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Development of Antiherpes Virus Agents on the Basis of Virus Induced Enzymes

  • Chapter
Nucleoside Analogues

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 26))

Abstract

Herpes Viruses induce many disease entities in humans. Unfortunately, the drugs currently used in the clinical treatment of herpes virus infectious diseases all have substantial toxicity (1,2,3). Recently, several nucleoside analogs such as AraA, 5-alkyl dUrd and Acycloguanine were shown to be effective against herpes simplex virus type 1 infectious diseases without having much toxicity in humans (4–10) however, they all have their own limitation of use. For example, 5-alkyl-dUrd and acycloguanosine will not be active against herpes virus which cannot induce thier virus specific thymidine kinase (TK) (6,11) or herpes virus which could induce a virus specific TK but cannot recognize either compound as its substrate. AraA toxicity will be affected by the amount of adenosine deaminase in human cells. Therefore, it is important to develop more specific antiherpes virus agents for the treatment of herpes virus induced diseases, particularly in patients undergoing cancer chemotherapy or with immune deficiencies.

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Author information

Authors and Affiliations

  1. The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27514, USA

    Y.-C. Cheng, M. Ostrander, D. Derse & J.-Y Chen

  2. Roswell Park Memorial Institute, Buffalo, New York, 14263, USA

    Y.-C. Cheng, M. Ostrander, D. Derse & J.-Y Chen

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  1. Y.-C. Cheng
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  2. M. Ostrander
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  3. D. Derse
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  4. J.-Y Chen
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Editor information

Editors and Affiliations

  1. The University of Birmingham, Birmingham, UK

    Richard T. Walker

  2. Katholieke Universiteit Leuven, Leuven, Belgium

    Erik De Clercq

  3. Max-Planck Institut für Experimentelle Medizin, Göttingen, West Germany

    Fritz Eckstein

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© 1979 Plenum Press, New York

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Cheng, YC., Ostrander, M., Derse, D., Chen, JY. (1979). Development of Antiherpes Virus Agents on the Basis of Virus Induced Enzymes. In: Walker, R.T., De Clercq, E., Eckstein, F. (eds) Nucleoside Analogues. NATO Advanced Study Institutes Series, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9137-5_10

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  • DOI: https://doi.org/10.1007/978-1-4615-9137-5_10

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