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Captopril

An Oral Angiotensin-Converting Enzyme Inhibitor Active in Man

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Captopril and Hypertension

Part of the book series: Topics in Cardiovascular Disease ((TCAD))

Abstract

Two types of inhibitors of the renin-angiotensin system have been available for clinical research.1,2 They both have the severe shortcoming that they must be administered parenterally, which makes chronic blockade of the system practically impossible. Furthermore, saralasin, a competitive inhibitor of the active hormone angiotensin II, has the disadvantage of inherent agonistic properties.3,4 On the other hand, because angiotensin-converting enzyme is identical with kininase II, its inhibitor teprotide (SQ 20,881) not only blocks angiotensin II generation but simultaneously may increase bradykinin,5 a potentially vasodilating hormone.

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Author information

Authors and Affiliations

  1. Department of Medicine, Université de Lausanne, Switzerland

    Hans R. Brunner M.D., B. Waeber M.D., G. A. Turini M.D. & J. P. Wauters M.D.

  2. Department of Medicine, Hôpital Cantonal Universitaire, CH-1011, Lausanne, Switzerland

    Hans R. Brunner M.D., B. Waeber M.D., G. A. Turini M.D. & J. P. Wauters M.D.

  3. Department of Medicine, Boston University School of Medicine, USA

    Haralambos Gavras M.D.

  4. Hypertension Section, Boston City Hospital, Boston, Massachusetts, 02118, USA

    Haralambos Gavras M.D.

Authors
  1. Hans R. Brunner M.D.
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  2. Haralambos Gavras M.D.
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  3. B. Waeber M.D.
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  4. G. A. Turini M.D.
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  5. J. P. Wauters M.D.
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Editor information

Editors and Affiliations

  1. New York Hospital/Cornell Medical Center, New York, New York, USA

    David B. Case  & John H. Laragh  & 

  2. Albert Einstein College of Medicine, The Bronx, New York, USA

    Edmund H. Sonnenblick

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© 1980 Plenum Publishing Corporation

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Brunner, H.R., Gavras, H., Waeber, B., Turini, G.A., Wauters, J.P. (1980). Captopril. In: Case, D.B., Sonnenblick, E.H., Laragh, J.H. (eds) Captopril and Hypertension. Topics in Cardiovascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9179-5_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9179-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9181-8

  • Online ISBN: 978-1-4615-9179-5

  • eBook Packages: Springer Book Archive

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