Skip to main content
SpringerLink
Log in

Photodynamic Therapy of Infections

  • Chapter
Trends in Photobiology

Abstract

Photodynamic action involves the photo-oxidation of biological molecules in the presence of a sensitizer dye and oxygen (1). The phenomenon was first observed by Marcacci (2), but it is usual to credit the discovery to Raab (3) who in 1900 described the inactivation of Paramecia cultures with visible light in the presence of acridine orange. The same year Tappeiner (4) observed that the photodynamically active dyes were fluorescent. Two years later Ledoux-Lebard (5) reported that molecular oxygen was required for the reaction. Work during the next four decades mainly involved the determination of the nature of the substrates which could be damaged by photodynamic action and the chemical nature of the dyes. Along these lines Tappeiner (6) described the inactivation of the proteins diastase, invertase, papain and trypsin by the photodynamic action of eosin and noted that this was due to the destruction of aminoacids.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blum, H. F. (1941) in Photodynamic action and diseases caused by light, Heinhold, New York.

    Google Scholar 

  2. Marcacci, A. (1888) Arch. Ital. Biol. 9:2

    Google Scholar 

  3. Raab, V.O. (1900) Z. Biology 39:524

    Google Scholar 

  4. Tappeiner, H. (1900) Munch. Med. Wschr. 47:5

    Google Scholar 

  5. Ledoux-Lebard (1902) Ann. Inst. Pasteur, 16:587

    Google Scholar 

  6. Tappeiner, H. (1903) Ber. Deut. Chem. Ges. 36:3035

    Article  Google Scholar 

  7. Harris, D. T. (1926) Biochem. J. 20:288

    Google Scholar 

  8. Carter, C.W. (1928) Biochem. J. 22:575

    Google Scholar 

  9. Spikes, J.D. and Straight, R. (1967) Ann. Rev. Phys. Chem. J 8:409

    Article  Google Scholar 

  10. Moore, C., Wallis, C., Melnick, J. L. and Kuns, M. D. (1972) Infect. Immunol, 5:169

    Google Scholar 

  11. Wallis, C. and Melnick, J. L. (1973) Program and Abstracts, First Annual Meeting of the American Society for Photobiolo-gy. 133.

    Google Scholar 

  12. Friedrich, E.G., Jr. (1973) Obstet, and Gynecol. 41:74

    Google Scholar 

  13. Jarrat, M. and Knox, J. M. (1974) Prog, in Dermatol. 8:1

    Google Scholar 

  14. Melnick, J. and Wallis, C. (1977) Annals New York Acad. Sci. 284:171

    Article  Google Scholar 

  15. Felber, T.D., Smith, E. B., Knox, J. M., Wallis, C. and Melnick, J. L. (1973) J. Am. Med. Assoc. 223:289

    Article  Google Scholar 

  16. Kaufman, R.H., Gardner, H. L., Brown, D., Wallis, C., Rawls, W.E. and Melnick, J. L. (1973) Am. J. Obstet. Gynecol. 117:1144

    Google Scholar 

  17. Roome, A. P., Tinkler, A. E., Hilton, A. L., Montefiore, D.G. and Walter, D. (1975) Br. J. Vener. Dis. 51:130

    Google Scholar 

  18. Taylor, P. K. and Doherty, N. R. (1975) Br. J. Vener. Dis. 5_l_:l25

    Google Scholar 

  19. Myers, M. G., Oxman, M. N., Clark, J.E. and Arndt, K.A.(1975) N. England J. Med. 293:946

    Article  Google Scholar 

  20. Myers, M. G., Oxman, M. N., Clark, J.E. and Arndt, K.A.(1976) J. Infect. Dis. 133 : (Suppl. A) 145

    Article  Google Scholar 

  21. Santamaria, L. and Prino, G. (1972) in Res. Prog. Org.Biol. Med. Chem. edited by U. Gallo and L. Santamaria,Vol. Ill, Parti, p. 13, North-Holland Publ. Co. Amsterdam

    Google Scholar 

  22. Bourdon, J. and Schnuriger, B. (1967) in Physics and Chemis try of the Organic Solid State edited by D. Fox, M. Labes and A. Weissberger, Vol. III, p. 139, Interscience, New York

