Skip to main content
SpringerLink
Log in

Immunopathology of Malignant Disease in Humans

  • Chapter
Immunopathology

  • 37 Accesses

Abstract

Most of the knowledge of the immune response to malignant tumors is based on manipulations of induced and spontaneous tumors in experimental animals. It has only been within the last two decades that the presence of tumor antigens and the hosťs ability to respond to them have been clearly demonstrated in humans. Knowledge of the significance and variability of this response is in its infancy. This probably accounts for the disappointing results of premature attempts to treat neoplasms by immunological methods.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abdou, N. I., and Abdou, N. L., 1972, Anti-immunoglobulins in multiple myeloma, Clin. Exp. Immunol. 11:57.

    PubMed  CAS  Google Scholar 

  • Abelev, G. I., Assecritova, I. V., Kraevsky, N. A., Perova, S. D., and Perevodchikova, N. I., 1967, Embryonal serum α-globulin in cancer patients: Diagnostic value, Int. J. Cancer 2:551.

    Article  PubMed  CAS  Google Scholar 

  • Adams, D. O., and Snyderman, R., 1979, Do macrophages destroy nascent tumors? J. Natl. Cancer Inst. 62:1341.

    PubMed  CAS  Google Scholar 

  • Alexander, P., 1974, Escape from immune destruction by the host through shedding of surface antigens: Is this a characteristic shared by malignant and embryonic cells?, Cancer Res. 34:2077.

    PubMed  CAS  Google Scholar 

  • Alexander, P., Eccles, S. A., and Gauci, C. L. L., 1976, The significance of macrophages in human and experimental tumors, Ann. N.Y. Acad. Sci. 276:124.

    Article  PubMed  CAS  Google Scholar 

  • Allen, E. M., and Moore, V. L., 1979, Suppression of phytohemagglutinin and lipopolysaccharide responses in mouse spleen cells by Bacillus Calmette-Guérin, J. Reticuloendothelial Soc. 26:349.

    CAS  Google Scholar 

  • Allison, A. C., Monga, J. N., and Hammond, V., 1974, Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice, Nature (London) 252:746.

    Article  CAS  Google Scholar 

  • Alpert, M. E., Uriel, J., and deNechaud, B., 1968, Alpha fetoglobulin in the diagnosis of human hepatoma, N. Engl. J. Med. 278:984.

    Article  PubMed  CAS  Google Scholar 

  • Andersen, V., Bjerrum, O., Bendixen, G., SchiÞdt, T., and Dissing, I., 1970, Effect of autologous mammary tumor extracts on human leukocyte migration in vitro, Int. J. Cancer 5:357.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Price, M. R., and Robins, R. A., 1972, Blocking of lymphoctye-mediated cytotoxicity for rat hepatoma cells by tumor-specific antigen-antibody complexes, Nature New Biol. 238:185.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Price, M. R., and Robins, R. A., 1973, Inhibition of hepatoma-immune lymph-node cell cytotoxicity by tumor-bearer serum, and solubilized hepatoma antigen, Int. J. Cancer 11:527.

    Article  PubMed  CAS  Google Scholar 

  • Bansal, S. C., and Sjögren, H. O., 1973, Effects of BCG on various facets of the immune response against polyoma tumors in rats, Int. J. Cancer 11:162.

    Article  PubMed  CAS  Google Scholar 

  • Bansal, S. C., Bansal, B. R., and Boland, J. P., 1976, Blocking and unblocking serum factors in neoplasia, Curr. Top. Microbiol. Immunol. 75:45.

    PubMed  CAS  Google Scholar 

  • Bartholomaeus, W. N., Bray, A. E., Papadimitriou, J. M., and Keast, D., 1974, Immune response to a transplantable malignant melanoma in mice, J. Natl. Cancer Inst. 53:1065.

    PubMed  CAS  Google Scholar 

  • Bartlett, G. L., 1972, Effect of host immunity on the antigenic strength of primary tumors, J. Natl. Cancer Inst. 49:493.

    PubMed  CAS  Google Scholar 

  • Bast, R. C., Jr., Zbar, B., Borsos, T., and Rapp, H. J., 1974, BCG and cancer, N. Engl. J. Med. 290:1413; 1458.

    Article  PubMed  Google Scholar 

  • Berg, J. W., 1956, Sinus histiocytosis: A fallacious measure of host resistance to cancer, Cancer 9:935.

    Article  PubMed  CAS  Google Scholar 

  • Black, M. M., and Speer, F. D., 1958, Sinus histiocytosis of lymph nodes in cancer, Surg. Gynecol. Obstet. 106:163.

