Abstract
In the preantimicrobial era, acute pyogenic meningitis was almost always fatal and neurological sequelae were common in most survivors.7,18 Despite major advances in antimicrobial chemotherapy, rapid diagnostic techniques, and the development of effective pneumococcal and meningococcal vaccines, the annual incidence and mortality rates for bacterial meningitis have remained essentially unchanged over the past decade. In 1978, more than 4000 cases of acute bacterial meningitis were reported to the Centers for Disease Control, representing a rate of 0.19 cases/ 100,000 population with an overall case-fatality rate of 13.6%.23
Keywords
- Bacterial Meningitis
- Alternative Complement Pathway
- Acute Bacterial Meningitis
- Meningococcal Vaccine
- Human Cerebrospinal Fluid
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Tofte, R.W. (1983). Pathogenesis of Bacterial Meningitis. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_21
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