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Chemistry of Naturally Occurring Pyrimidine Nucleosides and Analogues

  • Chapter
Nucleoside Analogues

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 26))

Abstract

Pyrlmidine nucleosides (as phosphodiester units) are major components of nucleic acids of all types and a number of structurally modified pyrimidine nucleosides are known as minor components. Pyrimidine nucleosides per se have been isolated from marine sponges and from microbiological sources. Some of the latter compounds have rather complex structures and exhibit antibiotic properties. The chemistry of pyrimidine nucleosides began at an early point historically with the isolation of nucleic acids and efforts to elucidate the chemical structures of the monomeric components. The interesting chemistry, origin from natural sources, and observed biological response properties of various pyrimidine nucleosides, their derivatives, and analogues have stimulated wide ranging chemical and bio-medical research efforts in this area.

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Authors and Affiliations

  1. Department of Chemistry, The University of Alberta, Edmonton, Alberta, Canada, T6G 2G2

    Morris J. Robins

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  1. Morris J. Robins
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Editors and Affiliations

  1. The University of Birmingham, Birmingham, UK

    Richard T. Walker

  2. Katholieke Universiteit Leuven, Leuven, Belgium

    Erik De Clercq

  3. Max-Planck Institut für Experimentelle Medizin, Göttingen, West Germany

    Fritz Eckstein

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© 1979 Plenum Press, New York

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Robins, M.J. (1979). Chemistry of Naturally Occurring Pyrimidine Nucleosides and Analogues. In: Walker, R.T., De Clercq, E., Eckstein, F. (eds) Nucleoside Analogues. NATO Advanced Study Institutes Series, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9137-5_5

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  • DOI: https://doi.org/10.1007/978-1-4615-9137-5_5

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