    PubMed  CAS  Google Scholar 

  • Black, M. M., Kerpe, S., and Speer, F. D., 1953, Lymph node structure in patients with cancer of the breast, Am. J. Pathol. 29:505.

    PubMed  CAS  Google Scholar 

  • Black, M. M., Opler, S. R., and Speer, F. D., 1955, Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes, Surg. Gynecol. Obstet. 100:543.

    PubMed  CAS  Google Scholar 

  • Black, M. M., Leis, H. P., Shore, B., and Zachrau, R. E., 1974, Cellular hypersensitivity to breast cancer: Assessment by a leukocyte migration procedure, Cancer 33:952.

    Article  PubMed  CAS  Google Scholar 

  • Boetcher, D. A., and Leonard, E. J., 1974, Abnormal monocyte chemotactic response in cancer patients, J. Natl. Cancer Inst. 52:1091.

    PubMed  CAS  Google Scholar 

  • Bornstein, R. S., Mastrangelo, M. J., Sulit, H., Chee, D., Yarbro, J. W., Prehn, L. M., and Prehn, R. T., 1973, Immunotherapy of melanoma with intralesional BCG, Natl. Cancer Inst. Monogr. 39:213.

    PubMed  CAS  Google Scholar 

  • Boyse, E. A., Old, L. J., and Oetigen, H. F., 1976, Human tumor immunology, in: Textbook of Immunopathology, Vol. II (P. A. Miescher and H. J. MÃŒller-Eberhard, eds.), pp. 1080–1100, Grune & Stratton, New York.

    Google Scholar 

  • Broder, S., and Waldmann, T. A., 1978, The suppressor-cell network in cancer, N. Engl. J. Med. 299:1281; 1335.

    Article  PubMed  CAS  Google Scholar 

  • Broder, S., Muul, L., and Waldmann, T. A., 1978, Suppressor cells in neoplastic disease, J. Natl. Cancer Inst. 61:5.

    PubMed  CAS  Google Scholar 

  • Bucana, C., Hoyer, L. C., Hobbs, B., Breesman, S., McDaniel, M., and Hanna, M. G., Jr., 1976, Morphological evidence for the translocation of lysosomal organelles from cytotoxic macrophages into the cytoplasm of tumor target cells, Cancer Res. 36:4444.

    PubMed  CAS  Google Scholar 

  • Burnet, F. M., 1971, Immunological surveillance in neoplasia, Transplant. Rev. 7:3.

    PubMed  CAS  Google Scholar 

  • Cantarow, W. D., Cheung, H. T., and Sundharadas, G., 1978, Modulation of spreading, adhesion and migration of peritoneal macrophages by a low molecular weight factor extracted from mouse tumors, J. Reticuloendothelial Soc. 24:657.

    CAS  Google Scholar 

  • Cantor, H., and Gershon, R. K., 1979, Immunological circuits: Cellular composition, Fed. Proc. 38:2058.

    PubMed  CAS  Google Scholar 

  • Carrel, S., Accolla, R. S., Carmgnola, A. L., and Mack, J. P., 1980, Common human melanoma-associated antigen(s) detected by monoclonal antibodies, Cancer Res. 40:2523.

    PubMed  CAS  Google Scholar 

  • Cheung, H.T., Cantarow, W. D., and Sundharadas, G., 1979, Tumoricidal activity of macrophages induced by lipopolysaccharide and its inhibition by a low molecular weight factor extracted from tumors, J. Reticuloendothelial Soc. 26:21.

    CAS  Google Scholar 

  • Chu, E. H. Y., StjernswÀrd, J., Clifford, P., and Klein, G., 1967, Reactivity of human lymphocytes against autochthonous and allogeneic normal and tumor cells in vitro, J. Natl. Cancer Inst. 39:595.

    PubMed  CAS  Google Scholar 

  • Ciembroniewicz, J., and Kolar, O., 1969, Tissue culture study of glioblastoma cells with addition of autologous lymphocytes, Acta Cytol. 13:42.

    PubMed  CAS  Google Scholar 

  • Clark, W. H., Jr., Mastrangelo, M. J., Ainsworth, A. M., Berd, D., Bellet, R. E., and Bernardino, E. A., 1977, Current concepts of the biology of human cutaneous malignant melanoma, Adv. Cancer Res. 24:267.

