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Photobiology of Furocoumarins

  • D. Averbeck

Abstract

The photobiology of fucoroumarins has been covered by a number of reviews (1–4). In recent years we observed a rapid evolution in the knowledge on naturally occurring or synthetic furocoumarins which in the presence of near ultraviolet light or UVA, i.e. radia tion in the range of 320 to 380 nm, exhibit photosensitizing properties in various biological systems (1–4). The reaction scheme for furocoumarins with nucleic acids, especially with DNA, is well established (1, 4, 5, 6). It involves the formation of complexes between furocoumarins and DNA in the dark, and in the presence of 365-nm radiation the induction of cyclobutane type of mono-additions of pyrimidine bases in DNA involving the 3,4 or the 4’,5’ double bond of the furocoumarin molecule. Some of the 4’,5’ cycloadditions may photoreact further forming interStrand DNA cross-links (1, 4–7).

Keywords

Nuclear Mutation Diploid Yeast Error Prone Repair Haploid Yeast Strain Photobiological Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. Averbeck
    • 1
  1. 1.Section de BiologieInstitut CurieParis Cedex 05France

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