Abstract
Several lines of evidence, which we have summarized recently elsewhere (1) have lent support to the hypothesis, stated previously by us (2) as well as others, that progression of chronic renal failure may be in part attributable to the vicious circle depicted in Figure 1. The most impressive evidence pertinent to this hypothesis consists of clinical studies in which phosphate intake was restricted early in the course of chronic renal failure in man, in order to prevent renal osteodystrophy (3, 4). An unexpected result of these studies was that progression of renal insufficiency was much slower than in comparable series of patients. In addition, phosphate restriction can prevent the progression to terminal uremia of certain types of experimentally induced renal failure in rats (5, 6).
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Walser, M. (1980). Calcium Carbonate-Induced Effects on Serum Ca X P Product and Serum Creatinine in Renal Failure: A Retrospective Study. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_33
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DOI: https://doi.org/10.1007/978-1-4615-9167-2_33
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