Abstract
Although lithium salts (Li) are widely used in the treatment of mania and recurrent depression, their mechanism of action is still unclear (Schou, 197 6). Since it seems possible that Li exerts direct or indirect actions on other ions, we investigated Li-effects upon extracellular potassium by means of ion selective microelectrodes (ISME) responding to Li+ and K+, respectively (Ullrich et al., 1980). The parallel fibre-Purkinje cell pathway of the cerebellar cortex was used as a convenient model of unmyelinated fibres with numerous synapses.
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© 1981 Plenum Press, New York
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ten Bruggencate, G., Ullrich, A., Baierl, P. (1981). Changes of Extracellular Potassium in Rat Cerebellar Cortex Indicate a Reduced Na-K-Pump Activity during Acute and Chronic Li-Application. In: Syková, E., HnÃk, P., Vyklický, L. (eds) Ion-Selective Microelectrodes and Their Use in Excitable Tissues. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9224-2_24
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DOI: https://doi.org/10.1007/978-1-4615-9224-2_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9226-6
Online ISBN: 978-1-4615-9224-2
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