Immunity (I. Green, S. Cohen, and R. T. McCluskey, eds.), pp. 55–86, Wiley, New York.

    Google Scholar 

  • Herberman, R. H., and Ortaldo, J. R., 1981, Natural killer cells: Their role in defenses against disease, Science 214:24.

    Article  PubMed  CAS  Google Scholar 

  • Hethcote, H. W., and Knudson, A. G., Jr., 1978, Model for the incidence of embryonal cancers: Application to retinoblastoma, Proc. Natl. Acad. Sci. USA 75:2453.

    Article  PubMed  CAS  Google Scholar 

  • Hill, M., and Hillova, J., 1976, Genetic transformation of animal cells with viral DNA of RNA tumor viruses, Adv. Cancer Res. 23:237.

    Article  PubMed  CAS  Google Scholar 

  • Hopper, D. G., and Pimm, M. V., 1977, Antitumour effects of macrophages in BCG contact therapy of rat tumours, in: The Macrophage and Cancer (K. James, B. McBride, and A. Stuart, eds.), pp. 182–187, Econoprint, Edinburgh.

    Google Scholar 

  • Huebner, R. J., Gilden, R. V., Toni, R., Hill, R. W., Trimmer, R. W., Fish, D. C., and Sass, B., 1976, Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes, Proc. Natl. Acad. Sci. USA 73:4633.

    Article  PubMed  CAS  Google Scholar 

  • Hugoson, G., Lageröf, B., and Thorell, B., 1977, The effect of chronic protozoan infection by Babesia rodhaini on leukemogenesis in mice, Int. J. Cancer 20:947.

    Article  PubMed  CAS  Google Scholar 

  • Humphrey, J. H., and White, R. G., 1970, Immunology for Students of Medicine, 3rd ed., pp. 7–8, Davis, Philadelphia.

    Google Scholar 

  • Ihle, J. N., Charman, H., and Gilden, R. V., 1980, Comparative biology of mammalian retroviruses, Cancer Biol. Rev. 1:133.

    CAS  Google Scholar 

  • James, K., 1977, The influence of tumour cell products on macrophage function in vitro and in vivo: A review, in: The Macrophage and Cancer (K. James, B. McBride, and A. Stuart, eds.), pp. 225–246, Econoprint, Edinburgh.

    Google Scholar 

  • Jansson, B., and Révész, L., 1976, A deductive approach to the analysis of the growth of ascites tumor cell populations, in: Methods in Cancer Research, Vol. 13 (H. Busch, ed.), pp. 227–299, Academic Press, New York.

    Google Scholar 

  • Kaiser, C. W., and Reif, A. E., 1975, Immunological monitoring and adjuvant immunotherapy of selected cancer patients, in: Immunity and Cancer in Man: An Introduction (A. E. Reif, ed.), pp. 19–46, Dekker, New York.

    Google Scholar 

  • Kaplan, H. S., 1967, On the natural history of the murine leukemias: Presidential address, Cancer Res. 27:1325.

    PubMed  CAS  Google Scholar 

  • Kaplan, H. S., 1974, Leukemia and lymphoma in experimental and domestic animals, Ser. Haematol. 7:94.

    PubMed  CAS  Google Scholar 

  • Kaplan, H. S., 1977, Interaction between radiation and viruses in the induction of murine thymic lymphomas and lymphatic leukemias, in: Radiation-Induced Leukemogenesis and Related Viruses (J. F. Duplan, ed.), pp. 1–17, North-Holland, Amsterdam.

    Google Scholar 

  • Kaplan, H. S., Hirsch, B. B., and Brown, M. R., 1956, Indirect induction of lymphomas in irradiated mice. IV. Genetic evidence of the origin of the tumor cells from thymic grafts, Cancer Res. 16:434.

    PubMed  CAS  Google Scholar 

  • Kapp, J. A., Pierce, C. W., Theze, J., and Benacerraf, B., 1978, Modulation of immune responses by suppressor T cells, Fed. Proc. 37:2361.

