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Advances in Phototherapy of Neonatal Hyperbilirubinemia

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Trends in Photobiology

Abstract

The advent of phototherapy for the treatment of jaundice in the newborn, originally reported in the studies of Cremer et al.1 in 1958, has stimulated further investigation of the transport, bind ing, and metabolism of bilirubin. It is not an exaggeration to say that this mode of therapy is considered by many to have been responsible for much of the recent broad medical interest in the photobiological effects of visible light. Because of this there has been a further interest in the study of varied light sources — fluorescent to laser.

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References

  1. Cremer, R. J., Perryman, P. W., and Richards, D. H. : Influence of light on the hyperbilirubinemia of infants, Lancet 1: 1994, 1958.

    Google Scholar 

  2. Boggs, T. R., Jr., Hardy, J. R., and Frazier, T. M.: Corre lation of neonatal serum total bilirubin concentrations, and developmental status at age 6 months, J. Pediat. 71:553, 1967.

    Article  Google Scholar 

  3. Gartner, L. M., Snyder, R. N., Chabron, R. S., and Bernstein, J.: Kernicterus: High incidence in premature infants with low serum bilirubin concentrations, Pediatrics 45:906, 1970.

    Google Scholar 

  4. Broderson, R.: Bilirubin: transport in the newborn infant, reviewed with relation to kernicterus, J. Pediat. 96:349, 1980.

    Article  Google Scholar 

  5. Levine, R. L.: Bilirubin: worked out years ago? Pediatrics, 64:380, 1979.

    Google Scholar 

  6. Mustafa, G., and King, T. E.: Binding of bilirubin with lipid. A possible mechanism of its toxic reaction in mitochondria,J. Biol. Chem. 245:1084, 1970.

    Google Scholar 

  7. Porter, E. G., and Waters, W. J.: A rapid micromethod for measuring the reserve albumin binding capacity in serum from newborn infants with hyperbilirubinemia, J. Lab. Clin. Med. 67:660, 1966.

    Google Scholar 

  8. Odell, G. B., Storey, G. N. B., and Rosenberg, L. A.: Studies in kernicterus. III. The saturation of serum proteins with bilirubin during neonatal life and its relationship to brain damage at 5 years. J. Pediat. 76:12, 1970.

    Article  Google Scholar 

  9. Lamola, A. A., Eisinger, J., Blumberg, W. E., Patel, S. C., and Flores, J.: Fluorometric study of the partition of bili rubin among blood components: basis for rapid microassays of bilirubin and bilirubin binding capacity in whole blood, in Analyt. Blodiem. 100:25–42, 1979.

    Article  Google Scholar 

  10. Ostrow, J. D., Berry, C. S., Knodell, R. G., and Zarembo, J. E.: Effect of phototherapy on bilirubin in Man and Rat, in Bilirubin Metabolism in the Newborn (II). Birth Defects: Orig. Art. Ser. 12:81–92, 1976. Excerpta Medica, N. Y. ed. D. Bergsma and S. H. Blondheim.

    Google Scholar 

  11. Stoll, M. S., Zenone, E. A., and Ostrow, J. D.: Preparation and properties of bilirubin photoisomers. Biochem. J. 183: 139, 1979.

    Google Scholar 

  12. Lightner, D. A., Wooldridge, T. A., and McDonough, A. F.: Configurational isomerization of bilirubin and the mechanism of jaundice phototherapy. Biochem. Biophys. Res. Commun. 86:235, 1979.

    Article  Google Scholar 

  13. McDonough, A. F., Lightner, D. A., and Wooldridge, T. A.: Geometric Isomerization of bilirubin IX-a and its dimethyl ester., J. Chem. Soc. Chem. Commun. Jan. 1979, pp. 110–112.

    Google Scholar 

  14. Lightner, D. A., Wooldridge, T. A., and McDonough, A. F.: Photobilirubin: an early bilirubin photoproduct detected by absorbance difference spectroscopy., Proc. Nat’l Acad. Sci. USA 76:29, 1979.

    Article  Google Scholar 

  15. Cohen, A. N., and Ostrow, J. D.: New concepts in phototherapy: Photoisomerization of Bilirubin IXa and potential toxic effects of light. Pediatrics 65:740, 1980.

