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Myeloperoxidase-Mediated Cytotoxic Systems

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Book cover Biochemistry and Metabolism

Abstract

Myeloperoxidase (MPO), H2O2, and a halide form a powerful antimicrobial system which is effective against a variety of microorganisms. This system is also toxic to certain mammalian cells, namely, spermatozoa, erythrocytes, leukocytes, platelets, and tumor cells. This review (see also Klebanoff, 1975a; Klebanoff and Clark, 1978) will consider the properties of the MPO-mediated antimicrobial system and its role in the intracellular and extracellular toxicity of the polymorphonuclear leukocyte (PMN).

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Abbreviations

cis-DBE:

cis-dibenzoylethylene

CGD:

chronic granulomatous disease

DABCo:

1,4-diazabicyclo[2.2.2]octane

D20:

deuterium oxide

DPF:

diphenylfuran

HO2 :

perhydroxy radical

LPO:

lactoperoxidase

MPO:

myeloperoxidase

O2· - :

superoxide anion

102 :

singlet oxygen

OH·:

hydroxyl radical

PMN:

polymorphonuclear leukocyte

SOD:

superoxide dismutase

T3 :

trriodothyronine

T4 :

thyroxine.

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  1. Department of Medicine, University of Washington, Seattle, Washington, 98195, USA

    Seymour J. Klebanoff

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  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA

    Robert R. Strauss

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Klebanoff, S.J. (1980). Myeloperoxidase-Mediated Cytotoxic Systems. In: Sbarra, A.J., Strauss, R.R. (eds) Biochemistry and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9134-4_11

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