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Response of Red Cell Phosphate to Acute and Chronic Changes in Plasma Phosphate in Man

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Phosphate and Minerals in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 128))

Abstract

Inorganic phosphate (Pi) is known to participate in many biochemical reactions and is a regulator in several metabolic pathways (1). In the red blood cell the structural integrity of the membrane is dependent on metabolic energy derived from glycolysis to produce ATP (2). Pi plays a major role in the red blood cell in regulating the concentrations of ATP and 2,3-diphosphoglycerate (3). In spite of the increasing knowledge about phosphate depletion syndromes, there is still a debate about the mechanisms of phosphate transport across cell membranes and about factors which control its extracellular and intracellular concentrations.

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References

  1. E.A. Newsholme and C. Start. Regulation in Metabolism John Wiley London (1973).

    Google Scholar 

  2. H.S. Jacob and T. Amsden. Acute hemolytic anaemia and rigid red cells in hypophosphatemia. New England Journal of Medicine. 285: 1446–1450, (1971).

    Article  PubMed  CAS  Google Scholar 

  3. S.I. Travis, H.I. Sugarmann and R.L. Ruberg. Alterations of red cell glycolytic intermediates and oxygen transport as a consequence of hypophosphatemia in patients receiving intravenous hyperalimentation. New England Journal of Medicine. 283: 763–768, (1971).

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  4. R.J. Hall. An improved method for the micro determin ation of inorganic phosphate in small volumes of biological fluids. Journal of Medical Laboratory Technology. 20 No. 2. 97–103, (1963).

    PubMed  CAS  Google Scholar 

  5. R.J. Walton, R.G.G. Russell and R. Smith. Changes in the renal and extrarenal handling of phosphate induced by Disodium Etidronate (EHDP) in man. Clinical Science and Molecular Medicine. 49: 45–56, (1975).

    PubMed  CAS  Google Scholar 

  6. H.S. Tenenhouse and C,R. Scriver. Orthophosphatetransport in the erythrocyte of normal subjects and patients with X-linked hypophosphatemia. The Journal of Clinical Investigation. 55: 644–654, (1975).

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© 1980 Plenum Press, New York

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Preston, C.J., Challa, A., Phillips, J.E., Foden, S.E., Douglas, D.L., Russell, R.G.G. (1980). Response of Red Cell Phosphate to Acute and Chronic Changes in Plasma Phosphate in Man. In: Massry, S.G., Ritz, E., Jahn, H. (eds) Phosphate and Minerals in Health and Disease. Advances in Experimental Medicine and Biology, vol 128. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9167-2_29

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  • DOI: https://doi.org/10.1007/978-1-4615-9167-2_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9169-6

  • Online ISBN: 978-1-4615-9167-2

  • eBook Packages: Springer Book Archive

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