    Google Scholar 

  16. Jori, G., Rossi, E., and Rubaltelli, F. F.: Evidence for visible light-induced covalent binding between bilirubin and serum albumin “in vitro” and “in vivo.” Trans. Amer. Soc. Photobiol., 1979.

    Google Scholar 

  17. Sisson, T. R. C., Kendall, N., Shaw, E., and Kechavarz-Oliai, L.: Phototherapy of jaundice in the newborn. II. Effect of various light intensities. J. Pediat. 81:35, 1972.

    Article  Google Scholar 

  18. Maurer, H. M., Fratkin, M., McWilliams, N.: Effects of phototherapy on platelet counts in low birth weight infants and on platelet production and life span in rabbits., Pediatrics 57:506, 1976.

    Google Scholar 

  19. Blackburn, M. G., Orzalessi, M. M., and Pigram, P.: Effect of light on fetal red blood cells in vivo. J. Pediat. 80:640, 1972.

    Google Scholar 

  20. Sisson, T. R. C., Slavin, B., and Hamilton, P. B.: The effects of broad and narrow spectrum fluorescent light on blood constituents, in “Bilirubin Metabolism in the Newborn (II),”

    Google Scholar 

  21. D. Bergsma, S.H. Blondheim, eds., Excerpta Medica, N. Y. Birth Defects: Orig. Art. Ser. 12:122–133, 1976.

    Google Scholar 

  22. Speck, W. T., Rosencranz, H. S.: Intracellular DNA-modifying activity of phototherapy lights. Pediat. Res. 10:553, 1976.

    Article  Google Scholar 

  23. Gantt, R., Parshad, R., Weig, R. A. G.: Fluorescent lightinduced DNA cross-linkage and chromatid breaks in mouse cells in culture.

    Google Scholar 

  24. Bakken, A. F.: Intestinal lactase deficiency as a factor in the diarrhea of light-treated jaundiced infants., N. E. J. Med. 295:1483, 1976.

    Google Scholar 

  25. Sisson, T. R. C.: Advantages of lactose-free formula for jaundiced infants undergoing phototherapy. Ross Clin. Res. Conf.: LBW Infants Fed Isomil., 1979, p. 101.

    Google Scholar 

  26. Sisson, T. R. C., Katzman, G., Shahrivar, F., and Root, A. W. : Effect of uncycled light on plasma human growth hormone in neonates. Pediat. Res. 9:280, 1975.

    Google Scholar 

  27. Park, T. S., Padget, S., Fiorentino, T., Root, A. W., and Sisson, T. R. C.: Effect of phototherapy and nursery light on neonatal biorhythms. Pediat. Res. 10:429, 1976.

    Google Scholar 

  28. Sisson, T. R. C., Ruiz, M., Wu, T-K., and Afuape, O. S.: Sleep patterns of newborn infants under phototherapy. Pediat. Res. 11:411, 1977.

    Article  Google Scholar 

  29. Sisson, T. R. C., Granati, B., Sonawane, R., Fiorentino, T.: Effect of light on the perfused Gunn rat liver. Pediat. Res. 12:399, 1978.

    Article  Google Scholar 

  30. Sisson, T. R. C., Ruiz, M., Wu, K-T., and Afuape, O. S.: Comparison of “incandescent” and fluorescent light sources in phototherapy. Pediat. Res. 12:535, 1978.

    Article  Google Scholar 

  31. Rubaltelli, F. F., Piovesan, A. L., Granati, B., Neidhart, C., and Semenzato, G.: The effects of phototherapy on immunologic competence: studies “in vivo” and “in vitro,” Trans. Amer. Soc. Photobiol., 1978.

    Google Scholar 

  32. Granati, B., Colleselli, P., Felice, M., and Rubaltelli, F. F.: The effects of bilirubin, phototreated bilirubin and light on spontaneous motility and chemotaxis of leucocytes. Trans. Eur. Soc. Pediat. Res., 1980.

    Google Scholar 

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© 1982 Plenum Press, New York

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Sisson, T.R.C. (1982). Advances in Phototherapy of Neonatal Hyperbilirubinemia. In: Hélène, C., Charlier, M., Montenay-Garestier, T., Laustriat, G. (eds) Trends in Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9203-7_28

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  • DOI: https://doi.org/10.1007/978-1-4615-9203-7_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9205-1

  • Online ISBN: 978-1-4615-9203-7

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