    PubMed  CAS  Google Scholar 

  • Kassel, R. L., and Old, L. J. 1976, Plasma-mediated leukemia cell destruction. I. Stabilization and concentration of the active fraction, Proc. Am. Assoc. Cancer Res. 17:172.

    Google Scholar 

  • Kassel, R. L., Old, L. J., Carswell, E. A., Fiore, N. C., and Hardy, W. D., Jr., 1973, Serum mediated leukemia cell destruction in AKR mice, J. Exp. Med. 138:925.

    Article  PubMed  CAS  Google Scholar 

  • Keller, R., 1979, A consideration of the involvement of mononuclear phagocytes in tumor resistance, in: Current Trends in Tumor Immunology (S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 121–138, Garland STPM Press, New York.

    Google Scholar 

  • Kindred, B., Bösing-Schneider, R., and Corley, R. B., 1979, In vivo activity of a nonspecific T cell-replacing factor, J. Immunol. 122:350.

    PubMed  CAS  Google Scholar 

  • Klein, G., 1975, Immunological surveillance against neoplasia, in: The Harvey Lectures, Series 69, pp. 71–102, Academic Press, New York.

    Google Scholar 

  • Klein, G., 1980. Immune and non-immune control of neoplastic development: Contrasting effects of host and tumor evolution, Cancer 45:2486.

    Article  PubMed  CAS  Google Scholar 

  • Klein, J., 1975, Biology of the Mouse Histocompatibility-2 Complex, Springer-Verlag, Berlin.

    Book  Google Scholar 

  • Knudson, A. G., Jr., 1977, Genetics and etiology of human cancer, Adv. Hum. Genet. 8:1.

    PubMed  CAS  Google Scholar 

  • Kobayashi, H., Takeichi, N., and Kuzumaki, N., 1978, Xenogenization of Lymphocytes, Erythroblasts, and Tumor Cells, Hokkaido University Medical Library Series, Vol. 10, Hokkaido University School of Medicine, Hokkaido.

    Google Scholar 

  • Koeffler, H. P., and Golde, D. W., 1981, Chronic myelogenous leukemia—New concepts, N. Engl. J. Med. 304:1201.

    Article  PubMed  CAS  Google Scholar 

  • Köhler, G., and Milstein, C., 1975, Continuous cultures of fused cells secreting antibodies of predefined specificity, Nature (London) 256:495.

    Article  Google Scholar 

  • Kumar, V., Goldschmidt, L., Eastcott, J. W., and Bennett, M., 1978, Mechanisms of genetic resistance to Friend virus leukemia in mice. IV. Identification of a gene (Fv-3) regulating immunosuppression in vitro, and its distinction from Fv-2 and genes regulating marrow allograft reactivity, J. Exp. Med. 147:422.

    Article  PubMed  CAS  Google Scholar 

  • Kurth, R., Fenyö, E. M., Klein, E., and Essex, M., 1979, Cell-surface antigens induced by RNA tumour viruses, Nature (London) 279:197.

    Article  CAS  Google Scholar 

  • Lala, P. K., 1971, Studies on tumor cell population kinetics, in: Methods in Cancer Research, Vol. 6 (H. Busch, ed.), pp. 3–95, Academic Press, New York.

    Google Scholar 

  • Leventhal, B. G., Civin, C. I., and Reaman, G., 1980, Markers in human lymphoid tumors, in: Cancer Markers (S. Sell, ed.), pp. 89–113, Humana Press, Clifton, N.J.

    Chapter  Google Scholar 

  • Levinthal, J. D., Buffett, R. F., and Furth, J., 1959, Prevention of viral leukemia of mice by thymectomy, Proc. Soc. Exp. Biol. Med. 100:610.

    PubMed  CAS  Google Scholar 

  • Levy, M. H., and Wheelock, E. F., 1974, The role of macrophages in defense against neoplastic disease, Adv. Cancer Res. 20:131.

