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Separation of Germinal Centres from Chicken Spleen

  • A. M. Smithyman
  • K. Carr
  • D. Forman
  • R. G. White
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 114)

Abstract

The role of germinal centres in immune reactions has intrigued immunologists for almost a hundred years, since Flemming’s classical monograph of 1885 (1), and has been a central theme throughout this Conference series. Such interest derives from the implication of these structures in the following aspects of the immune response:
  1. 1.

    Expansion of population of immunocompetent cells (2,3)

     
  2. 2.

    Generation of B-memory cells (4)

     
  3. 3.

    Induction of immunological tolerance (5)

     
  4. 4.

    Long-term retention of antigen (6,7)

     
  5. 5.

    Multiple antigen retention (8)

     
  6. 6.

    Antibody production (7)

     
  7. 7.

    Feedback control of antibody production (9, 10)

     
  8. 8.

    Homing of Bursa-derived cells (11)

     
  9. 9.

    T-B cell interaction (12)

     
  10. 10.

    Antigen-B cell interaction (13)

     

Keywords

Germinal Centre Immunocompetent Cell Pulp Tissue Light Diaphragm Immunological Tolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Flemming, W. Archiv, f. Mikros. Anat. Entwicklung. 24 (1885) 50.CrossRefGoogle Scholar
  2. 2.
    White, R.G., In: Mechanisms of Antibody Formation. M. Holub, L. Jaraskova (Eds.).Prague. Czechoslovak Acad. p.25 (1960).Google Scholar
  3. 3.
    Good, R.A., Cain, W.A., Percy, D.Y., Dunt, P.B., Menwissen, H.J., Rodey, G.E., Cooper, M.D., In: Lymphatic Tissue and Germinal Centers in Immune Responses. L. Fiore-Donati and M.G, Hanna, Jr. (Eds,), Plenum Press, New York, p, 33 (1969).CrossRefGoogle Scholar
  4. 4.
    Thorbecke, G., Lerman, S.P., In: The Reticuloendothelial System in Health and Disease: Functions and Characteristics, S.M. Reichard, M.R., Escobar, H. Friedman (Eds.). Plenum Press, New York, p. 83 (1976).Google Scholar
  5. 5.
    Ada, G,L., Parish, CR., Proc, Nat. Acad. Sci. 61 (1968) 556.CrossRefGoogle Scholar
  6. 6.
    Ada, G.L., Williams, J.M., Immunology 10 (1966) 417.Google Scholar
  7. 7.
    White, R.G., French, V.I., Stark, J.M., J. Med. Microbiol. 3 (1) (1970) 65.PubMedCrossRefGoogle Scholar
  8. 8.
    Henderson, D.C, Smithyman, A.M., J. Immunol. Methods 6 (1974) 115.PubMedCrossRefGoogle Scholar
  9. 9.
    Sinclair, N.R.St.C., Chan, P.L., In: Morphological and Functional Aspects of Immunity, K. Lindahl-Kiessling, G, Aim, M,G, Hanna, Jr, (Eds.). Plenum Press, New York, p. 609 (1971).CrossRefGoogle Scholar
  10. 10.
    White, R.G., In: Immunopotentiation. Ciba Foundation Symp. 18. ASP, Amsterdam. p.47 (1973).CrossRefGoogle Scholar
  11. 11.
    Durkin, H.G., Theis, G.A., Thorbecke, G.J., See reference 9,p.119.Google Scholar
  12. 12.
    Gutman, G.A., Weissman, I.L., See reference 9, p.Google Scholar
  13. 13.
    Smithyman, A.M., J. Immunol. Methods. 12 (1977) 217.CrossRefGoogle Scholar
  14. 14.
    Smithyman, A.M., J. Dev. Comp. Immunology 1 (1977) 263.CrossRefGoogle Scholar
  15. 15.
    Fagreus, A., Acta Med. Scand. (suppl.) 204 (1930).Google Scholar
  16. 16.
    Thorbecke, G.J., Keuning, F.J., J. Infect. Dis. 98 (1956) 157.PubMedCrossRefGoogle Scholar
  17. 17.
    Humphrey, J.H., Adv. Exp. Med. Biol. 66 (1976) 711.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • A. M. Smithyman
    • 1
  • K. Carr
    • 2
  • D. Forman
  • R. G. White
    • 3
  1. 1.Sloan-Kettering InstituteNew YorkUSA
  2. 2.Department of AnatomyGlasgow UniversityGlasgowScotland
  3. 3.Department of Bacteriology and ImmunologyGlasgow UniversityGlasgowScotland

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