    Article  PubMed  Google Scholar 

  • Cohen, A. M., 1973, Host immunity to growing sarcomas: Tumor-specific serum inhibition of tumor-specific cellular immunity, Cancer 31:81.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, S., Fisher, B., Yoshida, T., and Bettigole, R. E., 1974, Serum migration-inhibitory activity in patients with lymphoproliferative diseases, N. Engl. J. Med. 290:882.

    Article  PubMed  CAS  Google Scholar 

  • Dippold, W. D., Lloyd, K. O., Li, L. T. C., Ikeda, H., Oettgen, H. F., and Old, L. J., 1980, Cell surface antigens of human malignant melanoma: Definition of six new antigenic systems with monoclonal antibodies, Proc. Natl. Acad. Sci. USA 77:6114.

    Article  PubMed  CAS  Google Scholar 

  • Eccles, S. A., and Alexander, P., 1974, Sequestration of macrophages in growing tumors and its effects on the immunological capacity of the host, Br. J. Cancer 30:42.

    Article  PubMed  CAS  Google Scholar 

  • Edynak, E. M., Old, L. J., Vrana, M., and Lardis, M., 1970, A fetal antigen in human tumors detected by an antibody in the serum of cancer patients, Proc. Am. Assoc. Cancer Res. 11:22.

    Google Scholar 

  • Eilber, F. R., and Morton, D. L., 1970, Immunologic studies of human sarcomas: Additional evidence suggesting an associated sarcoma virus, Cancer 26:588.

    Article  PubMed  CAS  Google Scholar 

  • Fakhri, O., McLaughlin, H., and Hobbs, J. R., 1973, 7S anti-tumor antibodies and activated Fc in macrophage tumor cell interaction, Eur. J. Cancer 9:19.

    PubMed  CAS  Google Scholar 

  • Fass, L., Herberman, R. B., and Ziegler, J., 1970a, Delayed cutaneous hypersensitivity reactions to autologous extracts of Burkitt-lymphoma cells, N. Engl. J. Med. 282:776.

    Article  PubMed  CAS  Google Scholar 

  • Fass, L., Herberman, R. B., Ziegler, J. L., and Kiryabwire, J. W. M., 1970b, Cutaneous hypersensitivity reactions to autologous extracts of malignant melanoma cells, Lancet 1:116.

    Article  PubMed  CAS  Google Scholar 

  • Fidler, I. J., 1973, In vitro sutdies of cellular-mediated immunostimulation of tumor growth, J. Natl. Cancer Inst. 50:1307.

    PubMed  CAS  Google Scholar 

  • Fidler, I. J., Budmen, M. B., and Hanna, M. G., Jr., 1976, Characterization of in vitro reactivity by BCG-treated guinea pigs to syngeneic line-10 hepatocarcinoma, Cancer Immunol. Immunother. 1:179.

    Article  Google Scholar 

  • Fisher, B., Saffer, E. A., and Fisher, E. R., 1974, Studies concerning the regional lymph nodes in cancer. VI. Thymidine uptake by cells from nodes of breast cancer patients relative to axillary location and histopathologic discriminants, Cancer 33:271.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, E. R., and Fisher, B., 1972, Local lymphoid response as an index of tumor immunity, Arch. Pathol. 94:137.

    PubMed  CAS  Google Scholar 

  • Fisher, E. R., Saffer, E., and Fisher, B., 1973, Studies concerning the regional lymph node in cancer. VI. Correlation of lymphocyte transformation of regional node cells and some histopathologic discriminants, Cancer 32:104.

    Article  PubMed  CAS  Google Scholar 

  • Foley, E. J., 1953, Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin, Cancer Res. 13:835.

    PubMed  CAS  Google Scholar 

  • Fridman, W. H., and Kourilsky, F. M., 1969, Stimulation of lymphocytes by autologous leukaemia cells in acute leukaemia, Nature (London) 224:227.

    Article  Google Scholar 

  • Fukuda, M., Wanebo, H. J., Tsuei, L., and Sarkar, N. H., 1979, Leukocyte migration inhibition response to various antigen preparations of autologous and homologous breast cancer in patients with primary breast cancer, J. Natl. Cancer Inst. 63:1161.

    PubMed  CAS  Google Scholar 

  • Giraldo, G., Beth, E., Hirshaut, Y., Aoki, T., Old, L. J., Boyse, E. A., and Chopra, H. C., 1971, Human sarcomas in culture: Foci of altered cells and a common antigen; induction of foci and antigen in human fibroblast cultures by filtrates, J. Exp. Med. 133:454.

    Article  PubMed  CAS  Google Scholar 

  • Gold, P., 1967, Circulating antibodies against carcinoembryonic antigens of the human digestive system, Cancer 20:1663.

