Abstract
Osmotic agents, such as urea18 and mannitol,52 have been used for over 20 years to treat increased intracranial pressure (ICP). The usefulness of the currently used agent, mannitol, had been limited by the fluid and electrolyte disturbances that occurred with the recommended dosages of 2–4 g/kg. To overcome these limitations, lower mannitol dosages of 0.25–1.5 g/kg have been tested in patients and found to be effective in temporarily controlling ICP.22, 26
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Rosenberg, G.A., Kyner, W.T. (1983). Effect of Mannitol-Induced Hyperosmolarity on Transport between Brain Interstitial Fluid and Cerebrospinal Fluid. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_49
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