Abstract
Changes in myocardial performance are an important and clinically relevant consequence of phosphorous depletion (PD) both in man (1,2) and in experimental animals (3).0’Connor et al.(1) found in acutely phosphorous depleted alcoholic patients that stroke volume was low and reverted to normal upon administration of phosphate despite no change or even reduction of preload.Furthermore, Darsee and Nutter (2) described reversible congestive heart failure in chronically phosphorous depleted patients.These findings would indicate that PD interferes with the inotropic state of the myocardium.However, for obvious reasons, a number of parameters which might influence myocardial performance cannot be controlled in such severely ill patients.Fuller et al.(3) were able to reproduce experimentally reversible depression of myocardial performance in dogs with experimental PD.When inorganic serum phosphorous was lowered from 5,1 to 0,9 mg/dl with an associated 20% fall in muscular phosphorous concentration, stroke volume, peak blood flow and dP/dt were abnormally low and returned to normal upon administration of phosphate.
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References
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© 1980 Plenum Press, New York
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Hörl, W.H., Kreusser, W., Heidland, A., Ritz, E. (1980). Abnormalities of Glycogen Metabolism in Cardiomyopathy of Phosphorous Depletion. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_39
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DOI: https://doi.org/10.1007/978-1-4615-9167-2_39
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