    Article  Google Scholar 

  • Gold, P., and Freedman, S. O., 1965a, Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques, J. Exp. Med. 121:439.

    Article  PubMed  CAS  Google Scholar 

  • Gold, P., and Freedman, S. O., 1965b, Specific carcinoembryonic antigens of the human digestive system, J. Exp. Med. 122:467.

    Article  PubMed  CAS  Google Scholar 

  • Gold, P., Gold, M., and Freedman, S. O., 1968, Cellular location of carcinoembryonic antigens of the human digestive system, Cancer Res. 28:1331.

    PubMed  CAS  Google Scholar 

  • Good, R. A., and Finstad, J., 1969, Essential relationship between the lymphoid system, immunity and malignancy, Natl. Cancer Inst. Monogr. 31:41.

    PubMed  CAS  Google Scholar 

  • Goodwin, J. S., Messner, R. P., Bankhurst, A. D., Peake, G. T., Saiki, J. H., and Williams, R. C., Jr., 1977, Prostaglandin-producing suppressor cells in Hodgkin’s disease, N. Engl. J. Med. 297:963.

    Article  PubMed  CAS  Google Scholar 

  • Gross, L., 1943, Intradermal immunization of C3H mice against a sarcoma that originated in an animal of the same line, Cancer Res. 3:326.

    Google Scholar 

  • Gross, L., 1945, The specificity of acquired tumor immunity, J. Immunol. 50:91.

    Google Scholar 

  • Grosser, N., and Thomson, D. M. P., 1976, Tube leukocyte (monocyte) adherence inhibition assay for the detection of anti-tumor immunity. III. “Blockade” of monocyte reactivity by excess free antigen and immune complexes in advanced cancer patients, Int. J. Cancer 18:58.

    Article  PubMed  CAS  Google Scholar 

  • Haller, O., Hansson, M., Kiessling, R., and Wigzell, H., 1977, Role of non-conventional natural killer cells in resistance against syngeneic tumor cells in vivo, Nature (London) 270:609.

    Article  CAS  Google Scholar 

  • Hanna, M. G., Jr., Zbar, B., and Rapp, H. J., 1972a, Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. I. Tumor growth and metastases, J. Natl. Cancer Inst. 48:1441.

    PubMed  Google Scholar 

  • Hanna, M. G., Jr., Zbar, B., and Rapp, H. J., 1972b, Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. II. Comparative effects of vaccinia virus, oxazolone and turpentine, J. Natl. Cancer Inst. 48:1697.

    PubMed  CAS  Google Scholar 

  • Haskill, J. S., Yamamura, Y., Radov, L., and Parthenais, E., 1976, Discussion paper: Are peripheral and in situ tumor immunity related?, Ann. N.Y. Acad. Sci. 276:373.

    Article  PubMed  CAS  Google Scholar 

  • Hellström, I., Hellström, K. E., Sjögren, H. O., and Warner, G. A., 1971, Demonstration of cell-mediated immunity to human neoplasms of various histological types, Int. J. Cancer 7:1.

    Article  PubMed  Google Scholar 

  • Hellström, K. E., and Hellström, I., 1974, Lymphocyte mediated cytotoxicity and blocking serum activity to tumor antigens, Adv. Immunol. 18:209.

    Article  PubMed  Google Scholar 

  • Henney, C. S., Tracey, D., Durdik, J. M., and Klimpel, G., 1978, Natural killer cells, Am. J. Pathol. 93:459.

    PubMed  CAS  Google Scholar 

  • Hibbs, J. B., Jr., Taintor, R. R., Chapman, H. A., Jr., and Weinberg, J. B., 1977, Macrophage tumor killing: Influence of the local environment, Science 197:279.

    Article  PubMed  Google Scholar 

  • Hibbs, J. B., Jr., Chapman, H. A., Jr., and Weinberg, J. B., 1978, The macrophage as an antineoplastic surveillance cell: Biological perspectives, J. Reticuloendothelial Soc. 24:549.

    CAS  Google Scholar 

  • Himmelweit, F. (ed.), 1957, The Collected Papers of Paul Ehrlich, Vol. II, pp. 550–562, Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Hollinshead, A., Glew, D., Bunnag, B., Gold, P., and Herberman, R., 1970, Skin-reactive soluble antigen from intestinal cancer-cell-membranes and relationship to carcinoembryonic antigens, Lancet 1:1191.