    Google Scholar 

  23. Yamamoto, N. (1972) in Res. Prog. Org. Biol. Med. Chem. edited by U. Gallo and L. Santamaria, Vol. Ill, part 1, p;297, North-Holland Pub. Co. Amsterdam

    Google Scholar 

  24. Ito, T. (1978) Photochem. Photobiol. 28:493

    Article  Google Scholar 

  25. Vodrazka, Z. (1959) Chem. Lysty 53:829

    Google Scholar 

  26. Weil, L. (1965) Arch. Biochem. Biophys. 110:57

    Article  Google Scholar 

  27. Spikes, J.D. and Livingston, R. (1969) Advanc. Rad. Biol. Vol. 3, p. 29, Edited by L. G. Augenstein, R. Mason and M. Zelle, Academic Press, New York

    Google Scholar 

  28. Spikes, J.D. and M. L. Macknight (1972) in Res. Prog. Org. Biol. Med. Chem. edited by U. Gallo and L. Santamaria, Vol. III, part 1, p. 124, North-Holland Publ. Co.Amsterdam

    Google Scholar 

  29. Ghiron, C.A. and Spikes, J.D. (1965) Photochem. Photobiol.4:13

    Article  Google Scholar 

  30. Spikes, J.D. and Straight, R. (1967) Ann. Rev. Phys. Chem. j_8:409

    Article  Google Scholar 

  31. Kumar, J. and Natarajan, A. T. (1965) Mut. Res. 2:11

    Article  Google Scholar 

  32. Naekai, S. and Saeki, T. (1964) Genet. Res. _3:I58

    Article  Google Scholar 

  33. Yamamoto, N. (1956) Virus 6:522

    Google Scholar 

  34. Yamamoto, N. (1958) J. Bacteriol. 75:443

    Google Scholar 

  35. Welsh, N. J. and Adams, M. H. (1954) J. Bacteriol. 68:122

    Google Scholar 

  36. Simon, M.I. and Van Vunakis, H. (1962) J. Mol. Biol. 4:488

    Article  Google Scholar 

  37. Wacker, A., Dellweg, H., Trager, L., Kornhauser, A., Lodeman, E., Turck, G., Selzer, H., Chandra, P. and Ishimoto, H. (1964) Photochem. Photobiol. 3:3 69

    Article  Google Scholar 

  38. Sussenbach, J. S. and Berends, W. (1965) Biochim. Biophys. Acta 103:360

    Google Scholar 

  39. Knowles, A. (1972) in Res. Prog. Org. Biol. Med. Chem. edited by U. Gallo and L. Santamaria, Vol. III, part 1, p. 183, North-Holland Publ. Co. Amsterdam

    Google Scholar 

  40. Mathews, M. M. (1963) J. Bacteriol. 85:322

    Google Scholar 

  41. Tereza, G. W., Tereza, N. L. and Millius, P. (1955) Can. J. Microbiol. 11:1028

    Article  Google Scholar 

  42. Garvin, R.T., Julian, G.R. and Rogers, S. J. (1969) Science 164:583

    Article  Google Scholar 

  43. Duijn, C. (1962) Exp. Cell. Res. 2_6:373

    Article  Google Scholar 

  44. Hill, R.B. (1960) Exp. Cell. Res. 21:106

    Article  Google Scholar 

  45. Klein, S. W. and Goodgol, S. H. (1959) Science 130:629

    Article  Google Scholar 

  46. Mathews, M. M. (1964) Nature 176:1212

    Google Scholar 

  47. Burnett, J. W. and Pathak, M. A. (1964) Arch. Dermatol.89:257

    Article  Google Scholar 

  48. Kautsky, H. and De Bruijn, H. (1931) Naturwissenschaften 29:1043

    Article  Google Scholar 

  49. Kautsky, H. (1939) Trans. Faraday Soc. 35:216

    Article  Google Scholar 

  50. Debey, P. and Douzou, P. (1970) Israel Journal Chem. 8:115

    Google Scholar 

  51. Churakova, N. I., Kravchenko, N.A., Serebryakov, E. B., Lavrov, I. A. and Kaversneva, E. D. (1973) Photochem. Pho tobiol. 18:201