    Article  PubMed  CAS  Google Scholar 

  • Law, L. W., and Miller, J. H., 1950, Observations on the effect of thymectomy on spontaneous leukemias in mice of high leukemia strains RIL and C58, J. Natl. Cancer Inst. 11:253.

    PubMed  CAS  Google Scholar 

  • Likhite, V. V., 1978, Review of tumor enchancement, in: The Handbook of Cancer Immunology, Vol. 4 (H. Waters, ed.), pp. 235–276, Garland STPM Press, New York.

    Google Scholar 

  • Lilly, F., and Pincus, T., 1973, Genetic control of murine viral leukemogenesis, Adv. Cancer Res. 17:231.

    Article  Google Scholar 

  • Lilly, F., Boyse, A. E., and Old, L. J., 1964, Genetic basis of viral leukemogenesis, Lancet 2:1207.

    Article  PubMed  CAS  Google Scholar 

  • Lilly, F., Duran-Reynals, M. L., and Rowe, W. P., 1975, Correlation of early murine leukemia virus titer and H-2 type of spontaneous leukemia in mice of the BALB x AKR cross: A genetic analysis, J. Exp. Med. 141:882.

    PubMed  CAS  Google Scholar 

  • Louie, S., Daoust, P. R., and Schwartz, R. S., 1980, Immunodeficiency and the pathogenesis of non-Hodkins lymphoma, Semin. Oncol. 7:267.

    PubMed  CAS  Google Scholar 

  • Magrath, I. T., 1981, Lymphocyte differentiation: An essential basis for the comprehension of lymphoid neoplasia, J. Natl. Cancer Inst. 67:501.

    PubMed  CAS  Google Scholar 

  • Marshak-Rothstein, A., Fink, P., Gridley, T., Raulet, D. H., Bevan, M. J., and Gefter, M. L., 1979, Properties and applications of monoclonal antibodies directed against determinants of the Thy-1 locus, J. Immunol. 122:2491.

    PubMed  CAS  Google Scholar 

  • Mathé, G., Pouillart, P., and Lapeyraque, F., 1969, Active immunotherapy of L1210 leukemia applied after the graft of tumor cells, Brit. J. Cancer 23:814–824.

    Article  PubMed  Google Scholar 

  • McBride, W. H., Peters, L. J., Mason, K. A., Barrow, G., and Milas, L., 1977, In vivo anti-tumour activity of C. parvum stimulated peritoneal exudate cells, in: The Macrophage and Cancer (K. James, B. McBride, and A. Stuart, eds.), pp. 173–181, Econoprint, Edinburgh.

    Google Scholar 

  • Mendelsohn, M. L., 1969, Cell cycle kinetics and mitotically linked chemotherapy, Cancer Res. 29:1390.

    Google Scholar 

  • Meruelo, D., Nimelstein, S. H., Jones, P. P., Lieberman, M., and McDevitt, H. O., 1978, Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: A possible mechanism for H-2 linked control of virus-induced neoplasia, J. Exp. Med. 147:470.

    Article  PubMed  CAS  Google Scholar 

  • Metcalf, D., 1956, The thymic origin of the plasma lymphocytosis stimulating factor, Br. J. Cancer 10:442.

    Article  PubMed  CAS  Google Scholar 

  • Metcalf, D., 1964, Functional interactions between the thymus and other organs, in: The Thymus (D. Metcalf, V. Defendi, and H. Koprowski, eds.), pp. 53–73, Wistar Institute Press, Philadelphia.

    Google Scholar 

  • Metcalf, D., 1966, Histologic and transplantation studies on preleukemic thymus of the AKR mouse, J. Natl. Cancer Inst. 37:425.

    PubMed  CAS  Google Scholar 

  • Mikulski, S. M., and Muggia, F. M., 1978, The suppressor mechanisms and their significance in tumor immunology, Cancer Immunol. Immunother. 4:139.