    Article  PubMed  CAS  Google Scholar 

  • Hoover, R., and Fraumeni, J. F., Jr., 1973, Risk of cancer in renal-transplant recipients, Lancet 2:55.

    Article  PubMed  CAS  Google Scholar 

  • Hughes, L. E., and Lytton, B., 1964, Antigenic properties of human tumors: Delayed cutaneous hypersensitivity reactions, Br. Med. J. 1:209.

    Article  PubMed  CAS  Google Scholar 

  • Ilfeld, D., Carnaud, C., Cohen, I. R., and Trainin, N., 1973, In vitro cytotoxicity and in vivo tumor enhancement induced by mouse spleen cells autosensitized in vitro, Int. J. Cancer 12:213.

    Article  PubMed  CAS  Google Scholar 

  • Ioachim, H. L., 1976, The stromal reaction of tumors: An expression of immune surveillance, J. Natl. Cancer Inst. 57:465.

    PubMed  CAS  Google Scholar 

  • Jehn, U. W., Nathanson, L., Schwartz, R. S., and Skinner, M., 1970, In vitro lymphocyte stimulation by a soluble antigen from malignant melanoma, N. Engl. J. Med. 283:329.

    Article  PubMed  CAS  Google Scholar 

  • Kall, M. A., and Hellström, I., 1975, Specific stimulatory and cytotoxic effects of lymphoctyes sensitized in vitro to either alloantigens or tumor antigens, J. Immunol. 114:1083.

    PubMed  CAS  Google Scholar 

  • Klein, G., Geering, G., Old, L. J., Henle, G., Henle, W., and Clifford, P., 1970, Comparison of the anti-EBV titer and the EBV-associated membrane reactive and precipitating antibody levels in the sera of Burkitt lymphoma and nasopharyngeal carcinoma patients and controls, Int. J. Cancer 5:185.

    Article  PubMed  CAS  Google Scholar 

  • Krupey, J., Gold, P., and Freedman, S. O., 1968, Physicochemical studies of the carcinoembryonic antigens of the human digestive system, J. Exp. Med. 128:387.

    Article  PubMed  CAS  Google Scholar 

  • Laroye, G. J., 1975, Immunological surveillance against cancer: Critique of an established hypothesis, Med. Hypothesis 1:43.

    Article  CAS  Google Scholar 

  • Levy, N. L., Mahaley, M. S., Jr., and Day, E. D., 1972, Serum-mediated blocking of cell-mediated anti-tumor immunity in a melanoma patient: Association with BCG immunotherapy and clinical deterioration, Int. J. Cancer 10:244.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, G. P., 1977, Prostaglandins in inflammation, J. Reticuloendothelial Soc. 22:389.

    CAS  Google Scholar 

  • Lewis, M. G., Ikonopisov, R. L., Nairn, R. C., Phillips, T. M., Fairley, G. H., Bodenham, D. C., and Alexander, P., 1969, Tumor-specific antibodies in human malignant melanoma and their relationship to the extent of the disease, Br. Med. J. 3:547.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, M. G., Hartman, D., and Jerry, L. M., 1976, Antibodies and anti-antibodies in human malignancy: An expression of deranged immune regulation, Ann. N.Y. Acad. Sci. 276:316.

    Article  PubMed  CAS  Google Scholar 

  • Lindstrom, F. D., and Williams, R. C., Jr., 1975, Serum anti-immunoglobulins in multiple myeloma and benign monoclonal gammopathy, Clin. Immunol. Immunopathol. 3:503.

    Article  PubMed  CAS  Google Scholar 

  • Linscott, W. D., 1970, Effect of cell surface antigen density on immunological enhancement, Nature (London) 228:824.

    Article  CAS  Google Scholar 

  • Mansell, P. W. A., DiLuzio, N. R., McNamee, R., Rowden, G., and Proctor, J. W., 1978, Recognition factors and nonspecific macrophage activation in the treatment of neoplastic disease, Ann. N.Y. Acad. Sci. 277:20.

    Article  Google Scholar 

  • Mathé, G., Florentin, I., Olsson, L., Bruley-Rosset, M., Schulz, J., Kiger, N., Orbach-Arbouys, S., Schwarzenberg, L., Pouillart, P., and deVassal, F., 1978, Pharmacologie factors and manipulation of immunity systemic adjuvants in cancer therapy, Cancer Treatment Rep. 62:1613.

    Google Scholar 

  • McKhann, C. F., 1969, Primary malignancy in patients undergoing immunosuppression for renal transplantation, Transplantation 8:209.

    Article  PubMed  CAS  Google Scholar 

  • Medina, D., and Heppner, G., 1973, Cell-mediated “immunostimulation” induced by mammary tumor virus-free BALB/c mammary tumors, Nature (London) 242:329.

    Article  CAS  Google Scholar 

  • Meltzer, M. S., and Stevenson, M. M., 1978, Macrophage function in tumor-bearing mice: Dissociation of phagocytic and chemotactic responsiveness, Cell Immunol. 35:99.

    Article  PubMed  CAS  Google Scholar 

  • Meltzer, M. S., Ruco, L. P., Boraschi, D., and Nacy, C. A., 1979, Macrophage activation for tumor cytotoxicity: Analysis of intermediary reactions, J. Reticuloendothelial Soc. 26:403.

    CAS  Google Scholar 

  • Milstein, C., 1981, Monoclonal antibodies from hybrid melanomas, Proc. Royal Soc. London B211:393.

    Article  Google Scholar 

  • Mitsuoka, A., Morikawa, S., Baba, M., and Harada, T., 1979, Cyclophosphamide eliminates suppressor T cells in age-associated central regulation of delayed hypersensitivity in mice, J. Exp. Med. 149:1018.

    Article  PubMed  CAS  Google Scholar 

  • Möller, G., and Möller, E., 1976, The concept of immunological surveillance against neoplasia, Transplant. Rev. 28:3.

    PubMed  Google Scholar 

  • Moore, R. D., Sorenson, G. D., and Schoenberg, M. D., 1959, Progressive cellular alterations of lymph nodes, Arch. Pathol. 67:274.

    CAS  Google Scholar 

  • Moore, R. D., Chapnick, R., and Schoenberg, M. D., 1960, Lymph nodes associated with carcinoma of the breast, Cancer 13:545.

    Article  PubMed  CAS  Google Scholar 

  • Morton, D. L., and Malmgren, R. A., 1968, Human osteosarcomas: Immunologic evidence suggesting an associated infectious agent, Science 162:1279.

    Article  PubMed  CAS  Google Scholar 

  • Morton, D. L., Mamlgren, R. A., Holmes, E. C., and Ketcham, A., 1968, Demonstration of antibodies against human malignant melanoma by immunofluorescence, Surgery 64:233.

    PubMed  CAS  Google Scholar 

  • Morton, D. L., Malmbren, R. A., Hall, W. T., and Schidlovsky, G., 1969, Immunologic and virus studies with human sarcomas, Surgery 66:152.

    PubMed  CAS  Google Scholar 

  • Morton, J. I., Siegel, B. V., and Moore, R. D., 1978, Autoimmunity and tumor resistance: 3-Methylcholanthrene tumorigenesis in New Zealand Black mice, Am. J. Pathol. 93:469.

    PubMed  CAS  Google Scholar 

  • Murphy, J. B., Nakahara, W., and Sturm, E., 1921, Studies on lymphoid activity. V. Relation between the time and extent of lymphoid stimulation induced by physical agents and the degree of resistance to cancer in mice, J. Exp. Med. 33:423.

    Article  PubMed  CAS  Google Scholar 

  • Norman, S. J., and Sorkin, E., 1977, Inhibition of macrophage Chemotaxis by neoplastic and other rapidly proliferating cells in vitro. Cancer Res. 37:705.

    Google Scholar 

  • Occhino, J. C., Glasgow, A. H., Cooperband, S. R., Mannick, J. A., and Schmid, K., 1973, Isolation of an immunosuppressive peptide fraction from human plasma, J. Immunol. 110:685.

    PubMed  CAS  Google Scholar 

  • Oettgen, H. F., 1977, Immunotherapy of cancer, N. Engl. J. Med. 297:484.

    Article  PubMed  CAS  Google Scholar 

  • Oettgen, H. F., Aoki, T., Old, L. J., Boyse, E. A., DeHarven, E., and Mills, G. M., 1968, Suspension culture of a pigment-producing cell line derived from a human malignant melanoma, J. Natl. Cancer Inst. 41:827.

    PubMed  CAS  Google Scholar 

  • Old, L. J., 1981, The search for specificity—G. H. A. Clowes Memorial Lecture, Cancer Res. 41:361.

    PubMed  CAS  Google Scholar 

  • Old, L. J., Boyse, E. A., Geering, G., and Oettgen, H. F., 1968, Serologic approaches to the study of cancer in animals and in man, Cancer Res. 28:1288.

    PubMed  CAS  Google Scholar 

  • Outzen, H. C., Custer, R. P., Eaton, G. J., and Prehn, R. T., 1975, Spontaneous and induced tumor incidence in germfree “nude” mice, J.Reticuloendothelial Soc. 17:1.

    CAS  Google Scholar 

  • Paglieroni, T., and MacKenzie, M. R., 1977, Studies on the pathogenesis of an immune defect in multiple myeloma, J. Clin. Invest. 59:1120.

    Article  PubMed  CAS  Google Scholar 

  • Perry, L. L., Benacerraf, B., McCluskey, R. T., and Greene, M. I., 1978, Enhanced syngeneic tumor destruction by in vivo inhibition of suppressor T cells using anti-I-J alloantiserum, Am. J. Pathol. 92:491.

    PubMed  CAS  Google Scholar 

  • Piessens, W. F., Churchill, W. H., Jr., and David, J. R., 1975, Macrophages activated in vitro with lymphocyte mediators kill neoplastic but not normal cells, J. Immunol. 114:293.

    PubMed  CAS  Google Scholar 

  • Pollard, M., Kajima, M., and Lorans, G., 1968, Tissue changes in germ-free rats with primary tumors, J. Reticuloendothelial Soc. 5:147.

    CAS  Google Scholar 

  • Prehn, R. T., 1971, Perspectives on oncogenesis: Does immunity stimulate or inhibit neoplasia?, J. Reticuloendothelial Soc. 10:1.

    CAS  Google Scholar 

  • Prehn, R. T., 1972, The immune reaction as a stimulator of tumor growth, Science 176:170.

    Article  PubMed  CAS  Google Scholar 

  • Prehn, R. T., 1976, Do tumors grow because of the immune response of the host?, Transplant. Rev. 28:34.

    PubMed  CAS  Google Scholar 

  • Prehn, R. T., 1977, Immunostimulation of the lympho-dependent phase of neoplastic growth, J. Natl. Cancer Inst. 59:1043.

    PubMed  CAS  Google Scholar 

  • Prehn, R. T., and Lappé, M. A., 1971, An immunostimulation theory of tumor development, Transplant. Rev. 7:26.

    PubMed  CAS  Google Scholar 

  • Prehn, R. T., and Main, J. M., 1957, Immunity to methylcholanthrene-induced sarcoma, J. Natl. Cancer Inst. 18:769.

    PubMed  CAS  Google Scholar 

  • Purves, L. R., Bersohn, I., and Geddes, E. W., 1970, Serum alpha-fetoprotein and primary cancer of the liver in man, Cancer 25:1261.

    Article  PubMed  CAS  Google Scholar 

  • Reinisch, C. L., Andrew, S. L., and Schlossman, S. F., 1977, Suppressor cell regulation of immune response to tumors: Abrogation by adult thymectomy, Proc. Natl. Acad. Sci. USA 74:2989.

    Article  PubMed  CAS  Google Scholar 

  • Rhodes, J., Bishop, M., and Benfield, J., 1979, Tumor surveillance: How tumors may resist macrophage-mediated host defense, Science 203:179.

    Article  PubMed  CAS  Google Scholar 

  • Robbins, S. L., and Cotran, R. S., 1979, Pathologic Basis of Disease, pp. 162–164, Saunders, Philadelphia.

    Google Scholar 

  • Röllinghoff, M., Starzinski-Powitz, A., Pfizenmaier, K., and Wagner, H., 1977, Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T-lympho-cytes, J. Exp. Med. 145:455.

    Article  PubMed  Google Scholar 

  • Russel, B. R., 1908, The nature of resistance to the inoculation of cancer, Imperial Cancer Res. Fund 3:341.

    Google Scholar 

  • Rygaard, J., and Povlsen, C. O., 1974, The mouse mutant nude does not develop spontaneous tumors, Acta Pathol. Microbiol. Scand. Sect. B 82:99.

    CAS  Google Scholar 

  • Schlesinger, M., 1976, Immune responses to tumors and their antigens: Cellular and humoral mechanisms. Introductory remarks, Ann. N.Y. Acad. Sci. 276:276.

    Article  Google Scholar 

  • Schultz, R. M., Papamatheakis, J. D., and Chirigos, M. A., 1977, Interferon: An inducer of macrophage activation by polyanions, Science 197:674.

    Article  PubMed  CAS  Google Scholar 

  • Schultz, R. M., Pavlidis, N. A., Chirigos, M. A., and Weiss, J. F., 1978a, Effects of whole body x-irradiation and cyclophosphamide treatment on induction of macrophage tumoricidal function in mice, Cell. Immunol. 38:302.