    Article  Google Scholar 

  52. Kornhauser, A., Krinsky, N. I., Huang, P. K.C. and Glagett D.C. (1973) Photochem. Photobiol. 18:63

    Article  Google Scholar 

  53. Nilson, R. and Kearns, D. R. (1973) Photochem. Photobiol. 17:165

    Article  Google Scholar 

  54. Gollnick, K. (1968) Adv. Photochem. 6:1

    Article  Google Scholar 

  55. Foote, C.S. (1968) Science 162:963

    Article  Google Scholar 

  56. Rosenthal, I. and Pitts, Jr., J. N. (1971) Biophys. J. 11:963

    Article  Google Scholar 

  57. Pullman, B. and Pullman, A. (1963) in Quantum Biochemistry, Interscience Publishers Ltd., London

    Google Scholar 

  58. Bohme, H. and Gessler, E. (1968) Mol. Gen. Genet. 103:228

    Article  Google Scholar 

  59. Harm, W. (1968) Biochem. Biophys. Res. Comm. 32:350

    Article  Google Scholar 

  60. Jaffe-Brachet, A., Henry, N. and Errera, M. (1970) Mut. Res. J_2:9

    Google Scholar 

  61. Janovska, E., Zhestjanikov, V. and Vizdalova, M. (1970) Int. J. Rad. Biol. 21:317

    Article  Google Scholar 

  62. Menezes, S. (1975) PhD Thesis, Institute of Biophysics, Federal University of Rio de Janeiro, Brazil

    Google Scholar 

  63. Hollaender, A., Stapleton, G.E. and Martin, F. L. (1951) Nature 167:103

    Article  Google Scholar 

  64. Stapleton, G. E. and Engle, M.S. (I960) J. Bacteriol 80:544

    Google Scholar 

  65. Friesen, B. S., Iyer, P.S., Baptist, J. E., Meyn, R. and Rodgers, J. M. (1970) Int. J. Rad. Biol. L8:159

    Article  Google Scholar 

  66. Town, C. D., Smith, K. C. and Kaplan, H.S. (1971) J. Bac teriol. 105:127

    Google Scholar 

  67. Makman, R.S. and Sutherland, E.W. (1965) J. Biol. Chem. 240:209

    Google Scholar 

  68. Schwartz, D. and Beckwith, J. (1970) in The Lactose Operon, edited by D. Zipser and J. Beckwith, p. 417, Cold Spring Harbor Laboratory on Quant. Biol.

    Google Scholar 

  69. Zubay, G., Schwartz, D. and Beckwith, J. (1970) Proc. Natl. Acad. Sci. USA, 66:104

    Article  Google Scholar 

  70. Coelho, A. M. (1976) Master of Sciences Thesis, Institute of Biophysics, Federal University of Rio de Janeiro, Brazil

    Google Scholar 

  71. Freifelder, D. (1966) Virology 30:567

    Article  Google Scholar 

  72. Caldas, L. R., Menezes, S., Leitao, A. and Latarjet, R. (1974) C.R. Acad. Sc. Paris, 278D:2369

    Google Scholar 

  73. Bockstahler, L. E., Lytle, C. D. and Hellman, K. B. (1974) U.S. Depart, of Health, Educ. and Welfare, PHS, Food and Drug Adm. Bureau of Radiol. Health, DHEW Publication (FDA) 75–8013

    Google Scholar 

  74. Lytle, C. D., Bockstahler, L.E., Hellman, K. B., Goddard, J. G. and Brewer, P. P. (1978) in International Symposium on Current Topics in Radiobiology and Photobiology, p. 99, edited by R. M. Tyrrell, Academia Brasileira de Ciências, Rio de Janeiro, Brazil.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, R. J., 21941, Brazil

    L. R. Caldas, S. Menezes & R. M. Tyrrell

Authors
  1. L. R. Caldas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Menezes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. M. Tyrrell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratoire de Biophysique, INSERM U201, Muséum National d’Histoire Naturelle, Paris, France

    C. Hélène  & Th. Montenay-Garestier  & 

  2. Centre de Biophysique Moléculaire, CNRS, Orléans, France

    C. Hélène  & M. Charlier  & 

  3. Laboratoire de Physique, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France

    G. Laustriat

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Caldas, L.R., Menezes, S., Tyrrell, R.M. (1982). Photodynamic Therapy of Infections. In: Hélène, C., Charlier, M., Montenay-Garestier, T., Laustriat, G. (eds) Trends in Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9203-7_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9203-7_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9205-1

  • Online ISBN: 978-1-4615-9203-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation