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Survival and Immunological Responsiveness of Rat-Mouse Bone Marrow Chimeras

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Function and Structure of the Immune System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 114))

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Abstract

Successful bone marrow transplantation (BMT) in an allogeneic donor-recipient combination can be achieved by eliminating all lymphocytes from donor BM. Our group has presented data showing that this, using a selectively lymphocytotoxic antiserum, leads to permanent hemopoietic chimerism without GVHR and to subsequent selective acceptance of skin grafts in a strongly and fully allogeneic rat strain combination (1,2). To determine whether the efficiency of this BM treatment is peculiar to the chosen model or whether its success is based on a more general principle, we tried to apply our protocol to a xenogeneic system with rats as donors and mice as recipients of BM.

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References

  1. Müller-Ruchholtz, W., Wottge, H.-U., Müller-Hermelink, H.K. Transplant. Proc. 7 (1975) 859.

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  2. Müller-Ruchholtz, W., Wottge, H.-U., Müller-Hermelink, H.K. Transplant. Proc. 8 (1976) 537.

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  3. Müller-Ruchholtz, W., Wottge, H.-U., Müller-Hermelink, H.K. In: Advances in experimental medicine and biology, Vol. 66 Immune reactivity of lymphocytes p. 147 (1976).

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Author information

Authors and Affiliations

  1. Dept. of Immunology/Institute of Hygiene, University of Kiel, Kiel, W. Germany

    H.-U. Wottge & W. Müller-Ruchholtz

  2. Dept. of Pathology, University of Kiel, Kiel, W. Germany

    H. K. Müller-Hermelink

Authors
  1. H.-U. Wottge
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  2. H. K. Müller-Hermelink
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  3. W. Müller-Ruchholtz
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Editor information

Editors and Affiliations

  1. University of Kiel, Kiel, Germany

    Wolfgang Müller-Ruchholtz  & Hans Konrad Müller-Hermelink  & 

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© 1979 Plenum Press, New York

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Wottge, HU., Müller-Hermelink, H.K., Müller-Ruchholtz, W. (1979). Survival and Immunological Responsiveness of Rat-Mouse Bone Marrow Chimeras. In: Müller-Ruchholtz, W., Müller-Hermelink, H.K. (eds) Function and Structure of the Immune System. Advances in Experimental Medicine and Biology, vol 114. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9101-6_43

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  • DOI: https://doi.org/10.1007/978-1-4615-9101-6_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9103-0

  • Online ISBN: 978-1-4615-9101-6

  • eBook Packages: Springer Book Archive

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