    Article  PubMed  CAS  Google Scholar 

  • Schultz, R. M., Pavlidis, N. A., Stylos, W. A., and Chirigos, M. A., 1978b, Regulation of macrophage tumoricidal function: A role for prostaglandins of the E series, Science 202:320.

    CAS  Google Scholar 

  • Sjögren, H. O., Hellström, I., Bansal, S. C., and Hellström, K. E., 1971, Suggestive evidence that the ‘‘blocking antibodies” of tumor-bearing individuals may be antigen-antibody complexes, Proc. Natl. Acad. Sci. USA 68:1372.

    Article  PubMed  Google Scholar 

  • Snyderman, R., and Pike, M. C., 1976, An inhibitor of macrophage Chemotaxis produced by neoplasms, Science 192:370.

    Article  PubMed  CAS  Google Scholar 

  • Snyderman, R., and Pike, M. C., 1977, Macrophage migratory dysfunction in cancer, Am. J. Pathol. 88:727.

    PubMed  CAS  Google Scholar 

  • Southam, C.M., Brunschwig, A., Levin, A. G., and Dizon, Q. S., 1966, Effect of leukocytes on transplantability of human cancer, Cancer 19:1743.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, T. H. M., 1969, The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors, Cancer 23:1368.

    Article  PubMed  CAS  Google Scholar 

  • Stutman, O., 1974, Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice, Science 183:534.

    Article  PubMed  CAS  Google Scholar 

  • Stutman, O., 1975, Immunodepression and malignancy, Adv. Cancer Res. 22:261.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, L., 1961, Discussion of reactions to homologous tissue antigens in relation to hypersensitivity, in: Cellular and Humoral Aspects of Hypersensitivity States (H. S. Lawrence, ed.), pp. 529–532, Hoeber, New York.

    Google Scholar 

  • Thomson, D. M. P., Krupey, J., Freedman, S. O., and Gold, P., 1969, The radioimmunoassay of circulating carcinoembryonic antigens of the human digestive system, Proc. Natl. Acad. Sci. USA 64:161.

    Article  PubMed  CAS  Google Scholar 

  • Turk, J. L., Parker, D., and Pulter, L. W., 1972, Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide, Immunology 23:493.

    PubMed  CAS  Google Scholar 

  • Umiel, T., and Trainin, N., 1974, Immunological enhancement of tumor growth by syngeneic thymus-derived lymphocytes, Transplantation 18:244.

    Article  PubMed  CAS  Google Scholar 

  • Vandeputte, M., Eyssen, H., Sobis, H., and De Somer, P., 1974, Induction of polyoma tumors in athymic nude mice, Int. J. Cancer 14:445.

    Article  PubMed  CAS  Google Scholar 

  • Vorbrodt, A., Hliniak, A., KrÅŒyzowska-Gruca, St., and Gruca, St., 1972, Ultrastructural studies on the behavior of macrophages in the course of X-ray therapy of human skin cancer, Acta Histochem. 43:270.

    PubMed  CAS  Google Scholar 

  • Wood, G. W., and Gollahon, K. A., 1977, Detection and quantitation of macrophage infiltration into primary human tumors with the use of cell-surface markers, J. Natl. Cancer Inst. 59:1081.

    PubMed  CAS  Google Scholar 

  • Wood, W. C., and Morton, D. L., 1970, Microcytotoxicity test: Detection in sarcoma patients of antibody cytotoxic to human sarcoma cells, Science 170:1318.

    Article  PubMed  CAS  Google Scholar 

  • Yu, A., Watts, H., Jaffe, N., and Parkman, R., 1977, Concomitant presence of tumor-specific cytotoxic and inhibitor lymphocytes in patients with osteogenic sarcoma, N. Engl. J. Med. 297:121.

    Article  PubMed  CAS  Google Scholar 

  • Zembala, M., Mytar, B., Popiela, T., and Asherson, G. L., 1977, Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: The role of suppressor cells, Int. J. Cancer 19:605.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Oregon Health Sciences Center, Portland, Oregon, 97201, USA

    Richard D. Moore

Authors
  1. Richard D. Moore
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Johns Hopkins University, Baltimore, Maryland, USA

    Noel R. Rose

  2. Oregon Health Sciences University, Portland, Oregon, USA

    Benjamin V. Siegel

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Moore, R.D. (1983). Immunopathology of Malignant Disease in Humans. In: Rose, N.R., Siegel, B.V. (eds) Immunopathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9275-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9275-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9277-8

  • Online ISBN: 978-1-4615-9275-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation