Abstract
In central grey matter, activity-related release of K+ from neurons can result in considerable K+ accumulation in the extracellular space. It is likely that synaptic currents contribute to these rises in extracellular K+ concentration ([K+]o). However, this contribution cannot be readily distinguished under conditions of neuronal excitation and associated high K+ conductance.Increases in [K+]o have been observed near medullary respiratory neurons during synaptic inhibition (Richter et al.,1978), and have also been noted following application of γ-aminobutyric acid (GABA) in cerebral cortex (Brinley et al., 1960) and spinal cord (Kudo and Fukuda, 1976). In the present investigation, we have studied the effects of two putative inhibitory neurotransmitters, serotonin (5HT) and GABA, on [K+]o in the rat hippocampal slice preparation.
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References
Azmita, E.C., and Segal, M., 1978, An autoradiographic analysis of the differential ascending projections of the dorsal and medisn raphe nuclei in the rat, J. Comp. Neuro., 179:641.
Alger, B.E., and Nicoll, R.H., 1971, GABA-mediated biphasic inhibitory responses in hippocampus, Natur., 281:315.
Brinley, F.J., Kandel, E.R., and Marshall, W.H., 1960, Effect of gamma-aminobutyric acid (GABA) on K42 outflow from rabbit cortex. J. Neuro Physiol., 23:237.
Deschenes, M., and Feltz, P., 1976, GABA-induced rise of extracellular potassium in dorsal root ganglia: an electrophysiological study in viv., Brain Res., 118:494.
Kudo, Y., and Fukuda, H., 1976, Alteration of extracellular K+ activity induced by amino-acids in the frog spinal cord, Jpn. J.Pharmaco., 26:385.
Lux, H.D., and Neher, E., 1973, The equilibration time course of [K+]o in cat cortex, Exp. Brain Res., 17:190.
Richter, D.W., Camerer, H., and Sonnhof, V., 1978, Changes in extracellular potassium during the spontaneous activity of medullary respiratory neurones, Pflügers Arch., 376:139.
Schwartzkroin, P.A., 1975, Characteristics of CA1 neurons recorded intracellularly in the hippocampal slice, Brain Res., 85:423.
Segal, M., in press, Effects of 5HT on neurons in the hippocampal slice, J. Physiol.
Segal, M., and Gutnick, M.J., in press, Effects of serotonin on extracellular potassium concentration in the rat hippocampal slice, Brain Re.
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© 1981 Plenum Press, New York
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Gutnick, M.J., Segal, M. (1981). Serotonin and GABA-Induced Fluctuations in Extracellular Ion Concentration in the Hippocampal Slice. In: Syková, E., Hník, P., Vyklický, L. (eds) Ion-Selective Microelectrodes and Their Use in Excitable Tissues. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9224-2_28
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DOI: https://doi.org/10.1007/978-1-4615-9224-2_28
Publisher Name: Springer, Boston, MA
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