Immunologic Aspects of UV Carcinogenesis

  • Margaret L. Kripke


I am most grateful to the Association Internationale de Photo biologie for permitting me to honor the memory of Dr. Edna Margaret Roe. Dr. Roe was interested in the broad application of radiation research to the solution of biological problems. In keeping with her interest, it seems quite appropriate to address one very specific aspect of this topic which concerns the use of UV radiation to investigate fundamental processes in carcinogenesis and immunology.


Skin Cancer Ultraviolet Radiation Suppressor Cell Immunologic Aspect Contact Hypersensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M. L. Kripke, Antigenicity of murine skin tumors induced by ultraviolet light, J. Natl. Cancer Inst. 53:1333 (1974).Google Scholar
  2. 2.
    M. L. Kripke, Latency, histology and antigenicity of tumors induced by ultraviolet light in three inbred mouse strains, Cancer Res. 37:1395 (1977).Google Scholar
  3. 3.
    M. L. Kripke and M. S. Fisher, Immunologic parameters of ultraviolet carcinogenesis, J. Natl. Cancer Inst. 57:211 (1976).Google Scholar
  4. 4.
    A. Graffi, K.-H. Horn and G. Pasternak, Antigenic properties of tumors induced by different chemical and physical agents, in: “Specific Tumor Antigens,” R.J.C. Harris, ed., pp. 204–209, Munksgaard, Copenhagen (1967).Google Scholar
  5. 5.
    R. L. Daynes, C. W. Spellman, J. G. Woodward, and D. A. Stewart, Studies into the transplantation biology of ultraviolet light-induced tumors, Transplantation 23:343 (1977).CrossRefGoogle Scholar
  6. 6.
    E. C. De Fabo, and M. L. Kripke, Dose-response character istics of immunologic unresponsiveness to UV-induced tumors produced by UV irradiation of mice, Photochem. Photobiol. 30:385 (1979).CrossRefGoogle Scholar
  7. 7.
    E. C. De Fabo, and M. L. Kripke, Wavelength dependence and dose-rate independence of UV radiation-induced immunologic unresponsiveness of mice to a UV-induced fibrosarcoma, Photochem. Photobiol. 32:183 (1980).CrossRefGoogle Scholar
  8. 8.
    M. S. Fisher, and M. L. Kripke, Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis, Proc. Natl. Acad. Sci. USA74:1688 (1977).CrossRefGoogle Scholar
  9. 9.
    M. S. Fisher, and M. L. Kripke, Further studies on the tumor specific suppressor cells induced by ultraviolet radiation, J. Immunol. 121:1139 (1978).Google Scholar
  10. 10.
    C. W. Spellman, and R. A. Daynes, Modification of immunologic potential by ultraviolet radiation. II. Generation of suppressor cells in short-term UV-irradiated mice, Trans plantation 24:120 (1977).Google Scholar
  11. 11.
    R. T. Thorn, Specific inhibition of cytotoxic memory cells produced against UV-induced tumors in UV-irradiated mice, J. Immunol. 121:1920 (1978).Google Scholar
  12. 12.
    M. L. Kripke, J. S. Lofgreen, J. Beard, J. M. Jessup, and M. S. Fisher, In vivo immune responses of mice during carcinogenesis by ultraviolet radiation, J. Natl. Cancer Inst.59:1227 (1977).Google Scholar
  13. 13.
    K. C. Norbury, M. L. Kripke, and M. B. Budmen, In vitro reactivity of macrophages and lymphocytes from UV-irradiated mice, J. Natl. Cancer Inst. 59:1231 (1977).Google Scholar
  14. 14.
    C. W. Spellman, J. G. Woodward, and R. A. Daynes, Modification of immunologic potential by ultraviolet radiation. I. Immune status of short-term UV-irradiated mice, Transplan tation 24:112 (1977).CrossRefGoogle Scholar
  15. 15.
    M. L. Kripke, R. M. Thorn, P. H. Lill, C. I. Civin, and N. H. Pazmino, Further characterization of immunologic unresponsiveness induced in mice by UV radiation: Growth and induction of non-UV-induced tumors in UV-irradiated mice, Transplantation 28:212 (1979).CrossRefGoogle Scholar
  16. 16.
    J. M. Jessup, N. Hanna, E. Palaszynski, and M. L. Kripke, Mechanisms of depressed reactivity to dinitrochlorobenzene and ultraviolet-induced tumors during ultraviolet carcinogenesis in BALB/c mice, Cell. Immunol. 38:105 (1978).CrossRefGoogle Scholar
  17. 17.
    M. I. Greene, M. S. Sy, M. L. Kripke, and B. Benacerraf, Impairment of antigen-presenting cell function by ultraviolet radiation, Proc. Natl. Acad. Sci. USA 76:6591 (1979).CrossRefGoogle Scholar
  18. 18.
    N. L. Letvin, M. I. Greene, B. Benacerraf, and R. N. Germain, Immunologie effects of whole body ultraviolet (UV) irradia tion: Selective defect in splenic adherent cell function in vitro, Proc. Natl. Acad. Sci. USA 77:2881 (1980).CrossRefGoogle Scholar
  19. 19.
    F. C. Koranda, E. C. Dehmel, G. Kahn, and I. Penn, Cutaneous complications in immunosuppressed renal homograft recipients, J. Am. Med. Assoc. 229:419 (1974).CrossRefGoogle Scholar
  20. 20.
    V. Marshall, Premalignant and malignant skin tumours in immunosuppressed patients, Transplantation 17:272 (1974).CrossRefGoogle Scholar
  21. 21.
    E. O. Hoxtell, J. S. Mandel, S. S. Murray, L. M. Schuman, and R. W. Goltz, Incidence of skin carcinoma after renal transplantation, Arch. Dermatol. 113:436 (1977).CrossRefGoogle Scholar
  22. 22.
    A. L. Dellon, C. Potvin, P. R. Chretien, and C. N. Rogentine, The immunobiology of skin cancer, Plast. Reconstr. Surg.55:341 (1975).CrossRefGoogle Scholar
  23. 23.
    J. Viac, R. Bustamante, and J. Thivolet, Characterization of mononuclear cells in the inflammatory infiltrates of cutaneous tumors, Br. J. Dermatol. 97:1 (1977).CrossRefGoogle Scholar
  24. 24.
    S. Horowitz, D. Cripps, and R. Hong, Selective T cell killing of human lymphocytes by ultraviolet radiation, Cell. Immunol. 14:80 (1974).CrossRefGoogle Scholar
  25. 25.
    M. L. Kripke, Guest editorial: Speculations on the role of ultraviolet radiation in the development of malignant melanoma, J. Natl. Cancer Inst. 63:541 (1979).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Margaret L. Kripke
    • 1
  1. 1.Cancer Biology ProgramFrederick Cancer Research CenterFrederickUSA

Personalised recommendations