    Article  Google Scholar 

  • Milas, L., and Scott, M. T., 1978, Antitumor activity of Corynebacterium parvum, in: Advances in Cancer Research, Vol. 26 (G. Klein and S. Weinhouse, eds.), pp. 257–306, Academic Press, New York.

    Chapter  Google Scholar 

  • Miller, J. F. A. P., 1959, Fate of subcutaneous thymus grafts in thymectomized mice inoculated with leukemic filtrate, Nature (London) 184: 1809.

    Article  Google Scholar 

  • Mogensen, S. C., 1979, Role of macrophages in natural resistance to virus infections, Microbiol. Rev. 43:1.

    PubMed  CAS  Google Scholar 

  • Murphy, E. D., 1966, Characteristic tumors, in: Biology of the Laboratory Mouse (E. L. Green, ed.), pp. 521–562, McGraw-Hill, New York.

    Google Scholar 

  • Nadler, L. M., Ritz, J., Reinherz, E. L., and Schlossman, S. F., 1981, Cellular origins of human leukemias and lymphomas, in: Leukemia Markers (W. Knapp, ed.), pp. 3–17, Academic Press, New York.

    Google Scholar 

  • Nelson, D. S., 1976, Macrophages: Perspectives and prospects, in: Immunology of the Macrophage (D. S. Nelson, ed.), pp. 617–621, Academic Press, New York.

    Google Scholar 

  • Normann, S. J., Schardt, M., and Sorkin, E., 1977, Do tumors escape surveillance by depression of macrophage inflammation?, in: The Macrophage and Cancer (K. James, B. McBride, and A. Stuart, eds.), pp. 247–257, Econoprint, Edinburgh.

    Google Scholar 

  • Nossal, G. J. V., and Gorrie, J., 1964, Studies on the emigration of thymic cells in young guinea pigs, in: The Thymus in Immunobiology (R. A. Good and A. E. Gabrielsen, eds.), pp. 288–290, Harper & Row, New York.

    Google Scholar 

  • Old, L. J., 1981, Cancer immunology: The search for specificity—G. H. A. Clewes memorial lecture, Cancer Res. 41:361.

    PubMed  CAS  Google Scholar 

  • Old, L. J., and Boyse, E. A., 1964, Immunology of experimental tumors, Annu. Rev. Med. 15:167.

    Article  PubMed  CAS  Google Scholar 

  • Old, L. J., and Stockert, E., 1977, Immunogenetics of cell surface antigens of mouse leukemia, Annu. Rev. Genet. 11:127.

    Article  PubMed  CAS  Google Scholar 

  • Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E., and Stockert, E., 1961, The role of the endothelial system in the host reaction to neoplasia, Cancer Res. 21:1281.

    PubMed  CAS  Google Scholar 

  • Old, L. J., Boyse, E. A., Clarke, D. A., and Carswell, E. A., 1962, Antigenic properties of chemically induced tumors, Ann. N.Y. Acad. Sci. 101:80.

    Article  CAS  Google Scholar 

  • Parkinson, D. R., Schwartz, R. S., and Sutherland, D. C., 1981, Viruses, genes and lymphoma, Contemp. Hematol. Oncol. 2:467.

    Google Scholar 

  • Penn, I., and Starzl, T. E., 1973, The effect of immunosuppression on cancer, in: Seventh National Cancer Conference Proceedings, pp. 425–436, Lippincott, Philadelphia.

    Google Scholar 

  • Perkins, E. H., and Cacheiro, L. H., 1980, Immunodepression, a noncontributor to radiation-induced leukemogenesis of the RFM mouse, Cancer Res. 40:357.

    PubMed  CAS  Google Scholar 

  • Perry, L. L., Benacerraf, B., and Greene, M. I., 1978, Regulation of the immune response to tumor antigen. IV. Tumor antigen-specific suppressor factor(s) bear I-J determinants and induce suppressor T cells in vivo, J. Immunol. 121:2144.

    CAS  Google Scholar 

  • Persson, U., Hammarström, L., Möller, E., Möller, G., and Smith, C. T. E., 1978, The role of adherent cells in B and T lymphocyte activation, Immunol. Rev. 40:78.

    Article  PubMed  CAS  Google Scholar 

  • Pierce, G. B., and Johnson, L. D., 1971, Differentiation and cancer, In Vitro 7:140.

    Article  PubMed  CAS  Google Scholar 

  • Pitot, H. C., 1978, Fundamentals of Oncology, Dekker, New York.

    Google Scholar 

  • Prager, M. D., and Baechtel, F. S., 1973, Methods for modification of cancer cells to enhance their antigenicity, in: Methods in Cancer Research (H. Busch, ed.), pp. 339–400, Academic Press, New York.

    Google Scholar 

  • Prehn, R. T., 1976, Tumor progression and homeostasis, Adv. Cancer Res. 23:203.

    Article  PubMed  CAS  Google Scholar 

  • Raabe, O. G., Book, S. A., and Parks, N. J., 1980, Bone cancer from radium: Canine dose response explains data for mice and humans, Science 208:61.

    Article  PubMed  CAS  Google Scholar 

  • Rappaport, H., and Baroni, C., 1962, A study of the pathogenesis of malignant lymphoma induced in the Swiss mouse by 7,12-dimethylbenz(a)anthracene injected at birth, Cancer Res. 22: 1067.

    CAS  Google Scholar 

  • Reif, A. E., 1961, Radiation carcinogenesis at high dose-response levels: A hypothesis, Nature (London) 190:415.

    Article  CAS  Google Scholar 

  • Reif, A. E., 1975, Immune defenses against initiation of tumors, in: Immunity and Cancer in Man: An Introduction (A. E. Reif, ed.), pp. 1–18, Dekker, New York.

    Google Scholar 

  • Reif, A. E., 1978, Evidence for organ specificity of defenses against tumors, in: The Handbook of Cancer Immunology, Vol. 1 (H. Waters, ed.), pp. 173–249, Garland STPM Press, New York.

    Google Scholar 

  • Reif, A. E., 1981a, Effect of cigarette smoking on susceptibility to lung cancer, Oncology 38:76.

    Article  PubMed  CAS  Google Scholar 

  • Reif, A. E., 1981b, The causes of cancer, Am. Sci. 69:437.

    PubMed  CAS  Google Scholar 

  • Reif, A. E., and Allen, J. M. V., 1964, The AKR thymic antigen and its distribution in leukemias and nervous tissues, J. Exp. Med. 120:413.

    Article  PubMed  CAS  Google Scholar 

  • Reif, A. E., and Allen, J. M., 1966, The antigenic stability of 3 AKR leukemias on isotransplantation and the serologic detection of thymus-derived leukemia cells, Cancer Res. 26:123.

    PubMed  CAS  Google Scholar 

  • Reif, A. E., and Kim, C.-A. H., 1971a, Leukemia L1210 trials with antileukemia serum and Bacillus Calmette-Guérin, Cancer Res. 31:1606.

    PubMed  CAS  Google Scholar 

  • Reif, A. E., and Kim, C.-A. H., 1971b, Specificity of rabbit antisera against mouse leukaemia cells in vitro, Immunology 20:1087.

    CAS  Google Scholar 

  • Robinson, M. K., Manly, K. F., and Evans, M. J., 1980, Immunosuppression by 334C murine leukemia virus: Viral specificity and the activation of immunosuppressive effects during cloned viral leukemogenesis, J. Immunol. 124:1022.

    PubMed  CAS  Google Scholar 

  • Roder, J. C., and Kiessling, R., 1979, Natural killer cells: Genetic control, specificity, and the mechanism of target cell recognition, in: Current Trends in Tumor Immunology (S. Ferrone, S. Gorini, R. B. Herberman, and R. A. Reisfeld, eds.), pp. 31–47, Garland STPM Press, New York.

    Google Scholar 

  • Rotter, V., and Trainin, N., 1979, Role thymic hormone (THF) and of a thymic plasma recirculating factor (TPRF) in the modulation of human lymphocyte response to PHA and Con A, J. Immunol. 122:414.

    PubMed  CAS  Google Scholar 

  • Rowe, W. P., Hartley, J. W., and Kozak, C. A., 1981, in: The Jackson Laboratory Fiftieth Anniversary Symposium (E. S. Russell, ed.), pp. 291–295, Liss, New York.

    Google Scholar 

  • Sainte-Marie, G., 1973, Cell migration and the thymus, in: Contemporary Topics in Immunobiology, Vol. 2 (A. J. S. Davies and R. L. Carter, eds.), pp. 111–117, Plenum Press, New York.

    Chapter  Google Scholar 

  • Saxon, A., Stevens R. H., and Golde, D. W., 1979, Helper and suppressor T-lymphocyte leukemia in ataxia telangiectasia, N. Engl. J. Med. 300:700.

    Article  PubMed  CAS  Google Scholar 

  • Schäfer, W., Schwarz, H., Thiel, H.-J., Fischinger, P. J., and Bolognesi, D. P., 1977, Properties of mouse leukemia viruses. XIV. Prevention of spontaneous AKR leukemia by treatment with group-specific antibody against the major virus gp71 glycoprotein, Virology 83:207.

    Article  PubMed  Google Scholar 

  • Schocket, A. L., Malesky, E. V., and Köhler, P. F., 1981, Lymphocytotoxic antibodies in cancer, Cancer Immunol. Immunother. 12:43.

    Article  Google Scholar 

  • Schwartz, R. S., 1975, Another look at immunological surveillance, N. Engl. J. Med. 293:181.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, J., Monticone, V., and Paetkau, V., 1978, Partial purification and molecular characterization of a lymphokine (costimulator) required for the mitogenic response of mouse thymocytes in vitro, J. Immunol. 120:1967.

    CAS  Google Scholar 

  • Siegel, B. V., 1978, Tumor immunity: An overview, Am. J. Pathol. 93:515.

    PubMed  CAS  Google Scholar 

  • Siegler, R., and Rich, M. A., 1963, Unilateral histogenesis of AKR thymic lymphoma, Cancer Res. 23:1669.

    PubMed  CAS  Google Scholar 

  • Siegler, R. S., Geldner, J., and Rich, M. A., 1964, Histogenesis of thymic lymphoma induced by a murine leukemia virus (Rich), Cancer Res. 24:444.

    PubMed  CAS  Google Scholar 

  • Skipper, H. E., 1968, Cellular kinetics associated with “curability” of experimental leukemias, in: Perspective in Leukemia (W. Dameshek and R. M. Dutcher, eds.), pp. 187–216, Grune & Stratton, New York.

    Google Scholar 

  • Skipper, H. E., 1971, Cancer chemotherapy is many things—Clowes memorial lecture, Cancer Res. 31:1173.

    PubMed  CAS  Google Scholar 

  • Smith, C., 1964, The microscopic anatomy of the thymus, in: The Thymus in Immunobiology (R. A. Good and A. E. Gabrielsen, eds.), pp. 71–84, Harper & Row, New York.

    Google Scholar 

  • Snell, G. D., 1978, T cells, T cell recognition structures, and the major histocompatibility complex, Immunol. Rev. 38:3.

    Article  PubMed  CAS  Google Scholar 

  • Snell, G. D., Dausset, J., and Nathenson, S., 1976, Histocompatibility, Academic Press, New York.

    Google Scholar 

  • Stück, B., Old, L. J., and Boyse, E. A., 1964, Antigenic conversion of established leukemias by an unrelated leukaemogenic virus, Nature (London) 202:1016.

    Article  Google Scholar 

  • Stutman, O., 1975, Immunodepression and malignancy, Adv. Cancer Res. 22:261.

    Article  PubMed  CAS  Google Scholar 

  • Tai, A., Burton, R. C., and Warner, N. L., 1980, Differential natural killer cell reactivity against T cell lymphomas by cells from normal or stimulated mice, J. Immunol. 124:1705.

    PubMed  CAS  Google Scholar 

  • Talmadge, J. E., Mayers, K. M., Prieur, D. J., and Starkey, J. R. 1980, Role of NK cells in tumour growth and metastasis in beige mice, Nature (London) 284:622.

    Article  CAS  Google Scholar 

  • Tevethia, S. S., Zarling, J. M., and Flax, M. H., 1976, Macrophages and the destruction of syngeneic virus-induced tumors, in: Immunology of the Macrophage (D. S. Nelson, ed.), pp. 509–533, Academic Press, New York.

    Google Scholar 

  • Till, J. E., 1981, Cellular diversity in the blood-forming system, Am. Sci. 69:522–527.

    PubMed  CAS  Google Scholar 

  • Tooze, J., 1973, The Molecular Biology of Tumor Viruses, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

    Google Scholar 

  • Treves, A. J., 1978, In vitro induction of cell-mediated immunity against tumor cells by antigen-fed macrophages, Immunol. Rev. 40:205.

    Article  PubMed  CAS  Google Scholar 

  • Tung, J.-S., and Fleissner, E., 1980, Amplified env and gag products on AKR cells: Origin from different leukemia virus genomes, J. Exp. Med. 151:975.

    Article  PubMed  CAS  Google Scholar 

  • van Ewijk, W., Soest, P. L. v., and Engh, G. J. van der, 1981, Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200, J. Immunol. 127:2594.

    PubMed  Google Scholar 

  • van Fournier, D., Weber, E., Hoeffken, W., Bauer, M., Kubli, F., and Barth, V., 1980, Growth rate of 147 mammary carcinomas, Cancer 45:2198.

    Article  Google Scholar 

  • Williams, A. H., Taylor, C. R., Higgins, G. R., Quinn, J. J., Schneider, B. K., Swanson, V., Parker, J. W., Pattengale, P. K., Chandor, S. B., Powars, D., Lincoln, T. L., Tindle, B. H., and Lukes, R. J., 1978, Childhood lymphoma-leukemia, Cancer 42:171.

    Article  PubMed  CAS  Google Scholar 

  • Wright, P. W., and Loop, S. M., 1979, Amplification of the proliferative response to alloantigen by a factor present in an extract of syngeneic thymic lymphoid cells: Demonstration of optimal conditions and target cell for factor activity, J. Immunol. 122:2435.

    PubMed  CAS  Google Scholar 

  • Yarkoni, E., and Rapp, H. J., 1980, Influence of surfactant concentration on the antitumor activity of emulsified components of mycobacteria, Cancer Res. 40:975.

    PubMed  CAS  Google Scholar 

  • Zaleski, M., and Klein, J., 1978, Genetic control of the immune response to Thy-1 antigens, Immunol. Rev. 38:120.

    Article  PubMed  CAS  Google Scholar 

  • Zbar, B., Canti, G., Rapp, H. J., Ashley, M. P., Sukumar, S., and Bast, R. C., Jr., 1980, Immu-noprophylaxis of syngeneic methylcholanthrene-induced murine sarcomas with Bacillus Calmette-Guérin and tumor cells, Cancer Res. 40:1036.

    PubMed  CAS  Google Scholar 

  • Zöller, M., and Matzku, S., 1980, Characterization of natural cytotoxicity in vitro in a spontaneous rat tumor model, J. Immunol. 124:1683.

    PubMed  Google Scholar 

  • Zubrod, C. G., 1978, Selective toxicity of anticancer drugs—Presidential address, Cancer Res. 38:4377.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Reif, A.E. (1983). Immunopathology of Malignant Disease in Mice Leukemias and Lymphomas, Stalking-Horses for Human Counterparts. In: Rose, N.R., Siegel, B.V. (eds) Immunopathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9275-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9275-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9277-8

  • Online ISBN: 978-1-4615-9275-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics